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Open AccessArticle

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

1
Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China
2
Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2009, 14(12), 5042-5053; https://doi.org/10.3390/molecules14125042
Received: 26 October 2009 / Revised: 25 November 2009 / Accepted: 2 December 2009 / Published: 7 December 2009
A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC50 values of 11.6 and 6.1 mM, respectively. View Full-Text
Keywords: PBTs; synthesis; cytotoxicity PBTs; synthesis; cytotoxicity
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Li, S.; Han, L.; Sun, L.; Zheng, D.; Liu, J.; Fu, Y.; Huang, X.; Wang, Z. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules 2009, 14, 5042-5053.

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