Search Results (1,164)

Ant venoms are rich sources of bioactive molecules, including peptide toxins with potent and selective activity on ion channels, which makes them valuable for pharmacological research and therapeutic development. Voltage-dependent potassium (Kv) channels, critical for regulating cellular excitability or cell cycle progression control, are targeted by a diverse array of venom-derived peptides. This study focuses on MYRTX_A4-Tb11a, a peptide from Tetramorium bicarinatum venom, which was previously shown to have a strong paralytic effect on dipteran species without cytotoxicity on insect cells. In the present study, we show that Tb11a exhibited no or low cytotoxicity toward mammalian cells either, even at high concentrations, while electrophysiological studies revealed a blockade of hKv1.3 activity. Additionally, Ta11a, an analog of Tb11a from the ant Tetramorium africanum, demonstrated similar Kv1.3 inhibitory properties. Structural analysis supports that the peptide acts on Kv1.3 channels through the functional dyad Y21-K25 and that the disulfide bridge is essential for biological activity, as reduction seems to disrupt the peptide conformation and impair the dyad. These findings highlight the importance of three-dimensional structure in channel modulation and establish Tb11a and Ta11a as promising Kv1.3 inhibitors. Future research should investigate their selectivity across additional ion channels and employ structure-function studies to further enhance their pharmacological potential. Full article

Reaction bonding (RB) using Al powder is an effective method for preparing porous ceramics with low shrinkage, high porosity, and high strength. However, it remains challenging to optimize mechanical strength and oil conductivity simultaneously for atomizer applications. Herein, aiming at addressing this issue, porous Al₂O₃ ceramics with ultra-high mechanical strength and oil conductivity were fabricated via the RB process using polymethyl methacrylate (PMMA) microspheres as the pore-forming agent. The pore structure was gradually optimized by regulating the additive amount, particle size, and particle gradation of PMMA microspheres. The bimodal pores, formed by Al oxidation-induced hollow structures (enhancing bonding force) and burnout of large-sized PMMA microspheres, significantly improved mechanical strength; meanwhile, three-dimensional interconnected pores derived from particle gradation increased the diversity and quantity of oil-conduction channels, boosting oil conductivity. Consequently, under an open porosity of 58.2 ± 0.1%, a high compressive strength of 7.9 ± 0.3 MPa (a 54.7% improvement) and an excellent oil conductivity of 2.1 ± 0.0 mg·s⁻¹ (a 46.5% improvement) were achieved. This superior performance combination, overcoming the trade-off between strength and oil conductivity, demonstrates substantial application potential in atomizers. Full article

This paper presents a three-dimensional (3D) free surface model to predict incompressible flow around a spur dike in a meandering channel bend, which is highly 3D due to the presence of curvature effects. The model solves the Reynolds-averaged Navier–Stokes (RANS) equations using an explicit projection method. The 3D grid system is built from a two-dimensional grid by adding dozens of horizontal layers in the vertical direction. Numerical simulations consider four test cases with different spur dike locations in the same meandering channel bend with the same Froude numbers as 0.22. Four turbulence models, the standard k-ε model, the k-ω model, the RNG k-ε model and a nonlinear k-ε model, are implemented in our three-dimensional free surface model. The performance of these turbulence models within the RANS framework is assessed. Comparisons between the model results and experimental data show that the nonlinear k-ε model behaves better than the three other models in general. Based on the results obtained by the nonlinear k-ε model, the highly 3D flow field downstream of the spur dike was revealed by presenting velocity vectors at representative cross-sections and streamlines at the surface and bottom layers. Meanwhile, the 3D characteristics of the downstream separation zone were also investigated. In addition, to highlight the advantage of the nonlinear turbulence model, comparisons of velocity vectors at representative cross-sections between the results obtained by the linear and nonlinear $k$-$\epsilon$ models are also presented. Full article

This paper studies deep reinforcement learning (DRL)-based joint resource allocation and three-dimensional (3D) trajectory optimization for unmanned aerial vehicle (UAV)–ground access point (GAP) cooperative non-orthogonal multiple access (NOMA) communication in Industrial Internet of Things (IIoT) systems. Cooperative and non-cooperative users adopt different signal transmission strategies to meet diverse, task-oriented, quality-of-service requirements. Specifically, the DRL framework based on the Soft Actor–Critic algorithm is proposed to jointly optimize user scheduling, power allocation, and UAV trajectory in continuous action spaces. Closed-form power allocation and maximum weight bipartite matching are integrated to enable efficient user pairing and resource management. Simulation results show that the proposed scheme significantly enhances system performance in terms of throughput, spectral efficiency, and interference management, while enabling robustness against channel uncertainties in dynamic IIoT environments. The findings indicate that combining model-free reinforcement learning with conventional optimization provides a viable solution for adaptive resource management in dynamic UAV-GAP cooperative communication scenarios. Full article

Alkaline electrolytic water hydrogen generation, a key driver in the growth of hydrogen energy, heavily relies on high-efficiency and high-purity ion exchange membranes. In this study, three-dimensional (3D) wrinkled reduced graphene oxide (WG) nanosheets obtained through a simple thermal reduction process and two-dimensional (2D) graphene oxide act as building blocks, with ethylenediamine as a crosslinking stabilizer, to construct a unique 3D/2D 2 nm-tunneling structure between the GO and WG sheets through via an amide connection at a WG/GO ratio of 1:1. Here, the wrinkled graphene (WG) undergoes a transition from two-dimensional (2D) graphene oxide (GO) into three-dimensional (3D) through the adjustment of surface energy. By increasing the interlayer spacing and the number of ion fluid channels within the membranes, the E-W/G membrane has achieved the rapid passage of hydroxide ions (OH⁻) and simultaneous isolation of produced gas molecules. Moreover, the dense 2 nm nano-tunneling structure in the electrolytic water process enables the E-W/G membrane to attain current densities >99.9% and an extremely low gas crossover rate of hydrogen and oxygen. This result suggests that the as-prepared membrane effectively restricts the unwanted crossover of gases between the anode and cathode compartments, leading to improved efficiency and reduced gas leakage during electrolysis. By enhancing the purity of the hydrogen production industry and facilitating the energy transition, our strategy holds great potential for realizing the widespread utilization of hydrogen energy. Full article

Reconfigurable intelligent surfaces (RISs), recognized as one of the most promising key technologies for sixth-generation (6G) mobile communications, are characterized by their minimal energy expenditure, cost-effectiveness, and straightforward implementation. In this study, we develop a novel communication channel model that integrates RIS-enabled base stations with unmanned ground vehicles. To enhance the system’s adaptability, we implement a fluid antenna system (FAS) at the unmanned ground vehicle (UGV) terminal. This innovative model demonstrates exceptional versatility across various wireless communication scenarios through the strategic adjustment of active ports. The inherent dynamic reconfigurability of the FAS provides superior flexibility and adaptability in air-to-ground communication environments. In the paper, we derive and study key performance characteristics like the autocorrelation function (ACF), validating the model’s effectiveness. The results demonstrate that the RIS-FAS collaborative scheme significantly enhances channel reliability while effectively addressing critical challenges in 6G networks, including signal blockage and spatial constraints in mobile terminals. Full article

The charge structure and lightning activities during the development stage of a thunderstorm with a hail-falling process in Datong County of Qinghai Province on 16 August 2014 were studied by using a multi-station observation network composed of a very-high-frequency, three-dimensional, lightning-radiation-source location system and broadband electric field. The research results show that two discharge regions appeared during the development stage of the thunderstorm. The charge structure was all a negative dipolar polarity in two discharge regions; however, the heights of the charge regions were different. The positive-charge region at a height of 2–3.5 km corresponds to −1–−10 °C and the negative-charge region at a height of 3.5–5 km corresponds to −11–−21 °C in one discharge region; the positive-charge region at a height of 4–5 km corresponds to −15–−21 °C and the negative-charge region at a height of 5–6 km corresponds to −21–−29 °C in another region. The charge regions with the same polarity at different heights in the two discharge regions gradually connected with the occurrence of the hail-falling process during the development stage of the thunderstorm, and the overall height of the charge regions decreased. All the intracloud lightning flashes that occurred in the thunderstorm were of inverted polarity discharge, and the horizontal transmission distance of the discharge channel was short, all within 10 km. The negative intracloud lightning flash, negative cloud-to-ground lightning flash, and positive cloud-to-ground lightning flash generated during the thunderstorm process accounted for 83%, 16%, and 1% of the total number of lightning flashes, respectively. Negative cloud-to-ground lightning flashes mainly occurred more frequently in the early phase of the thunderstorm development stage. As the thunderstorm developed, the frequency of intracloud lightning flashes became greater than that of negative cloud-to-ground lightning flashes, and finally far exceeded it. The frequency of lightning flashes decreases sharply and the intensity of thunderstorms decreases during the hail-falling period. Full article

Hydraulic fracturing is a crucial technology for developing unconventional oil and gas resources. However, conventional geophysical methods struggle to efficiently and accurately image proppant-connected channels created by hydraulic fracturing. The borehole-to-surface electromagnetic imaging method (BSEM) overcomes this limitation by utilizing a controlled cased well source. Placing the source close to the target reservoir and deploying multi-component receivers on the surface enable high-precision lateral monitoring, providing an effective approach for dynamic monitoring of hydraulic fracturing operations. This study focuses on key aspects of forward modeling for BSEM. A three-dimensional finite-volume method based on the Yee grid was used to simulate the borehole-to-surface electromagnetic system incorporating metal casings, validating the method of simulating metal casing using multiple line sources. The simulation of the observation system and the frequency-domain electromagnetic monitoring simulation based on actual well data confirm BSEM’s high sensitivity for monitoring deep subsurface formations. Critically, well casing exerts a substantial influence on surface electromagnetic responses, while the electromagnetic contribution from line sources emulating perforation zones necessitates explicit incorporation within data processing workflows. Full article

