Next Article in Journal
Chemical Constituents of Supercritical Extracts from Alpinia officinarum and the Feeding Deterrent Activity against Tribolium castaneum
Previous Article in Journal
Anti-Proliferative Effect of Triterpenoidal Glycosides from the Roots of Anemone vitifolia through a Pro-Apoptotic Way
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(4), 646;

Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica

School of Pharmacy, Qingdao University, Qingdao 266021, Shandong, China
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 16 March 2017 / Revised: 13 April 2017 / Accepted: 15 April 2017 / Published: 17 April 2017
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1220 KB, uploaded 17 April 2017]   |  


Phytochemical investigation of the shells of Metaplexis japonica (Thunb.) Makino, belonging to the family of Apocynaceae, afforded three new pregnane steroids, metajapogenins A–C, along with three known compounds. The structures of the new compounds were elucidated as 12β,14β,17β-trihydroxypregna-3,5-dien-7,20-dione, 12β,14β,17β,20β-tetrahydroxypregna-3,5-dien-7-one; 3β,12β,14β,17β-tetrahydroxypregn-5-ene-7,20-dione on the basis of extensive spectroscopic evidence derived from 1D; 2D-NMR experiments and mass spectrometry. The known compounds included pergularin; 12-O-acetylpergularin; and pergularin-3-O-β-d-oleandropyranose; which were identified for the first time in the shells of M. japonica. View Full-Text
Keywords: Metaplexis japonica (Thunb.) Makino; Apocynaceae; pregnane steroid; metajapogenins A–C Metaplexis japonica (Thunb.) Makino; Apocynaceae; pregnane steroid; metajapogenins A–C

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Yao, H.-L.; Liu, Y.; Liu, X.-H.; Gao, H.; Liu, K.; Shao, Y.-L.; Fang, X.-Y.; Wang, W. Metajapogenins A–C, Pregnane Steroids from Shells of Metaplexis japonica. Molecules 2017, 22, 646.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top