N,N'-bis[(3,4-Dichlorophenyl)methyl]ethanediamide

doi:10.3390/M3

Molecules1997, 2(4), M3;https://doi.org/10.3390/M3

This article belongs to the Section Molbank Section of Molecules, 1997-2001

A solution of K₂CO₃ (2.39g, 17.3 mmol) in water (5 ml) was added to a mixture of N-(3,4-dichlorophenyl)methyl oxamic acid ethyl ester [1] (0.955 g, 3.46 mmol), 3,4-dichlorobenzylamonium chloride (1.0504 g, 3.80 mmol) in diethyl ether (100 ml) and stirred at r.t. overnight. The suspension was dissolved with EtOAc (80ml). The mixture was washed with HCl (0.001N, 100ml) water (2x100ml) and quickly dried (Na₂SO₄). A white precipitate formed after standing at r.t. Yield 0.1g (7%) of a white solid.

M.p. 213-214deg.C.

¹H-NMR ((D₆)DMSO): 9.41 (t, 2H, NH); 7.58 (d, 1H, HC(6)); 7.52 (d, 1H, HC(2)); 7.25 (q, 1H, HC(5)); 4.32 (d, 4H, CH₂).

MS: 404 (M⁺, containing 4Cl); 245, 174, 159.

Supplementary materials

Supplementary File 1Supplementary File 2

Acknowledgments

The author would like to thank Dr. Vittorio Rasetti for his support.

References

Lin, S.-K. N-(3,4-Dichlorophenyl)methyl oxamic acid ethyl ester. Molecules 1997, 2, M2. [Google Scholar] [CrossRef]

Sample Availability: Not available.

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