Next Article in Journal
Metal-Free Photoredox Catalyzed Cyclization of O-(2,4-Dinitrophenyl)oximes to Phenanthridines
Previous Article in Journal
Extract of Monascus purpureus CWT715 Fermented from Sorghum Liquor Biowaste Inhibits Migration and Invasion of SK-Hep-1 Human Hepatocarcinoma Cells
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle

Bioassay-Guided Isolation of Cytotoxic Isocryptoporic Acids from Cryptoporus volvatus

Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China, Southwest Forestry University, Kunming 650224, China
School of Pharmacy, Wannan Medical College, Wuhu 241002, China
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Molecules 2016, 21(12), 1692;
Received: 19 October 2016 / Revised: 3 December 2016 / Accepted: 6 December 2016 / Published: 8 December 2016
(This article belongs to the Section Natural Products Chemistry)
PDF [381 KB, uploaded 13 December 2016]


The present work constitutes a contribution to the phytochemical investigation of Cryptoporus volvatus aiming to search for effective cytotoxic constituents against tumor cell lines in vivo. Bioassay-guided separation of the ethylacetate extract of C. volvatus afforded four new isocryptoporic acid (ICA) derivatives, ICA-B trimethyl ester (1), ICA-E (2), ICA-E pentamethyl ester (3), and ICA-G (4), together with nine known cryptoporic acids. These isocryptoporic acids are isomers of the cryptoporic acids with drimenol instead of albicanol as the terpenoid fragment; their structures were elucidated on the basis of spectroscopic evidences (UV, IR, HRMS, and NMR) and comparison with literature values. All isolates show certain cytotoxic activities against five tumor cell lines. Among them, compound 4 showed an comparable activity to that of the positive control cis-platin, while other compounds exhibited weak cytotoxic activities. View Full-Text
Keywords: Cryptoporus volvatus; isocryptoporic acids; cytotoxic activities against cancer cell lines Cryptoporus volvatus; isocryptoporic acids; cytotoxic activities against cancer cell lines

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zhou, L.-Y.; Yu, X.-H.; Lu, B.; Hua, Y. Bioassay-Guided Isolation of Cytotoxic Isocryptoporic Acids from Cryptoporus volvatus. Molecules 2016, 21, 1692.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top