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Open AccessArticle

New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris

Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
Department of Neurosurgery, Xiamen Chang Gung Memorial Hospital, Xiamen 361028, China
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 40447, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Derek J. McPhee and John Beutler
Molecules 2015, 20(7), 13205-13215;
Received: 24 June 2015 / Revised: 15 July 2015 / Accepted: 17 July 2015 / Published: 21 July 2015
(This article belongs to the Section Natural Products Chemistry)
Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 13 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 14 against a panel of tumor cells is also described. View Full-Text
Keywords: Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity
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Hsiao, T.-H.; Cheng, C.-H.; Wu, T.-Y.; Lu, M.-C.; Chen, W.-F.; Wen, Z.-H.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris. Molecules 2015, 20, 13205-13215.

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