Next Article in Journal
Novel Zinc-Catalytic Systems for Ring-Opening Polymerization of ε-Caprolactone
Next Article in Special Issue
Distribution and Evolution of the Lectin Family in Soybean (Glycine max)
Previous Article in Journal
Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation
Previous Article in Special Issue
Emerging Structural Insights into Glycoprotein Quality Control Coupled with N-Glycan Processing in the Endoplasmic Reticulum
Article Menu

Export Article

Open AccessReview
Molecules 2015, 20(2), 2802-2815;

Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface

Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Dr. Balmis #148, Col. Doctores, C.P. 06726 Mexico, D.F., Mexico
Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 16 November 2014 / Accepted: 13 January 2015 / Published: 9 February 2015
(This article belongs to the Special Issue Lectins)
Full-Text   |   PDF [685 KB, uploaded 13 February 2015]


Entamoeba histolytica is the causative agent of amebiasis in humans and is responsible for 100,000 deaths annually, making it the third leading cause of death due to a protozoan parasite. Pathogenesis appears to result from the potent cytotoxic activity of the parasite, which kills host cells within minutes. Although the mechanism is unknown, it is well established to be contact-dependent. The life cycle of the parasite alternates with two forms: the resistant cyst and the invasive trophozoite. The adhesive interactions between the parasite and surface glycoconjugates of host cells, as well as those lining the epithelia, are determinants for invasion of human tissues, for its cytotoxic activity, and finally for the outcome of the disease. In this review we present an overview of the information available on the amebic lectins and adhesins that are responsible of those adhesive interactions and we also refer to their effect on the host immune response. Finally, we present some concluding remarks and perspectives in the field. View Full-Text
Keywords: Entamoeba histolytica; lectins; adhesins; cytotoxicity Entamoeba histolytica; lectins; adhesins; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Aguirre García, M.; Gutiérrez-Kobeh, L.; López Vancell, R. Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface. Molecules 2015, 20, 2802-2815.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top