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Molecules 2007, 12(4), 832-841;

Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China
Author to whom correspondence should be addressed.
Received: 30 January 2007 / Revised: 2 April 2007 / Accepted: 3 April 2007 / Published: 23 April 2007
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Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells. View Full-Text
Keywords: Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity Platycodon grandiflorum; Triterpenoid saponins; cytotoxic activity

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Zhang, L.; Liu, Z.-H.; Tian, J.-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules 2007, 12, 832-841.

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