Molecules 2008, 13(9), 2313-2325; https://doi.org/10.3390/molecules13092313
Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions
Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC
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Received: 22 August 2008 / Revised: 10 September 2008 / Accepted: 10 September 2008 / Published: 25 September 2008
Abstract
2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method. View Full-TextKeywords:
Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines
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Kuo, C.-W.; Wang, C.-C.; Kavala, V.; Yao, C.-F. Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions. Molecules 2008, 13, 2313-2325.
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