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Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy
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Molecules 2014, 19(8), 11505-11519; https://doi.org/10.3390/molecules190811505
Received: 30 June 2014 / Revised: 15 July 2014 / Accepted: 21 July 2014 / Published: 4 August 2014
(This article belongs to the Section Organic Chemistry)
By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. View Full-Text
Keywords: aziridines; boron compounds; Suzuki-Miyaura; palladium coupling; antibiotics aziridines; boron compounds; Suzuki-Miyaura; palladium coupling; antibiotics
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MDPI and ACS Style

Giovine, A.; Muraglia, M.; Florio, M.A.; Rosato, A.; Corbo, F.; Franchini, C.; Musio, B.; Degennaro, L.; Luisi, R. Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents. Molecules 2014, 19, 11505-11519. https://doi.org/10.3390/molecules190811505

AMA Style

Giovine A, Muraglia M, Florio MA, Rosato A, Corbo F, Franchini C, Musio B, Degennaro L, Luisi R. Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents. Molecules. 2014; 19(8):11505-11519. https://doi.org/10.3390/molecules190811505

Chicago/Turabian Style

Giovine, Arianna; Muraglia, Marilena; Florio, Marco A.; Rosato, Antonio; Corbo, Filomena; Franchini, Carlo; Musio, Biagia; Degennaro, Leonardo; Luisi, Renzo. 2014. "Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents" Molecules 19, no. 8: 11505-11519. https://doi.org/10.3390/molecules190811505

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