Search Results (9,574)

This article presents a new combined post-processing concept to improve the quality of laser powder bed fusion (LPBF) of 17-4PH stainless steel (SS) cylindrical parts fabricated from N₂-atomised LaserForm 17-4PH (B) powder. The concept is based on consecutive heat treatment procedures and diamond burnishing (DB) processes. A two-stage study was conducted. The first stage was an LPBF process experiment. The following combination of LPBF parameter values was selected after optimisation: a laser power of $\mathrm{P}=150 \mathrm{W}$, laser scanning speed of v = 1200 mm/s, and layer thickness of $\mathrm{t}=40 \mathsf{\mu }\mathrm{m}$. In the second stage, this combination was used to evaluate the effects of two heat treatment procedures (HT1 and HT2) and two DB processes (using burnishing forces of 100 N and 300 N) on the tensile properties and surface integrity of LPBF 17-4PH SS cylindrical samples. The HT2 procedure, including annealing $({1200}^{\circ }$, $4 \mathrm{h})$, solution treatment (${1060}^{\circ }$, $1 \mathrm{h})$, cooling (${-70 }^{\circ }\mathrm{C},2 \mathrm{h}$), and ageing (${482}^{\circ }$, $4 \mathrm{h}$) led to yield limit, tensile strength, and Vickers hardness values of $\mathrm{Y}\mathrm{L}=1071 \mathrm{M}\mathrm{P}\mathrm{a}$, $\mathrm{T}\mathrm{S}=1410 \mathrm{M}\mathrm{P}\mathrm{a}$, and $523 \mathrm{H}\mathrm{V},$ respectively. The concept presented takes advantage of the combination of the transformation, precipitation and strain-hardening effects. The combined effect was most pronounced in the samples subjected to the HT2 procedure and subsequent DB (300 N), for which a retained austenite fraction of 6.93%, surface microhardness of ${563 \mathrm{H}\mathrm{V}}_{0.05}$ and the maximum values of the compressive axial and hoop RSs of $-1426.3 \mathrm{M}\mathrm{P}\mathrm{a}$ and $-1095.9 \mathrm{M}\mathrm{P}\mathrm{a}$, respectively, were measured. Full article

Accurate assessment of the A1 pulley is essential for the diagnosis and treatment of trigger finger, particularly in ultrasound-guided percutaneous release. Although high-resolution ultrasound is widely used to evaluate pulley morphology, the validity of sonographic measurements of A1 pulley length has not been clearly established against anatomical reference standard. This study evaluated the reliability and validity of ultrasound for measuring A1 pulley length and thickness in human cadavers and assessed the reproducibility of A2 pulley length. Twenty fingers from five fresh-frozen cadaveric hands were examined. Two blinded expert musculoskeletal sonographers independently performed ultrasound acquisition and measurements of A1 and A2 pulley length and A1 pulley thickness, while a third blinded observer obtained anatomical measurements after meticulous dissection using a digital caliper. Ultrasound systematically overestimated A1 pulley length compared with anatomical measurements and showed very poor reliability (ICC = 0.05) with wide limits of agreement. In contrast, A2 pulley length showed high interobserver reliability (ICC = 0.83) and relatively better agreement with anatomical values, whereas A1 pulley thickness showed moderate reproducibility (ICC = 0.61). Overall, A1 length measurements showed substantial variability and limited agreement, while A2 length and A1 thickness appeared more consistent within this experimental setting. These findings should be interpreted within the limitations of a cadaveric model. Full article

High-resolution thin-slice computed tomography (CT) images are often compressed into lower-quality thick-slice images for long-term storage, necessitating synthesis for medical diagnosis. In this paper, we propose a novel 3D adversarial diffusion model (3DAD) for high-fidelity synthesis of thin-slice CT from compressed thick-slice CT. 3DAD is composed of a generator and a discriminator for synthesizing denoised thin-slice images from random noise and source images and distinguishing between noised samples from real and denoised synthetic thin-slice images. Specific models were trained on two-slice to six-slice scenarios for abdominal data, using thick-slice CT compressed from real thin-slice CT as the source. 3DAD was evaluated at the time of HCC diagnosis, at the observation and patient levels, using real thin-slice and synthetic thin-slice CT, with DeLong’s test to compare the similarity of receiver operating characteristic (ROC) curves. We further evaluated 3DAD on real-world data with both thin and thick images, with the synthetic image quality assessed by radiologists and in radiomics feature analysis. Based on the external dataset with 548 samples, the achieved mean squared error (MSE), peak signal-to-noise ratio (PSNR), and structural similarity index measure (SSIM) values were 81.374, 29.478, and 0.916, respectively, for the five-slice scenarios at the portal venous phase. The Areas Under Curves (AUCs) achieved were 0.896 on synthetic thin-slice images compared with 0.889 on real thin-slice images at the observation level (p = 0.028) and 0.854 versus 0.846, correspondingly, at the patient level (p = 0.055). For evaluation on the real-world testing dataset after fine-tuning at the portal venous phase, the MSE, PSNR, and SSIM were 70.435, 30.243, and 0.94, respectively. Radiologist evaluation confirmed the high quality of the synthetic image, with no significant difference in the majority of cases across all five parameters, except for radiologist 2, in realistic and consistent situations, under which at least 41 of 43 synthetic images were assessed as equal to or above grade 3. Our 3DAD enabled the synthesis of thick-slice CT images into high-resolution thin-slice images, facilitating high-fidelity volume image application in HCC diagnosis. Full article

Objective: We aimed to assess whether modified OCT acquisition parameters improve GCIPL measurement reliability. Methods: Participants with multiple sclerosis (PwMS) and age- and sex-matched healthy controls (HC) underwent OCT (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) at baseline and after two and four weeks. At each visit, five macular scan protocols were acquired: standard (49 lines, high-speed [HS], automated real-time tracking [ART]: 9), high-ART (49 lines, HS, ART: 50), high-lines (97 lines, HS, ART: 9), high-resolution (49 lines, high-resolution [HR], ART: 9), and maximum (97 lines, HR, ART: 50). Reliability was assessed using intraclass correlation coefficients (ICC). Absolute test–retest reproducibility was quantified using the mean absolute difference (MAD). Results: Thirty-eight eyes from nine PwMS (mean age 34.1 ± 8.0 years, 44.4% female) and ten HC (31.7 ± 11.1 years, 50.0% female) were included. At baseline, mean GCIPL thickness ranged from 70.8 µm to 71.5 µm across protocols, demonstrating excellent inter-protocol agreement (ICC 0.99; 95% confidence interval [CI]: 0.98–0.99; p < 0.001) and only marginally higher values with increased ART. Test–retest reliability was excellent for all protocols, demonstrating marginally lower absolute measurement variability of high-ART and high-lines protocols (MAD 0.26–0.27; 95% CI: 0.21–0.32), while temporal agreement remained excellent and comparable across acquisition settings. Mean acquisition time ranged from 10.6 ± 1.6 s for the standard protocol to 231.9 ± 36.4 s for the maximum protocol. Conclusions: All OCT acquisition protocols demonstrated excellent inter-protocol and test–retest reliability for GCIPL measurements. The high-lines protocol provides the most favourable balance between measurement reliability and acquisition time, supporting its potential utility for longitudinal GCIPL monitoring. Full article

Cutaneous melanoma is an aggressive skin cancer. While laser therapy is established for non-melanoma skin cancers, its role in melanoma remains controversial and largely unsupported by robust clinical evidence. The gold standard for melanoma management remains surgical excision, as it allows for definitive histopathological diagnosis, Breslow thickness measurement, and surgical margin assessment, which are essential for accurate staging. This narrative review analyzed preclinical and clinical studies evaluating various laser modalities, including Nd:YAG, CO₂, pulsed dye, photodynamic therapy (PDT) and photothermal therapy (PTT), for efficacy, recurrence rates, and limitations in cutaneous melanoma management. Nd:YAG laser (1064 nm) showed potential for local control in thin stage I melanomas, reporting a low local recurrence rate of 0–0.7% and favorable 5-year survival in small, non-randomized cohorts. CO₂ laser (10,600 nm) provides effective palliation and local control for in-transit or unresectable metastases, but local recurrence is highly variable, reaching up to 46.7%. Photodynamic therapy showed variable efficacy, although Chlorin e6 achieved complete local regression in a small series of metastases. A critical limitation of laser therapy is the irreversible destruction of tissue, which precludes these vital assessments. Therefore, laser treatment should be cautiously reserved for cases where standard surgery is not feasible, acknowledging that it may interfere with the evaluation of curative outcomes and accurate staging. Laser therapy is a valuable minimally invasive adjunct for local control in selected patients who are poor surgical candidates or require palliative care. Routine use is restricted by the lack of randomized controlled trials. Future studies should prioritize combination strategies with systemic or immunotherapeutic approaches to enhance overall outcomes. Full article

Lithofacies characterization of organic-rich shales constitutes the essential foundation for sweet spot evaluation in lacustrine shale oil systems. This study targets the first member of the Upper Cretaceous Qingshankou Formation (K₂qn¹) in the southern Songliao Basin. Based on systematic core description of 908 m of core from eight cored wells, combined with 123 total organic carbon (TOC) measurements, 47 whole-rock X-ray diffraction (XRD) analyses, 29 major- and trace-element analyses, and six maceral identification datasets (≥500 organic particles counted per sample), together with conventional well log data from 75 wells (measured vitrinite reflectance $R_o$ = 0.34%–1.38%, mean = 0.94%), we establish an integrated lithofacies classification scheme incorporating the TOC as a classification parameter and develop a log-based lithofacies identification workflow. Eight lithofacies are recognized within K₂qn¹ across the study area, of which three are organic-rich. The high-TOC clay-rich mudstone-grade laminated shale deposited in a deep lake setting (LF-A; mean TOC = 3.18%, clay minerals ≥50%, formed under saline and strongly anoxic-euxinic conditions; mean paleosalinity = 8.06‰, V/(V + Ni) = 0.75–0.97) and the high-to-moderate-TOC felsic mudstone-grade laminated shale deposited in a semi-deep lake setting (LF-B; mean TOC = 2.18%, felsic minerals ≥50%, formed under brackish-to-saline anoxic conditions; mean paleosalinity = 5.10‰, V/(V + Ni) = 0.70–0.84) constitute the dominant organic-rich lithofacies. From Y1 to Y3, the cumulative thickness of organic-rich lithofacies expands from approximately 10 m to approximately 25 m. Areally, the mean TOC increases systematically from 1.65% in the southern delta-front zone to 2.74% in the northern deep lake center, reflecting an enrichment pattern governed primarily by paleoproductivity and modulated jointly by preservation conditions and terrigenous dilution. The log-based identification workflow, established by integrating a modified $\Delta$logR method with multiple linear regression, achieves a TOC prediction coefficient of determination of $R^2=0.86$ in the calibration well and lithofacies identification accuracies ranging from 64.6% to 94.0% in validation wells, with the highest performance observed in the delta-front facies zone. These results provide quantitative constraints for the genetic interpretation and log-based identification of organic-rich lacustrine shales. Full article

Ectomyelois ceratoniae (Zeller), the date moth, is a major pest of date palm (Phoenix dactylifera L.), responsible for severe post-harvest losses in arid and Mediterranean regions. The Sterile Insect Technique (SIT) is an environmentally friendly control method whose effectiveness depends on selecting irradiation doses that ensure sterility while preserving insect quality. This study evaluated the histopathological effects of ⁶⁰Co gamma irradiation on the digestive system of fifth-instar larvae of E. ceratoniae. Larvae were exposed to doses of 0 (control), 250, 300, 350, and 450 Gy, and the mesenteron, proctodeum, and Malpighian tubules were analyzed using Mallory’s trichrome staining. Quantitative measurements included epithelial thickness, intestinal stem cell density, Malpighian tubule diameter, and a histological integrity index. Gamma irradiation induced pronounced dose-dependent alterations. These included thinning and disorganization of the intestinal epithelium, a marked reduction in stem cell density, swelling of Malpighian tubules, and a progressive loss of tissue integrity. Severe degeneration and functional collapse of digestive tissues were observed at doses ≥ 350 Gy. The results indicate that 300–350 Gy represents a critical irradiation range inducing irreversible digestive damage compatible with effective sterilization. These findings provide histopathological reference criteria for optimizing dose selection and quality control in SIT programs targeting E. ceratoniae. Full article

Background/Objectives: Teledermoscopy may improve melanoma triage by accelerating specialist review and compressing the time to definitive treatment, but its clinical relevance depends on whether faster access is accompanied by detection at a less advanced stage. This study compared teledermoscopy-assisted and conventional referral pathways for cutaneous melanoma as a pathway-level service evaluation. Methods: In this single-center observational cohort, 87 patients with histologically confirmed primary cutaneous melanoma were analyzed, including 43 managed through teledermoscopy-assisted referral and 44 through a conventional pathway. Primary outcomes were time from referral to dermatology consultation, biopsy, and definitive excision. Secondary outcomes included Breslow thickness, mitotic rate, ulceration, stage distribution, early-stage disease, and selected pathway-quality indicators. Results: Teledermoscopy-assisted referral was associated with shorter median times to consultation (9.0 vs. 18.7 days), biopsy (16.6 vs. 30.3 days), and excision (26.9 vs. 43.2 days), all p < 0.001. Patients in the teledermoscopy group had lower Breslow thickness (0.7 vs. 1.5 mm, p < 0.001), lower mitotic rate (1.2 vs. 2.9 mitoses/mm², p < 0.001), a higher proportion of stage 0/I melanoma (79.1% vs. 40.9%; risk ratio 1.93, 95% CI 1.31–2.85), and fewer lesions with Breslow > 2.0 mm (9.3% vs. 36.4%; risk ratio 0.26, 95% CI 0.09–0.70). Conclusions: In this non-randomized cohort, teledermoscopy-assisted referral was associated with faster melanoma care and a more favorable stage profile at excision. Because pathway assignment was not randomized and lesion-level referral urgency was incompletely measured, these findings should be interpreted as associations that support further prospective evaluation rather than as proof of causal stage migration. Full article

This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and PN providing hydration and skin support, and niacinamide offering anti-inflammatory and antioxidant properties. A prospective, open-label clinical investigation was conducted on 42 female subjects (mean age 45 ± 1 years, Fitzpatrick skin phototypes II-V) to assess skin elasticity, hydration, and mild skin depression correction following cheek area injections. Efficacy was measured using the Global Aesthetic Improvement Scale (GAIS), Antera 3D^® (texture), Cutometer^® (elasticity/firmness), Corneometer^® (hydration), and Dermascan^® (density/thickness) devices at baseline (D0), week 2 (W2/D14), and week 6 (W6/D42). GAIS values showed significant overall facial improvement (p < 0.001) by both investigators and subjects, where 100% of subjects rated their appearance as improved immediately post-injection (D0), with sustained improvements at D42. Objective measurements revealed significant improvements in skin texture (reduced roughness), elasticity, firmness, hydration (p < 0.001), density, and thickness, demonstrating the combined benefits of the HA, PN, and niacinamide blend. Injection site reactions, primarily mild and transient, were reported immediately post-injection. Investigators and subjects reported high satisfaction with the product’s ease of use and aesthetic outcomes. Globally, HYDRAGEL A2, leveraging the established benefits of HA, PN, and niacinamide, was well-tolerated and effectively enhanced facial skin quality, demonstrating significant and sustained improvements in monitored skin parameters. The study concludes that this combination of ingredients, formulated in HYDRAGEL A2, provides a well-tolerated approach associated with improvements in skin quality. Full article

