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Toxins
Special Issues
Unlocking the Deep Secrets of Toxins
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Unlocking the Deep Secrets of Toxins

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2167

Special Issue Editors

Dr. Pascale Marchot
*
E-Mail Website
Guest Editor
Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS/Aix-Marseille Université, Faculté des Sciences—Campus Luminy, F-13288 Marseille, CEDEX 09, France
Interests: animal toxins; biochemistry; enzymology; imine toxin; molecular toxinology; neurobiology; neuroscience; pathology; pharmacology; phycotoxins; physiology; snake venom; structure-function relationships; synapses
* Corresponding Editor
Special Issues, Collections and Topics in MDPI journals
Dr. Sylvie Diochot

E-Mail Website
Guest Editor
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS UMR7275, INSERM U1323, Sophia Antipolis, F-06560 Valbonne, France
Interests: animal toxins; animal venom; electrophysiology; ion channel; neurobiology; neuropharmacology; neurophysiology; neurotransmission; patch clamp
Special Issues, Collections and Topics in MDPI journals
Dr. Katia Comte

E-Mail Website
Guest Editor
Centre National de la Recherche Scientifique (CNRS)/Museum National d’Histoire Naturelle (MNHN), Molécules de Communication et Adaptation des Micro-Organismes, 75005 Paris, France
Interests: aquatic ecotoxicology; cyanotoxins; ecophysiology; harmful algal blooms; photosynthetic protists; stress responses; trophic interactions
Special Issues, Collections and Topics in MDPI journals
Dr. Michel R. Popoff
*
E-Mail Website
Guest Editor
Unité des Toxines Bactériennes, Institut Pasteur, Université Paris Cité, CNRS UMR 2001 INSERM U1306, F-75015 Paris, France
Interests: bacterial, botulinum, clostridial, and pore-forming toxins; cellular uptake; interactions with actin cytoskeleton; passage through epithelial barrier; regulation of synthesis; Rho-GTPases
* Corresponding Editor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural substances have been of interest for centuries, and many organic or peptidic toxins of bacterial, fungal, algal, plant, and animal origin have been identified, characterized, and used worldwide as poisons or weapons, drugs for medical conditions, probes for fundamental research, or tools for the industry.

In this Special Issue of the journal Toxins, entitled "Unlocking the Deep Secrets of Toxins", research and review articles concerning recent discoveries in the fields of animal venoms and of natural toxins and their derivatives will be presented to cover broad areas ranging from the discovery of new toxin producers and toxins in the environment and the analysis of their ecological, economical, and societal impacts, to the characterization of new toxins with original structural determinants, modes of actions, receptor-subtype specificities, and to their applicability in a health or biotechnological context, either directly or as molecular templates for the engineering of new compounds. This Special Issue is open, albeit not restricted, to all speakers and delegates of the 30th Meeting on Toxinology (RT30) organized by the French Society of Toxinology (SFET, http://sfet.asso.fr/international/) on December 02-03, 2024, at Hôtel Le Saint Paul in Nice, France.