Hemoglobin plays a critical role in diagnosing various medical conditions, including infections, trauma, hemolytic disorders, and Mediterranean anemia, which is particularly prevalent in Mediterranean populations. Conventional measurement methods require blood sampling and laboratory analysis, which are often time-consuming and impractical during emergency situations with limited medical infrastructure. Although portable oximeters enable non-invasive hemoglobin estimation, they still require physical contact, posing limitations for individuals with circulatory or dermatological conditions. Additionally, reliance on disposable probes increases operational costs. This study presents a non-contact and automated approach for estimating total hemoglobin levels from facial video data using three-dimensional regression models. A dataset was compiled from 279 volunteers, with synchronized acquisition of facial video and hemoglobin values using a commercial pulse oximeter. After preprocessing, the dataset was divided into training, validation, and test subsets. Three 3D convolutional regression models, including 3D CNN, channel attention-enhanced 3D CNN, and residual 3D CNN, were trained, and the most successful model was implemented in a graphical interface. Among these, the residual model achieved the most favorable performance on the test set, yielding an RMSE of 1.06, an MAE of 0.85, and a Pearson correlation coefficient of 0.73. This study offers a novel contribution by enabling contactless hemoglobin estimation from facial video using 3D CNN-based regression techniques. Full article

Terahertz (THz) wireless communications can support ultra-high data rates and secure wireless links with miniaturized devices for unmanned aerial vehicle (UAV) communications. In this paper, a three-dimensional (3D) non-stationary geometry-based stochastic channel model (GSCM) is proposed for multiple-input multiple-output (MIMO) communication links between the UAVs in the THz band. The proposed channel model considers not only the 3D scattering and reflection scenarios (i.e., reflection and scattering fading) but also the atmospheric molecule absorption attenuation, arbitrary 3D trajectory, and antenna arrays of both terminals. In addition, the statistical properties of the proposed GSCM (i.e., the time auto-correlation function (T-ACF), space cross-correlation function (S-CCF), and Doppler power spectrum density (DPSD)) are derived and analyzed under several important UAV-related parameters and different carrier frequencies, including millimeter wave (mmWave) and THz bands. Finally, the good agreement between the simulated results and corresponding theoretical ones demonstrates the correctness of the proposed GSCM, and some useful observations are provided for the system design and performance evaluation of UAV-based air-to-air (A2A) THz-MIMO wireless communications. Full article

Various nature-based solutions (NbS)—such as constructed wetlands, drainage ditches, and vegetated buffer strips—have recently demonstrated strong potential for mitigating pollutant transport in open channels and river systems. Numerical modeling is a widely adopted and effective approach for assessing the performance of these interventions. This study presents the first development of a two-dimensional (2D) meshless advection–diffusion model based on an Eulerian smoothed particle hydrodynamics (SPH) framework, specifically designed to simulate passive pollutant transport in open channel flows. The proposed model marks a pioneering application of the ESPH technique to environmental pollutant transport problems. It couples the 2D depth-averaged shallow water equations with an advection–diffusion equation to represent both fluid motion and pollutant concentration dynamics. A uniform particle arrangement ensures that each fluid particle interacts symmetrically with eight neighboring particles for flux computation. To represent the pollutant transport process, the dispersion coefficient is defined as the sum of molecular and turbulent diffusion components. The turbulent diffusion coefficient is calculated using a prescribed turbulent Schmidt number and the eddy viscosity obtained from a Smagorinsky-type mixing-length turbulence model. Three analytical case studies, including one-dimensional transcritical open channel flow, 2D isotropic and anisotropic diffusion in still water, and advection–diffusion in a 2D uniform flow, are employed to verify the model’s accuracy and convergence. The model demonstrates first-order convergence, with relative root mean square errors (RRMSEs) of approximately 0.2% for water depth and velocity, and 0.1–0.5% for concentration. Additionally, the model is applied to a laboratory experiment involving 2D pollutant dispersion in a 90° junction channel. The simulated results show good agreement with measured velocity and concentration distributions. These findings indicate that the developed model is a reliable and effective tool for evaluating the performance of NbS in mitigating pollutant transport in open channels and river systems. Full article

