Next Article in Journal / Special Issue
Novel 2,3-Dihydro-1H-pyrrolo[3,2,1-ij]quinazolin-1-ones: Synthesis and Biological Evaluation
Previous Article in Journal
Purification and Characterization of Antioxidant Peptides of Pseudosciaena crocea Protein Hydrolysates
Previous Article in Special Issue
A Metal-Free Regioselective Multicomponent Approach for the Synthesis of Free Radical Scavenging Pyrimido-Fused Indazoles and Their Fluorescence Studies
Article

Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation

Department of Biology and Environment, Zhejiang A&F University, Shaoxing 311800, Zhejiang, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2017, 22(1), 53; https://doi.org/10.3390/molecules22010053
Received: 21 November 2016 / Revised: 22 December 2016 / Accepted: 28 December 2016 / Published: 30 December 2016
(This article belongs to the Collection Heterocyclic Compounds)
A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible CuI/CuIII mechanism of C-N coupling/C-H carbonylation transformation was proposed. View Full-Text
Keywords: benzo-1,4-oxazepine; copper catalyst; tandem transformation; C-N coupling; C-H carbonylation benzo-1,4-oxazepine; copper catalyst; tandem transformation; C-N coupling; C-H carbonylation
Show Figures

Scheme 1

MDPI and ACS Style

Zhao, X.; Zhang, J.; Zheng, Z.; Xu, R. Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation. Molecules 2017, 22, 53. https://doi.org/10.3390/molecules22010053

AMA Style

Zhao X, Zhang J, Zheng Z, Xu R. Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation. Molecules. 2017; 22(1):53. https://doi.org/10.3390/molecules22010053

Chicago/Turabian Style

Zhao, Xiaojia, Jiong Zhang, Zeqin Zheng, and Runsheng Xu. 2017. "Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation" Molecules 22, no. 1: 53. https://doi.org/10.3390/molecules22010053

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop