Next Article in Journal
Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics
Previous Article in Journal
Antioxidant Activity and Total Phenols in Different Extracts of Four Staphylea L. Species
Open AccessArticle

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

1
Department of Organic Chemistry and Biochemistry and 4 Department of Inorganic Chemistry; Faculty of Chemistry, “Al. I. Cuza” University, Bd. Carol I, no. 11, 700506 Iasi, Romania
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Gr. T. Popa” Medicine and Pharmacy University, Universitatii Street, no. 16, 700115 Iasi, Romania
3
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering, “Gh. Asachi” Technical University, Bd. Mangeron, no. 71A, 700050, Iasi, Romania
*
Author to whom correspondence should be addressed.
Molecules 2007, 12(1), 103-113; https://doi.org/10.3390/12010103
Received: 4 December 2006 / Revised: 25 January 2007 / Accepted: 26 January 2007 / Published: 29 January 2007
New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus. View Full-Text
Keywords: 1;3;4-Thiadiazole; 1;2;4-triazole; thiosemicarbazide; D;L-methionine; antimicrobial activity 1;3;4-Thiadiazole; 1;2;4-triazole; thiosemicarbazide; D;L-methionine; antimicrobial activity
Show Figures

Figure 1

MDPI and ACS Style

Pintilie, O.; Profire, L.; Sunel, V.; Popa, M.; Pui, A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules 2007, 12, 103-113.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop