Pharmaceutical Application of Magnetic Iron Oxide Nanoparticles

Dear Colleagues,

In the field of nanotechnology, recent decades have witnessed the emergence of many nanosystems exhibiting customized properties, which are of major interest for many applications. Among the existing nanomaterials, superparamagnetic iron oxide nanoparticles (SPIO) have emerged as promising thanks to their remarkable magnetic properties, especially for biomedical applications, where their efficiency as a contrast enhancer for magnetic resonance imaging (MRI) has been widely documented. The development of emerging technologies, such as magnetic hyperthermia, cell tracking, drug delivery, molecular imaging, or, more recently, magnetic particle imaging (MPI), has encouraged the continued development of reliable procedures to produce nanoparticles exhibiting desirable properties. This Topic explores the potential of magnetic nanoconstructs in biomedicine. Potential topics include, but are not limited to:

• SPIO development, synthesis, and characterization for biomedical applications;
• Surface modification/functionalization for biomedical applications, including molecular and multimodal imaging;
• Scale-up, reproducibility, and qualification of nanoparticle batches produced for biomedical applications;
• Original approaches for the synthesis of magnetic nanoparticles intended for biomedical applications;
• Evaluation of particles’ toxicity/innocuity, including the development of original models;
• The use of SPIO for innovative imaging modalities (e.g. magnetic particle imaging, MSOT, etc.);
• The evaluation of their potential as therapeutic agents alone, or in combination (e.g., radiosensitizing properties, drug delivery, etc.).

Dr. Dimitri Stanicki
Prof. Dr. Sophie Laurent
Topic Editors