Due to their unique topography, deep open-pit coal mines are prone to temperature inversions, which, in turn, exacerbate dust pollution. To characterize this phenomenon, we combined field measurements with FLUENT-based numerical simulations to analyze how inversion layer properties and dust transport patterns respond to varying conditions. The results show that the temperature contrast between the pit walls is positively correlated with the inversion layer’s temperature difference, thickness, and strength. In contrast, ambient wind speed is negatively correlated with the layer’s temperature difference and strength, yet positively correlated with its thickness. Surface temperature has no significant effect on the inversion layer’s temperature difference or thickness and exhibits only a weak correlation with its strength. Furthermore, higher wall temperature contrasts lead to increased dust concentration, whereas stronger winds promote dispersion and lower concentrations. These findings confirm that temperature inversion intensifies pollution, with stronger inversions causing more severe contamination. Therefore, mitigating the formation of inversion layers is crucial for effective dust control in deep pits. Unlike previous phenomenological observations, this study provides novel quantitative data on the thermal-aerodynamic coupling within deep open pits. Specifically, it establishes exact mathematical correlations between discrete rock wall temperature differentials and inversion layer thickness, providing critical thresholds for predicting severe dust retention. Full article

To investigate the effects of planting density and chemical regulation measures, as well as their interactions, on the plant morphological characteristics, stem mechanical properties, leaf anatomical structure, dry matter accumulation and allocation, and yield and its components of grain maize in the Hexi Oasis irrigation area, a field experiment was conducted from 2024 to 2025. Planting density was set as the main factor, with five density levels: 82,500 plants·ha⁻¹ (M1), 97,500 plants·ha⁻¹ (M2), 112,500 plants·ha⁻¹ (M3), 127,500 plants·ha⁻¹ (M4) and 142,500 plants·ha⁻¹ (M5). Chemical regulation measures were set as the secondary factor, consisting of two treatments: spraying 30% aminoethyl hexanoate·ethephon at the 10-leaf stage (T1) and spraying an equal amount of water as the control (T2). The results revealed that, as planting density increases, the maize plant height, ear height and stem breakage rate rise continuously, whilst stem diameter, stem breaking resistance, rind puncture strength, leaf thickness and epidermal tissue thickness showed a downward trend. The leaf area index, ear length, kernel number per ear, kernel weight and yield all exhibited a trend of first increasing and then decreasing, reaching their peak at the M3 planting density. Compared with conventional planting patterns, spraying chemical regulators significantly reduced plant height by 10.66~13.99% and ear height by 16.12~19.57%, increased stem diameter by 2.12~13.79%, and enhanced stem breaking resistance by 7.71~23.11% and rind puncture strength by 5.17~12.65% at 30 days after silking. Additionally, it delayed leaf senescence, increased the leaf area index by 4.37~10.03% during the filling stage, and increased yield by 1.99~4.06%. The synergistic effect of moderately increasing planting density combined with chemical regulation can effectively coordinate the ‘population–individual’ contradiction in maize, reduce plant height and ear height and increase stem diameter and rind puncture strength, while maintaining a higher leaf area index after the silking stage and promoting dry matter translocation to grains, thereby achieving a synergy between lodging resistance and high yield. Among them, a planting density of 112,500 plants·ha⁻¹ combined with spraying chemical regulators yielded the highest maize yield and harvest index, reaching 20.28~20.48 t·ha⁻¹ and 0.52~0.53, respectively. Compared with other treatments, the increases ranged from 2.54~47.51% for yield and from 1.92~36.84% for the harvest index. Meanwhile, this treatment exhibited superior stem mechanical properties and a lower stem breakage rate. Taking into account factors such as lodging resistance, yield, dry matter accumulation and allocation, it has been determined that a planting density of 112,500 plants·ha⁻¹ combined with spraying 30% aminoethyl hexanoate·ethephon at the 10-leaf stage is an effective strategy for achieving both lodging resistance and high yield in grain maize in the Hexi Oasis irrigation area. Full article

