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Open AccessArticle

Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana

Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli – via Vivaldi 43, I-81100 Caserta, Italy
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Molecules 2007, 12(2), 263-270; https://doi.org/10.3390/12020263
Received: 21 January 2007 / Revised: 13 February 2007 / Accepted: 27 February 2007 / Published: 28 February 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-β-D-gluco-pyranosyloxy-4',5-dihydroxy-3-[O-α-L-rhamnopyranosyl-(1→6)-3-O-β-D-glucopyrano-syloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker’s synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5. View Full-Text
Keywords: Melilotus neapolitana Ten; flavone glycosides; ROSs; antioxidant activity Melilotus neapolitana Ten; flavone glycosides; ROSs; antioxidant activity
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Fiorentino, A.; D'Abrosca, B.; Pacifico, S.; Golino, A.; Mastellone, C.; Oriano, P.; Monaco, P. Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana. Molecules 2007, 12, 263-270.

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