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Molecules 2016, 21(6), 734;

New 30-Noroleanane Triterpenoid Saponins from Holboellia coriacea Diels

Hunan Provincial Engineering & Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China
Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 May 2016 / Revised: 31 May 2016 / Accepted: 2 June 2016 / Published: 4 June 2016
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [455 KB, uploaded 4 June 2016]   |  


Three new 30-noroleanane triterpenoid saponins, akebonoic acid 28-O-β-d-glucopyranosyl-(1′′→6′)-β-d-glucopyranosyl ester (1), akebonoic acid 28-O-(6′′-O-caffeoyl)-β-d-glucopyranosyl-(1′′→6′)-β-d-glucopyranosyl ester (Holboelliside A, 2) and 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 3-O-(6′-O-caffeoyl)-β-d-glucopyranoside (Holboelliside B, 3) were isolated from the stems of Holboellia coriacea Diels, together with five known compounds, eupteleasaponin VIII (4), 3α-akebonoic acid (5), quinatic acid (6), 3β-hydroxy-30-norhederagenin (7) and quinatoside A (8). The structures of these compounds were determined on the basis of spectral and chemical evidence. Compounds 15 were evaluated for their inhibitory activity against three human tumors HepG2, HCT116 and SGC-7901 cell lines in vitro. View Full-Text
Keywords: Holboellia coriacea; nortriterpenoids; saponins; cytotoxicity Holboellia coriacea; nortriterpenoids; saponins; cytotoxicity

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Ding, W.; Li, Y.; Li, G.; He, H.; Li, Z.; Li, Y. New 30-Noroleanane Triterpenoid Saponins from Holboellia coriacea Diels. Molecules 2016, 21, 734.

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