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Open AccessArticle

Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics

Ghent University, Department of Organic Chemistry, Laboratory for Organic and Biomimetic Chemistry, Krijgslaan 281 (S4), B-9000 Gent, Belgium
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Molecules 2007, 12(1), 114-129; https://doi.org/10.3390/12010114
Received: 21 December 2006 / Revised: 29 January 2007 / Accepted: 30 January 2007 / Published: 31 January 2007
The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic. View Full-Text
Keywords: Nucleoside synthesis; serine protease mimic; DNA scaffold; 2� modification. Nucleoside synthesis; serine protease mimic; DNA scaffold; 2� modification.
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Catry, M.A.; Madder, A. Synthesis of Functionalised Nucleosides for Incorporation into Nucleic Acid-Based Serine Protease Mimics. Molecules 2007, 12, 114-129.

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