Search Results (500)

Background/Objectives: Recurrent oral ulceration (ROU) is the most prevalent disorder of the oral mucosa, affecting approximately 20% of the global population. Current therapies are limited by adverse effects and high recurrence rates. Ai-Fen, enriched in the anti-inflammatory monoterpenoid L-borneol (54.3% w/w), exhibits therapeutic potential but suffers from poor aqueous solubility and low bioavailability. This study aimed to improve the physicochemical properties and in vivo efficacy of Ai-Fen through the preparation of solid dispersions. Methods: Ai-Fen solid dispersions (AF-SD) were prepared by a melt-fusion method using polyethylene glycol 6000 (PEG 6000) as the carrier. An L₉(3³) orthogonal design was employed to optimize three critical parameters: drug-to-carrier ratio, melting temperature, and melting duration. The resulting dispersions were systematically characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). A chemically induced ROU model in rats (n = 8 per group) was established to evaluate the effects of AF-SD on ulcer area, serum inflammatory cytokines (TNF-α, IL-6), vascular endothelial growth factor (VEGF) levels, and histopathological outcomes. Results: The optimal formulation was obtained at a drug-to-carrier ratio of 1:2, a melting temperature of 70 °C, and a melting time of 5 min. Under these conditions, L-borneol release increased 2.5-fold. DSC and PXRD confirmed complete conversion of Ai-Fen to an amorphous state, while FTIR revealed a 13 cm⁻¹ red shift in the O-H stretching band, indicating hydrogen-bond formation. In vivo, AF-SD reduced ulcer area by 60.7% (p < 0.001) and achieved a healing rate of 74.16%. Serum TNF-α and IL-6 decreased by 55.5% and 49.6%, respectively (both p < 0.001), whereas VEGF increased by 89.6% (p < 0.001). Histological analysis confirmed marked reduction in inflammatory infiltration, accelerated re-epithelialization (score 2.50), and a 5.9-fold increase in neovascularization. Conclusions: AF-SD markedly enhanced the bioavailability of Ai-Fen through amorphization and accelerated ROU healing, likely via dual mechanisms involving suppression of nuclear factor kappa-B (NF-κB)-mediated inflammation and promotion of angiogenesis. This formulation strategy provides a promising approach for modernizing traditional herbal medicines. Full article

Auxetic metamaterials, characterised by a negative Poisson’s ratio, offer excellent energy absorption but often present limited compressive strength due to their strut-based architectures. Selective laser sintering (SLS) enables the precise fabrication of these structures, yet enhancing their mechanical performance remains challenging. This research investigates the influence of nodal spheres on re-entrant dodecahedral unit cells produced in PA12, varying node-to-strut diameter ratios (1:1, 2:1, and 3:1). Compression tests reveal significant increases in stiffness and compressive strength, reaching up to 88.70% for the 3:1 ratio. When normalised by relative density, the 2:1 configuration proves most effective, achieving a 35.33% increase in specific strength and a 19.58% improvement in specific energy absorption. The deformation behaviour indicates a mixed bending–stretching mechanism, with geometry exerting a stronger influence than the base material. Although larger nodal spheres enhance absolute strength, they also increase mass and relative density, which may limit their suitability for weight-sensitive applications. Overall, these findings highlight nodal reinforcement as a promising strategy to enhance the mechanical efficiency of auxetic metamaterials while maintaining their auxetic response. These improvements support applications in aerospace, automotive engineering, personal protection systems, lightweight structural panels, and energy-absorbing components. Full article

Auxetic textiles, characterized by a negative Poisson’s ratio, offer considerable promise for innovative applications across multiple fields. In our earlier work, Miura-ori-inspired auxetic fabrics with three different initial dihedral fold angles—30°, 45°, and 60°—were successfully fabricated via jacquard weaving. Their fundamental auxetic behaviors were evaluated, showing deformation characteristics consistent with those in their geometric models. This study further investigates the mechanical properties of Miura-ori-based auxetic woven fabrics. Tensile testing, air permeability measurement, compression performance assessment, and repeated-loading cyclic rope-stretching tests were performed on the three fabric variants. The results show that the fabrics exhibit excellent air permeability, which increases with the proportion of the folded areas; the highest air permeability was observed at Miura-30°. Moreover, Miura-60° exhibited superior compression resistance. The fabrics also demonstrated outstanding structural stability under cyclic tensile loading, exhibiting optimal elastic recovery at the 30° configuration. Collectively, these findings provide a solid theoretical basis for future applications of Miura-ori auxetic woven fabrics. Full article

