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Molecules 2010, 15(12), 9174-9183;

Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Chinese People’s Armed Police Forces, Tianjin Provincial Corps Hospital, Tianjin 300162, China
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Author to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 7 December 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Structure-Based Drug Design)
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A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents. View Full-Text
Keywords: trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhu, Y.; Zhang, Y.; Liu, Y.; Chu, H.; Duan, H. Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents. Molecules 2010, 15, 9174-9183.

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