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Open AccessArticle

Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
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Molecules 2012, 17(10), 11469-11483; https://doi.org/10.3390/molecules171011469
Received: 24 August 2012 / Revised: 18 September 2012 / Accepted: 20 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue Solvent-Free Synthesis)
Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation. View Full-Text
Keywords: aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium
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Onitsuka, S.; Jin, Y.Z.; Shaikh, A.C.; Furuno, H.; Inanaga, J. Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions. Molecules 2012, 17, 11469-11483.

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