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Molecules 2017, 22(6), 895;

Recent Advances in Asymmetric Organocatalyzed Conjugate Additions to Nitroalkenes

Department of Organic Chemistry and Institute of Organic Synthesis (ISO), Faculty of Sciences, University of Alicante, PO Box 99, 03080 Alicante, Spain
Authors to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 26 May 2017 / Accepted: 26 May 2017 / Published: 29 May 2017
(This article belongs to the Special Issue Asymmetric Synthesis 2017)


The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks. Thanks to the rapid development of asymmetric organocatalysis, significant progress has been made during the last years in achieving efficiently this process, concerning chiral organocatalysts, substrates and reaction conditions. This review surveys the advances in asymmetric organocatalytic conjugate addition reactions to α,β-unsaturated nitroalkenes developed between 2013 and early 2017. View Full-Text
Keywords: nitroalkenes; Michael addition; organocatalysis; asymmetric synthesis nitroalkenes; Michael addition; organocatalysis; asymmetric synthesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Alonso, D.A.; Baeza, A.; Chinchilla, R.; Gómez, C.; Guillena, G.; Pastor, I.M.; Ramón, D.J. Recent Advances in Asymmetric Organocatalyzed Conjugate Additions to Nitroalkenes. Molecules 2017, 22, 895.

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