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Molecules 2017, 22(4), 529;

New Acorane-Type Sesquiterpene from Acorus calamus L.

Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China
National Center for Natural Products Research, University of Mississippi, University MS 38677, USA
Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 March 2017 / Revised: 21 March 2017 / Accepted: 22 March 2017 / Published: 26 March 2017
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [2404 KB, uploaded 26 March 2017]   |  


A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line. View Full-Text
Keywords: Acorus calamus L.; Araceae; acorane-type sesquiterpene; biosynthetic pathway; cell proliferation Acorus calamus L.; Araceae; acorane-type sesquiterpene; biosynthetic pathway; cell proliferation

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Li, J.; Zhao, J.; Wang, W.; Li, L.; Zhang, L.; Zhao, X.-F.; Liu, Q.-R.; Liu, F.; Yang, M.; Khan, I.A.; Li, S.-X. New Acorane-Type Sesquiterpene from Acorus calamus L.. Molecules 2017, 22, 529.

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