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Open AccessArticle

Bioassay-Guided Isolation of Cytotoxic Isocryptoporic Acids from Cryptoporus volvatus

by Ling-Yun Zhou 1,2, Xiao-Hong Yu 1, Bin Lu 1 and Yan Hua 1,*
1
Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China, Southwest Forestry University, Kunming 650224, China
2
School of Pharmacy, Wannan Medical College, Wuhu 241002, China
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Molecules 2016, 21(12), 1692; https://doi.org/10.3390/molecules21121692
Received: 19 October 2016 / Revised: 3 December 2016 / Accepted: 6 December 2016 / Published: 8 December 2016
(This article belongs to the Section Natural Products Chemistry)
The present work constitutes a contribution to the phytochemical investigation of Cryptoporus volvatus aiming to search for effective cytotoxic constituents against tumor cell lines in vivo. Bioassay-guided separation of the ethylacetate extract of C. volvatus afforded four new isocryptoporic acid (ICA) derivatives, ICA-B trimethyl ester (1), ICA-E (2), ICA-E pentamethyl ester (3), and ICA-G (4), together with nine known cryptoporic acids. These isocryptoporic acids are isomers of the cryptoporic acids with drimenol instead of albicanol as the terpenoid fragment; their structures were elucidated on the basis of spectroscopic evidences (UV, IR, HRMS, and NMR) and comparison with literature values. All isolates show certain cytotoxic activities against five tumor cell lines. Among them, compound 4 showed an comparable activity to that of the positive control cis-platin, while other compounds exhibited weak cytotoxic activities. View Full-Text
Keywords: Cryptoporus volvatus; isocryptoporic acids; cytotoxic activities against cancer cell lines Cryptoporus volvatus; isocryptoporic acids; cytotoxic activities against cancer cell lines
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MDPI and ACS Style

Zhou, L.-Y.; Yu, X.-H.; Lu, B.; Hua, Y. Bioassay-Guided Isolation of Cytotoxic Isocryptoporic Acids from Cryptoporus volvatus. Molecules 2016, 21, 1692.

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