Background: Accurate tibial resection is important for component alignment and implant longevity in total knee arthroplasty (TKA). Despite the utilization of standardized instrumentation, discrepancies between predicted and actual resection depth persist. In the current study, the correlation between stylus-derived measurements and actual tibial resection thickness is analyzed. Methods: A total of 109 patients undergoing primary TKA using the Legion system (Smith & Nephew, Memphis, TN, USA) were included. The intraoperative resection depth was measured with a stylus at the selected tibial reference point and compared with the caliper-measured osteochondral thickness of the resected tibial fragment at the same location. Correlations were assessed using Spearman’s rank correlation, while agreement was evaluated using Bland–Altman analysis. Results: The mean stylus-indicated resection depth was 4.24 ± 2.15 mm, whereas the mean caliper-measured osteochondral thickness at the same marked reference point was 5.75 ± 2.30 mm. After adjustment for the 1.37 mm saw blade kerf, the mean osteochondral resection thickness was 7.12 ± 2.30 mm. The mean discrepancy between planned and kerf-adjusted osteochondral resection was −2.85 (SD = 1.99 mm; 95% CI: −3.22 to −2.47 mm) indicating a tendency toward over-resection. The correlation between stylus-indicated depth and actual osteochondral resection thickness was moderate (ρ = 0.540, p < 0.001). Bland–Altman analysis showed wide 95% limits of agreement from −6.75 to 1.05 mm. Conclusions: Stylus-based predictions of tibial resection depth show limited accuracy. Stylus-based measurements should be interpreted with caution and complemented by intraoperative verification. Full article

Accurate prediction of Rate of Penetration (ROP) in carbonate formations remains constrained by the arbitrary selection of geomechanical input parameters in empirical drilling models. This study presents the first systematic field-based evaluation of sixteen geomechanical properties—grouped into three categories: strength parameters (uniaxial compressive strength (UCS), confined compressive strength (CCS), shear strength, thick-walled cylinder strength (TWC), friction angle, and cohesion), elastic moduli (Young’s modulus, shear modulus, bulk modulus, bulk compressibility, dynamic combined modulus (DCM), Poisson’s ratio, brittleness index), and in situ stress parameters (overburden pressure, minimum, and maximum horizontal stresses)—to identify optimal predictors for ROP modeling across PDC bit sizes of 12.25″ and 8.5″. Continuous wireline log data from two vertical carbonate wells in the Middle East (Well A: 1000–3370 m; Well B: 1945 to 3128 m; total intervals of 2370 m and 1183 m, respectively) penetrating formations comprising limestone, dolomite, sandstone, shale, anhydrite, and marly limestone were used. All sixteen geomechanical properties were computed using Interactive Petrophysics (IP) software with lithology-specific empirical correlations and validated against laboratory core measurements (R² = 0.79–0.95). Pearson and Spearman correlation analyses quantified parameter–ROP relationships, and the Al-Abduljabbar empirical model, recalibrated via multiple nonlinear regression, served as the evaluation framework. DCM consistently exhibited the strongest negative correlation with ROP across both bit sizes and achieved the highest model accuracy (R² = 0.54, AAPE = 25.33%), significantly outperforming the Bourgoyne and Young model (R² = 0.26, AAPE = 36.55%). A statistically validated scale-dependent effect was identified: Fisher’s Z-transformation tests confirmed that the correlation reversal between CCS and UCS across bit sizes is statistically significant (CCS: Z = −16.84, p < 0.001; UCS: Z = −6.75, p < 0.001), establishing CCS as the superior predictor at 12.25″ and UCS as the superior predictor at 8.5″—a finding not previously reported in the ROP literature. This reversal is attributed to the larger contact area of the 12.25″ bit, which promotes confinement-dominated rock failure better described by CCS, whereas the smaller bit produces localized stress concentration better represented by UCS. These results establish that (1) optimal geomechanical input selection is bit-size dependent, (2) nonlinear modeling outperforms linear frameworks for strength–ROP relationships, and (3) parameter relevance outweighs coefficient tuning in model robustness. DCM is recommended as the most operationally practical universal input, requiring only conventional compressional sonic and density logs. This study provides a systematic framework for geomechanical parameter selection with direct implications for drilling optimization in heterogeneous carbonate reservoirs. Full article

