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Molecules 2014, 19(12), 20880-20887;

Two New Coumarins from Talaromyces flavus

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 22 October 2014 / Revised: 28 November 2014 / Accepted: 9 December 2014 / Published: 12 December 2014
(This article belongs to the Section Natural Products Chemistry)
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Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins. View Full-Text
Keywords: Talaromyces flavus; coumarin; structure elucidation; biological activities Talaromyces flavus; coumarin; structure elucidation; biological activities

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He, J.-W.; Qin, D.-P.; Gao, H.; Kuang, R.-Q.; Yu, Y.; Liu, X.-Z.; Yao, X.-S. Two New Coumarins from Talaromyces flavus. Molecules 2014, 19, 20880-20887.

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