Dr. Pascale Marchot
Dr. Sylvie Diochot
Dr. Katia Comte
Dr. Michel R. Popoff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • algal toxin
  • animal toxin
  • anti-toxin
  • anti-venom
  • bacterial toxin
  • contaminant
  • drug design
  • envenomation
  • environment
  • evolution
  • food chain
  • fungal toxin
  • genomics
  • health
  • ion channel
  • marine toxin
  • mechanism of action
  • plant toxin
  • production
  • proteomics
  • receptor
  • therapeutics
  • toxin engineering
  • toxinomics
  • toxin producer
  • structure-function relationship
  • screening
  • tool
  • trophic network
  • venom
  • venomics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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24 pages, 7561 KiB  
Review
Neurotoxins Acting on TRPV1—Building a Molecular Template for the Study of Pain and Thermal Dysfunctions
by Florian Beignon, Margaux Notais, Sylvie Diochot, Anne Baron, Ziad Fajloun, Hélène Tricoire-Leignel, Guy Lenaers and César Mattei
Toxins 2025, 17(2), 64; https://doi.org/10.3390/toxins17020064 - 31 Jan 2025
Viewed by 1129
Abstract
Transient Receptor Potential (TRP) channels are ubiquitous proteins involved in a wide range of physiological functions. Some of them are expressed in nociceptors and play a major role in the transduction of painful stimuli of mechanical, thermal, or chemical origin. They have been [...] Read more.
Transient Receptor Potential (TRP) channels are ubiquitous proteins involved in a wide range of physiological functions. Some of them are expressed in nociceptors and play a major role in the transduction of painful stimuli of mechanical, thermal, or chemical origin. They have been described in both human and rodent systems. Among them, TRPV1 is a polymodal channel permeable to cations, with a highly conserved sequence throughout species and a homotetrameric structure. It is sensitive to temperature above 43 °C and to pH below 6 and involved in various functions such as thermoregulation, metabolism, and inflammatory pain. Several TRPV1 mutations have been associated with human channelopathies related to pain sensitivity or thermoregulation. TRPV1 is expressed in a large part of the peripheral and central nervous system, most notably in sensory C and Aδ fibers innervating the skin and internal organs. In this review, we discuss how the transduction of nociceptive messages is activated or impaired by natural compounds and peptides targeting TRPV1. From a pharmacological point of view, capsaicin—the spicy ingredient of chilli pepper—was the first agonist described to activate TRPV1, followed by numerous other natural molecules such as neurotoxins present in plants, microorganisms, and venomous animals. Paralleling their adaptive protective benefit and allowing venomous species to cause acute pain to repel or neutralize opponents, these toxins are very useful for characterizing sensory functions. They also provide crucial tools for understanding TRPV1 functions from a structural and pharmacological point of view as this channel has emerged as a potential therapeutic target in pain management. Therefore, the pharmacological characterization of TRPV1 using natural toxins is of key importance in the field of pain physiology and thermal regulation. Full article
(This article belongs to the Special Issue Unlocking the Deep Secrets of Toxins)
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31 pages, 1249 KiB  
Conference Report
Report from the 30th Meeting on Toxinology, “Unlocking the Deep Secrets of Toxins”, Organized by the French Society of Toxinology on 2–3 December 2024
by Pascale Marchot, Ziad Fajloun, Évelyne Benoit and Sylvie Diochot
Toxins 2025, 17(2), 94; https://doi.org/10.3390/toxins17020094 - 17 Feb 2025
Viewed by 606
Abstract
The French Society of Toxinology (SFET) held its 30th Annual Meeting (RT30) on 2–3 December 2024 at Hôtel Le Saint Paul in Nice, France, on the beautiful French Riviera. It was the first time that the event was organized outside of Paris. The [...] Read more.
The French Society of Toxinology (SFET) held its 30th Annual Meeting (RT30) on 2–3 December 2024 at Hôtel Le Saint Paul in Nice, France, on the beautiful French Riviera. It was the first time that the event was organized outside of Paris. The meeting brought together 74 participants and focused on the main theme, “Unlocking the Deep Secrets of Toxins”, which delved into cutting-edge research in the field of animal venoms and toxins from animal, plant, fungal, algal, mold and bacterial sources. The event emphasized the dynamic and ever-evolving nature of toxins, often influenced by environmental factors, their interactions with molecular or cellular ligands, their mechanisms of action and their potential applications in therapy. These key topics were explored in depth during oral communications and poster sessions across three main thematic areas, each dedicated to a specific aspect of toxinology. A fourth, more general session provided an opportunity for participants to present recent work that fell outside the main themes but still contributed valuable insights to the broader field. This report presents the abstracts of seven of the invited lectures, fifteen of the selected lectures and sixteen of the posters, following the authors’ agreement to publish them. Additionally, the names of the “Best Oral Communication” and “Best Poster” awardees are highlighted, recognizing the outstanding contributions made by early-career researchers and their innovative work in toxinology. Full article
(This article belongs to the Special Issue Unlocking the Deep Secrets of Toxins)
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