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Molecules 2015, 20(1), 348-357;

Marine Sponge Lectins: Actual Status on Properties and Biological Activities

Laboratório de Proteômica Estrutural, Departamento de Biologia Molecular, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa, PB CEP 58059-900, Brazil
Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte, Centro, Santa Cruz, RN CEP 5900000, Brazil
Engenharia de Pesca, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/nº, São Cristóvão, SE CEP 49100000, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 15 September 2014 / Accepted: 18 December 2014 / Published: 26 December 2014
(This article belongs to the Special Issue Lectins)
Full-Text   |   PDF [1449 KB, uploaded 26 December 2014]   |  


Marine sponges are primitive metazoans that produce a wide variety of molecules that protect them against predators. In studies that search for bioactive molecules, these marine invertebrates stand out as promising sources of new biologically-active molecules, many of which are still unknown or little studied; thus being an unexplored biotechnological resource of high added value. Among these molecules, lectins are proteins that reversibly bind to carbohydrates without modifying them. In this review, various structural features and biological activities of lectins derived from marine sponges so far described in the scientific literature are discussed. From the results found in the literature, it could be concluded that lectins derived from marine sponges are structurally diverse proteins with great potential for application in the production of biopharmaceuticals, especially as antibacterial and antitumor agents. View Full-Text
Keywords: marine sponge; lectins; properties; biological activities marine sponge; lectins; properties; biological activities

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Gomes Filho, S.M.; Cardoso, J.D.; Anaya, K.; Silva do Nascimento, E.; de Lacerda, J.T.J.G.; Mioso, R.; Santi Gadelha, T.; de Almeida Gadelha, C.A. Marine Sponge Lectins: Actual Status on Properties and Biological Activities. Molecules 2015, 20, 348-357.

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