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Open AccessArticle

New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
3
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
4
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
5
Department of Neurosurgery, Xiamen Chang Gung Memorial Hospital, Xiamen 361028, China
6
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
7
Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
10
Center for Molecular Medicine, China Medical University Hospital, Taichung 40447, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Derek J. McPhee and John Beutler
Molecules 2015, 20(7), 13205-13215; https://doi.org/10.3390/molecules200713205
Received: 24 June 2015 / Revised: 15 July 2015 / Accepted: 17 July 2015 / Published: 21 July 2015
(This article belongs to the Section Natural Products Chemistry)
Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 13 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 14 against a panel of tumor cells is also described. View Full-Text
Keywords: Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity
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Hsiao, T.-H.; Cheng, C.-H.; Wu, T.-Y.; Lu, M.-C.; Chen, W.-F.; Wen, Z.-H.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris. Molecules 2015, 20, 13205-13215.

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