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Open AccessArticle

N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
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Molecules 2012, 17(8), 9413-9420; https://doi.org/10.3390/molecules17089413
Received: 5 July 2012 / Revised: 27 July 2012 / Accepted: 30 July 2012 / Published: 6 August 2012
A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed. View Full-Text
Keywords: pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella pridazin-3(2H)-one; synthesis; insecticidal activity; SAR study; Plutella xylostella
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MDPI and ACS Style

Wu, J.; Kang, S.; Yuan, Q.; Luo, L.; Ma, J.; Shi, Q.; Yang, S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules 2012, 17, 9413-9420. https://doi.org/10.3390/molecules17089413

AMA Style

Wu J, Kang S, Yuan Q, Luo L, Ma J, Shi Q, Yang S. N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study. Molecules. 2012; 17(8):9413-9420. https://doi.org/10.3390/molecules17089413

Chicago/Turabian Style

Wu, Jian; Kang, Shenghong; Yuan, Qinkun; Luo, Lijun; Ma, Juan; Shi, Qingcai; Yang, Song. 2012. "N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study" Molecules 17, no. 8: 9413-9420. https://doi.org/10.3390/molecules17089413

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