Wood-based panels are increasingly used in exterior applications; however, comprehensive evaluations of their durability under standardized aging conditions remain limited. This study evaluates the dimensional stability and mechanical performance of three industrial panels designed for exterior use: a three-layer particleboard (PB1) and a single-layer particleboard (PB2), both bonded with phenol–formaldehyde adhesive, and a medium-density fibreboard (MDF), bonded with polymeric methylene diphenyl diisocyanate through accelerated aging. The panels were subjected to six accelerated aging cycles according to the ASTM D1037-12 (2020) standard. Equilibrium moisture content, residual thickness swelling (Residual-TS), bending modulus of rupture (MOR), modulus of elasticity (MOE) in both parallel and perpendicular directions, and internal bond (IB) strength were measured under aged and non-aged conditions. PB2 demonstrated superior dimensional stability (Residual-TS: 0.49%) and strong mechanical retention (MOR: 67%, MOE: 56%–64%, IB: 75%). PB1 showed intermediate dimensional stability and mechanical retention (Residual-TS: 1.58%; MOR: 66%–74%, MOE: 56%–58%, IB: 71%), while MDF exhibited higher sensitivity to aging, with excessive Residual-TS (5.43%) and lower IB strength retention (30%). Specimen orientation did not affect dimensional stability but did influence the bending properties of the particleboard after aging, specifically MOR in PB2 and MOE in PB1. The results demonstrate that PB2 offers superior performance for demanding exterior applications, while PB1 and MDF are suitable for semi-protected uses. All panels were tested in an unfinished state, although surface coatings in actual applications may further enhance the resistance to aging. Full article

Background: Osteoinduction and bone regeneration are fundamental biological mechanisms enabling osseointegration and long-term durability of endosseous dental implants. In clinical practice, poor bone conditions, aesthetic demands, and peri-implant soft tissue problems commonly need the utilization of regenerative techniques targeted at optimizing both hard and soft tissue results. The purpose of this narrative review was to examine osteo-inductive and regenerative strategies currently employed in implant dentistry, with particular emphasis on the mechanobiological integration of hard–soft tissue regeneration and its implications for peri-implant tissue stability, osseointegration, and clinical predictability. Methods: A narrative literature review was done using PubMed and Scopus databases. Based on predetermined inclusion and exclusion criteria, studies published in English during the previous five years were reviewed. The core narrative analysis comprised a selection of physiologically relevant research that addressed osteo-inductive techniques, bone regeneration, osseointegration, and peri-implant soft tissue outcomes, as well as clinical studies, randomized controlled trials, systematic reviews, and narrative reviews. A narrative synthesis was carried out because of methodological variability. Special emphasis was placed on evidence addressing the biological and clinical interaction between hard- and soft-tissue regenerative strategies, reflecting the specific conceptual focus of the review. Results: The evidence presented suggests that implant surface biofunctionalization, biologically active grafting materials, guided bone regeneration, and supplementary biological treatments may have a favorable impact on implant stability and peri-implant bone healing. Several investigations also underlined the biological dependency between peri-implant bone regeneration and soft tissue architecture, stressing the significance of soft tissue thickness, keratinized mucosa, and emergence profile stability. Even in inflammatory environments, bioactive titanium surface changes showed osteogenic potential, indicating a supporting function in early osseointegration. Conclusions: By promoting osseointegration and improving peri-implant tissue outcomes, osteo-inductive and regenerative techniques are essential to modern implant dentistry; however, their greatest potential may lie in integrated hard–soft tissue regenerative approaches aimed at improving long-term clinical predictability. To further understand the clinical efficacy of combination hard–soft tissue regeneration methods, future well-designed clinical trials with standardized outcome measures are needed. Future research should further clarify the mechanobiological principles underlying these integrated regenerative approaches. Full article