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Molecules 2016, 21(8), 1089;

Five New Biphenanthrenes from Cremastra appendiculata

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
Medical College, Yangzhou University, Yangzhou 225009, China
Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Author to whom correspondence should be addressed.
Academic Editor: Dong-Kug Choi
Received: 3 July 2016 / Revised: 12 August 2016 / Accepted: 15 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Natural Products and Chronic Diseases)
PDF [565 KB, uploaded 19 August 2016]


Five new biphenanthrenes, cremaphenanthrenes A–E (15), along with six known ones, were isolated from the ethanolic extract of the tubers of Cremastra appendiculata (D. Don) Makino (Orchidaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. All the compounds obtained were tested in vitro for cytotoxic activities against colon (HCT-116), cervix (Hela), and breast (MDA-MB-231) cancer cell lines. They all showed moderate or weak cytotoxicities to the above cancer cell lines. View Full-Text
Keywords: Cremastra appendiculata; biphenanthrene; cytotoxic activity Cremastra appendiculata; biphenanthrene; cytotoxic activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liu, L.; Li, J.; Zeng, K.-W.; Jiang, Y.; Tu, P.-F. Five New Biphenanthrenes from Cremastra appendiculata. Molecules 2016, 21, 1089.

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