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Open AccessArticle

Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten

by Zhijuan Ding 1,2, Yanxia Liu 1,2, Jingya Ruan 1,2, Shengcai Yang 1,2, Haiyang Yu 1,2, Meiling Chen 1,2, Yi Zhang 1,2,* and Tao Wang 1,2,*
1
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
2
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
Molecules 2017, 22(8), 1309; https://doi.org/10.3390/molecules22081309
Received: 6 July 2017 / Revised: 1 August 2017 / Accepted: 4 August 2017 / Published: 6 August 2017
As a Mongolian native medicine and Ewenki folk medicinal plant, Gentianella acuta has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of G. acuta whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (1), B (2), gentilignanoside A (3), (1R)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl-O-β-d-glucopyranoside (4), and (3Z)-3-hexene-1,5-diol 1-O-α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside (5) were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (710, 1316, 18, 19, 21, 22, and 25) previously obtained in the plant were analyzed. As results, new compound 5, some secoiridoid-type monoterpenes 7, 10, 1214, 16, and 17, as well as 7-O-9′-type lignans 31 and 32 displayed significant inhibitory effect on contraction tension at 40 μM. View Full-Text
Keywords: Gentianella acuta (Michx.) Hulten; lignan; iridoid- and secoiridoid-type monoterpene; intestine motility; mouse isolated intestine tissue Gentianella acuta (Michx.) Hulten; lignan; iridoid- and secoiridoid-type monoterpene; intestine motility; mouse isolated intestine tissue
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Ding, Z.; Liu, Y.; Ruan, J.; Yang, S.; Yu, H.; Chen, M.; Zhang, Y.; Wang, T. Bioactive Constituents from the Whole Plants of Gentianella acuta (Michx.) Hulten. Molecules 2017, 22, 1309.

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