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Molecules 2016, 21(6), 706;

An Approach to Characterizing the Complicated Sequential Metabolism of Salidroside in Rats

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 April 2016 / Revised: 25 May 2016 / Accepted: 25 May 2016 / Published: 30 May 2016
(This article belongs to the Section Natural Products Chemistry)
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Metabolic study of bioactive compounds that undergo a dynamic and sequential process of metabolism is still a great challenge. Salidroside, one of the most active ingredients of Rhodiola crenulata, can be metabolized in different sites before being absorbed into the systemic blood stream. This study proposed an approach for describing the sequential biotransformation process of salidroside based on comparative analysis. In vitro incubation, in situ closed-loop and in vivo blood sampling were used to determine the relative contribution of each site to the total metabolism of salidroside. The results showed that salidroside was stable in digestive juice, and it was metabolized primarily by the liver and the intestinal flora and to a lesser extent by the gut wall. The sequential metabolism method described in this study could be a general approach to characterizing the metabolic routes in the digestive system for natural products. View Full-Text
Keywords: salidroside; sequential metabolism; in situ closed-loop salidroside; sequential metabolism; in situ closed-loop

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Luo, Z.; Ma, X.; Liu, Y.; Lu, L.; Yang, R.; Yu, G.; Sun, M.; Xin, S.; Tian, S.; Chen, X.; Zhao, H. An Approach to Characterizing the Complicated Sequential Metabolism of Salidroside in Rats. Molecules 2016, 21, 706.

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