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Molecules 2013, 18(11), 13175-13187;

Physiological Effects of l-Theanine on Drosophila melanogaster

Department of Interventional Radiology, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China
These authors contribute equally to this work.
Authors to whom correspondence should be addressed.
Received: 8 August 2013 / Revised: 15 October 2013 / Accepted: 15 October 2013 / Published: 24 October 2013
(This article belongs to the Section Natural Products Chemistry)
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Green tea has been consumed as the most popular drink in East Asia for centuries, and is believed to have a wide range of health benefits. l-Theanine, the major component of the free amino acids in green tea, has been reported to display neuronal protection and tumor inhibition in vitro, but its physiological effects on animal development and behavior remain elusive. In this report, we used Drosophila melanogaster, the fruit fly, as a model organism to investigate the physiological effects of L-theanine. Flies were fed with three different concentrations of theanine as a dietary supplement after eclosion, and were examined for a variety of physiological parameters at different time points. We found theanine treatment results in significantly increased locomotion and courtship ability, and decreased resistance against wet and dry starvation in males, but not in females. Furthermore, theanine application diminished UV tolerance in females, but not in males. However, we did not perceive distinguishable effect of theanine on animal development, life span, weight, and tolerance of heat and anoxia. This work represents the first comprehensive physiological investigation of L-theanine at the whole animal level, and shall shed light on the mechanistic study of theanine in the future. View Full-Text
Keywords: l-theanine; Drosophila melanogaster; locomotion; courtship; starvation l-theanine; Drosophila melanogaster; locomotion; courtship; starvation

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Yang, H.; Li, W.; Yu, H.; Yuan, R.; Yang, Y.; Pung, K.; Li, P.; Xue, L. Physiological Effects of l-Theanine on Drosophila melanogaster. Molecules 2013, 18, 13175-13187.

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