Dark web traffic classification is an important research direction in cybersecurity; however, traditional classification methods have many limitations. Although deep learning architectures like CNN and LSTM, as well as multi-structural fusion frameworks, have demonstrated partial success, they remain constrained by shallow feature representation, localized decision boundaries, and poor generalization capacity. To improve the prediction accuracy and classification precision of dark web traffic, we propose a novel dark web traffic classification model integrating multi-channel image deep learning and a three-dimensional convolutional neural network (3D-CNN). The proposed framework leverages spatial–temporal feature fusion to enhance discriminative capability, while the 3D-CNN structure effectively captures complex traffic patterns across multiple dimensions. The experimental results show that compared to common 2D-CNN and 1D-CNN classification models, the dark web traffic classification method based on multi-channel image visual features and 3D-CNN can improve classification by 5.1% and 3.3% while maintaining a smaller total number of parameters and feature recognition parameters, effectively reducing the computational complexity of the model. In comparative experiments, 3D-CNN validates the model’s superiority in accuracy and computational efficiency compared to state-of-the-art methods, offering a promising solution for dark web traffic monitoring and security applications. Full article

In the present study, three-dimensional turbulent, subcritical open-channel flow (Fr = 0.19) through submerged rigid vegetation is numerically investigated using the ANSYS FLUENT solver (v. 22. 1). The Volume of Fluid (VOF) method is applied for free-surface tracking, while the standard k-ε turbulence model is employed for turbulence closure. Vegetation is modeled as vertical rigid cylinders fixed at the bottom of the channel. Regarding the arrangement of the stems, two cases are examined. In the first case, a linear arrangement of three equally spaced vegetative stems is located transversely at the center of the channel, while in the second case, a parallel arrangement of fifteen equidistant vegetative stems is located downstream of the channel center. In both cases, the vertical velocity profile within the submerged vegetation layer deviates significantly from that of the upper non-vegetated layer, which generally adheres to the logarithmic velocity distribution. In the second case, flow field repeatability is observed after the third stem series, particularly in terms of velocity profiles. Additionally, the structure of turbulence is noticeably affected in the vicinity of the stems, resulting in higher eddy viscosity values near each stem’s crest area. Furthermore, a localized drop in the free surface is recorded above the vegetated region, while a slight rise is observed upstream of each stem series, consistent with subcritical open-channel flow. Full article

Tunneling modes in all-dielectric one-dimensional photonic crystals can be utilized for multi-channel filtering. However, these tunneling modes generally blue shift upon increasing the incident angle. When hyperbolic metamaterials are introduced into one-dimensional photonic crystals, the competition between the propagation phase shifts in the dielectric materials and hyperbolic metamaterials can result in different angle dependencies, including blue shift, abnormal zero shift, and abnormal red shift. When the reduction in the propagation phase in the dielectric layer exceeds the increment in the propagation phase in the hyperbolic metamaterial, the tunneling modes are blue-shifted; conversely, when the phase increment in the hyperbolic metamaterial exceeds the phase reduction in the dielectric layer, the tunneling modes are abnormally red-shifted. When the phase changes in the two materials are the same, the tunneling modes are angle independent. In this study, we investigated the multiple filtering effects of one-dimensional photonic structures composed of hyperbolic metamaterials. These composed structures exhibited multiple tunneling modes based on one-, two-, or three-angle dependencies and can be applied in novel optical devices with different angle-dependence requirements. Full article

Against the backdrop of increasingly depleted global non-renewable resources, research on renewable energy has become urgently critical. As a significant marine clean energy source, tidal current energy has attracted growing scholarly interest, effectively addressing global energy shortages and fossil fuel pollution. Semi-enclosed bay straits, with their geographically advantageous topography, offer substantial potential for tidal energy exploitation. China’s Bohai Strait exemplifies such a geomorphological feature. This study focuses on the Bohai Strait, employing the Delft3D model to establish a three-dimensional numerical simulation of tidal currents in the region. Combined with the Flux tidal energy assessment method, the tidal energy resources are evaluated, and exploitation recommendations are proposed. The results demonstrate that the Laotieshan Channel, particularly its northern section, contains the most abundant tidal energy reserves in the Bohai Strait. The Laotieshan Channel has an average power flux density of 50.83 W/m², with a tidal energy potential of approximately 81,266.5 kW, of which about 12,189.97 kW is technically exploitable. Particularly in its northern section, favorable flow conditions exist—peak current speeds can reach 2 m/s, and the area offers substantial effective power generation hours. Annual durations with flow velocities exceeding 0.5 m/s total around 4500 h, making this zone highly suitable for deploying tidal turbines. To maximize the utilization of tidal energy resources, installation within the upper 20 m of the water layer is recommended. This study not only advances tidal energy research in semi-enclosed bay straits but also provides a critical reference for future studies, while establishing a foundational framework for practical tidal energy development in the Bohai Strait region. Full article