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Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 20864-20879;
Received: 21 October 2014 / Revised: 5 December 2014 / Accepted: 8 December 2014 / Published: 12 December 2014
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
This review is an attempt to summarize our current understanding of curcumin’s potential as a neuroprotectant and an antidepressant. This dual property confers a unique advantage to this herbal medication, believed to be devoid of any major side effects, to combat commonly observed co-morbid conditions of a neurodegenerative and a neuropsychiatric disorder. Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Thus, following a brief introduction of curcumin’s pharmacology, we present research suggesting how its anti-inflammatory properties have therapeutic potential in treating a devastating neurological disorder (Parkinson’s disease = PD) and a debilitating neuropsychiatric disorder (major depressive disorder = MDD). It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression. View Full-Text
Keywords: curcumin; inflammation; depression; Parkinson’s disease; neuroprotection curcumin; inflammation; depression; Parkinson’s disease; neuroprotection
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Tizabi, Y.; Hurley, L.L.; Qualls, Z.; Akinfiresoye, L. Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression. Molecules 2014, 19, 20864-20879.

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