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The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea
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Molecules 2012, 17(10), 11484-11494; https://doi.org/10.3390/molecules171011484
Received: 4 July 2012 / Revised: 28 August 2012 / Accepted: 21 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue Antioxidants 2012)
Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity. View Full-Text
Keywords: Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC
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Choe, K.I.; Kwon, J.H.; Park, K.H.; Oh, M.H.; Kim, M.H.; Kim, H.H.; Cho, S.H.; Chung, E.K.; Ha, S.Y.; Lee, M.W. The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR. Molecules 2012, 17, 11484-11494.

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