Topic Editors

1. “G. Scansetti” Interdepartmental Centre for Studies on Asbestos and Other Toxic Particulates, University of Torino, Via Pietro Giuria 7, I-10125 Torino, Italy
2. Department of Chemistry, University of Torino, Via Pietro Giuria 7, I-10125 Torino, Italy
Department of Oncology, University of Torino, Torino, Italy

Molecular Mechanisms of the Toxicity and Carcinogenicity of Particulates

Abstract submission deadline
closed (30 May 2023)
Manuscript submission deadline
30 July 2023
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2733

Topic Information

Dear Colleagues,

We are pleased to inform you that we are planning a Topic on the molecular mechanisms of the toxicity and carcinogenicity of particulates. Particles and fibers affect human health as a function of their physicochemical properties, but both the mechanisms of action and link between physicochemical features and adverse responses are still often unclear. Knowledge of these mechanisms is fundamental for hazard identification and the development of new testing approaches as well as safe-by-design practices. This Topic aims to increase knowledge about the mechanisms of toxicity and role of physicochemical properties in the induction of adverse responses. Given your expertise in the field, we would like to invite you to send us a contribution. Original research articles (in vitro and in vivo studies) and reviews are welcome. Research areas may include (but are not limited to) particles and fibers of natural origin (asbestos and fibrous minerals, silica, volcanic ashes, and celestial dusts) and anthropic origin (artificial fibers, carbon nanotubes, titanium dioxide, particulate matter, metals, etc.), as well as the nanoparticles comprising them. We look forward to receiving your contributions.

Dr. Maura Tomatis
Dr. Elisabetta Aldieri
Topic Editors

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biology
biology
5.168 2.8 2012 16.1 Days 2200 CHF Submit
Cancers
cancers
6.575 5.8 2009 17.4 Days 2600 CHF Submit
Healthcare
healthcare
3.160 2.0 2013 19.1 Days 2000 CHF Submit
Onco
onco
- - 2021 15.0 days * 1000 CHF Submit
Pathophysiology
pathophysiology
- 4.3 1994 16.3 Days 1400 CHF Submit
Toxics
toxics
4.472 3.7 2013 14.9 Days 2000 CHF Submit
Biomolecules
biomolecules
6.064 5.7 2011 16.6 Days 2300 CHF Submit
International Journal of Molecular Sciences
ijms
6.208 6.9 2000 15.9 Days 2500 CHF Submit

* Median value for all MDPI journals in the second half of 2022.


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Published Papers (2 papers)

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Article
Top-Down Preparation of Nanoquartz for Toxicological Investigations
Int. J. Mol. Sci. 2022, 23(23), 15425; https://doi.org/10.3390/ijms232315425 - 06 Dec 2022
Viewed by 930
Abstract
Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the overall toxicity of quartz is still largely unexplored, [...] Read more.
Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the overall toxicity of quartz is still largely unexplored, primarily because of the strong electrostatic adhesion forces that prevent isolation of the nanofraction. Furthermore, fractured silica dust exhibits special surface features, namely nearly free silanols (NFS), which impart a membranolytic activity to quartz. Nanoquartz can be synthetized via bottom-up methods, but the surface chemistry of such crystals strongly differs from that of nanoparticles resulting from fracturing. Here, we report a top-down milling procedure to obtain a nanometric quartz that shares the key surface properties relevant to toxicity with fractured quartz. The ball milling was optimized by coupling the dry and wet milling steps, using water as a dispersing agent, and varying the milling times and rotational speeds. Nanoquartz with a strong tendency to form submicrometric agglomerates was obtained. The deagglomeration with surfactants or simulated body fluids was negligible. Partial lattice amorphization and a bimodal crystallite domain size were observed. A moderate membranolytic activity, which correlated with the number of NFS, signaled coherence with the previous toxicological data. A membranolytic nanoquartz for toxicological investigations was obtained. Full article
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Article
Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis
Toxics 2022, 10(11), 694; https://doi.org/10.3390/toxics10110694 - 16 Nov 2022
Viewed by 986
Abstract
Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the possible abnormalities in hematopoietic function 20 weeks after intratracheal instillation of PHMG-p in [...] Read more.
Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the possible abnormalities in hematopoietic function 20 weeks after intratracheal instillation of PHMG-p in a rat model. Notable abnormalities were found out in the peripheral blood cell count and bone marrow (BM) biopsy, while RNA sequencing of BM tissue revealed markedly altered gene expression. Furthermore, signaling involved in hematopoietic dysfunction was predicted by analyzing candidate genes through Ingenuity Pathway Analysis (IPA) program. Respiratory PHMG-p exposure significantly decreased monocyte and platelet (PLT) counts and total protein, while significantly increasing hemoglobin and hematocrit levels in peripheral blood. Histopathological analysis of the BM revealed a reduced number of megakaryocytes, with no significant differences in spleen and liver weight to body weight. Moreover, PHMG-p exposure significantly activated estrogen receptor signaling and RHOA signaling, and inhibited RHOGDI signaling. In IPA analysis, candidate genes were found to be strongly related to ‘hematological system development and function’ and ‘hematological disease.’ Accordingly, our results suggest that PHMG-p could affect hematopoiesis, which participates in monocyte differentiation and PLT production, and may induce hematologic diseases via the respiratory tract. Full article
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