Blow spinning is a low-cost and versatile method that permits the large-scale production of fibrous membranes. However, polysaccharides that show numerous merits such as biocompatibility and biodegradability often have a low spinnability due to their high chain rigidity and low ability to form sufficient entanglements. Here, we report the fabrication of polysaccharide micro-fibrous membranes from sodium alginate/polyethylene oxide solutions formulated in solvent mixtures of water and ethanol. The shear and extensional rheological responses of the solutions are characterized, and parameters including specific shear viscosity, reptation time, extensional relaxation time, and maximum stretch ratio are correlated with the concentrations of polymer, polyethylene oxide, and ethanol. It is found that flexible polyethylene oxide and poorer solvent ethanol can synergistically delay the chain relaxation during stretch and increase the stretchability of the solutions. A processability map of the solutions for blow spinning is constructed, enabling the fabrication of fibrous membranes with a fiber diameter of ~1 μm, tensile strength of 4.89 MPa, elongation at break of 15.24%, and Young’s modulus of 45.43 MPa. This study presents a new strategy to fabricate sodium alginate-based membranes, which should provide insights into the design of other polysaccharide membranes with specific functions and applications. Full article

Drug delivery from cylindrical tablets of arbitrary dimensions is discussed here, using the analytical solution of diffusion equation. Utilizing dimensionless quantities, we show that the release profiles are determined by a unique parameter, represented by the aspect ratio of the cylindrical formulation. Fractional release curves are presented for different values of the aspect ratio, covering a range of many orders of magnitude. The corresponding release profiles lie in between the two opposite limits of release from thin slabs and two-dimensional radial release, pertinent to the cases of thin and long cylinders, respectively. In a quest for a part of the delivery process closer to a zero-order release, the release rate is calculated, which is found to exhibit the typical behavior of purely diffusional release systems. Two simple fitting formulae, containing two parameters each, are considered to approximate the infinite series of the exact solution: The stretched exponential (Weibull) function and a recently suggested expression interpolating between the correct time dependencies at the initial and final stages of the process. The latter provides a better fitting in all cases. The variation of the fitting parameters with the aspect ratio of the device is presented for both fitting functions. We also calculate the characteristic release time, which is found to correspond to an amount of fractional release between 64% and around 68% depending on the cylindrical aspect ratio. We discuss how the last quantities can be used to estimate the drug diffusion coefficient from experimental release profiles and apply these ideas to published drug delivery data. Full article

This study investigates the thermal characteristics of two hybrid nanofluids, single-walled carbon nanotubes with titanium dioxide ($SWCNT-Ti{O}_2$) and multi-walled carbon nanotubes with copper ($MWCNT-Cu$), as they flow over an inclined, porous, and longitudinally stretched cylindrical surface with kerosene as the base fluid. The model takes into consideration all of the consequences of magnetohydrodynamic (MHD) effects, thermal radiation, and Arrhenius-like energy of activation. The outcomes of this investigation hold practical significance for energy storage systems, nuclear reactor heat exchangers, electronic cooling devices, biomedical hyperthermia treatments, oil and gas transport processes, and aerospace thermal protection technologies. The proposed hybrid ANN–numerical framework provides an effective strategy for optimizing the thermal performance of hybrid nanofluids in advanced thermal management and energy systems. A set of coupled ordinary differential equations is created by applying similarity transformations to the governing nonlinear partial differential equations that reflect conservation of mass, momentum, energy, and species concentration. The boundary value problem solver bvp4c, which is based in MATLAB (R2020b), is used to solve these equations numerically. The findings demonstrate that, in comparison to the $MWCNT-Cu/kerosene$ nanofluid, the $SWCNT-Ti{O}_2$/kerosene hybrid nanofluid improves the heat transfer rate (Nusselt number) by up to $23.6\%$. When a magnetic field is applied, velocity magnitudes are reduced by almost $15\%$, and the temperature field is enhanced by around $12\%$ when thermal radiation is applied. The impact of important dimensionless variables, such as the cylindrical surface’s inclination angle, the medium’s porosity, the magnetic field’s strength, the thermal radiation parameter, the curvature ratio, the activation energy, and the volume fraction of nanoparticles, is investigated in detail using a parametric study. According to the comparison findings, at the same flow and thermal boundary conditions, the $SWCNT-Ti{O}_2$/kerosene hybrid nanofluid performs better thermally than its $MWCNT-Cu$/kerosene counterpart. These results offer important new information for maximizing heat transfer in engineering systems with hybrid nanofluids and inclined porous geometries under intricate physical conditions. With its high degree of agreement with numerical results, the ANN model provides a computationally effective stand-in for real-time thermal system optimization. Full article

This study investigated the effects of lightweight wearable resistance on the kinetics and kinematics of squat jumps (SJ) and countermovement jumps (CMJ) with 2%, 4%, and 6% body mass (BM). Twenty male athletes (age: 18.05 ± 0.6 years; weight: 76.4 ± 7.6 kg; height: 182.4 ± 5 cm) were assessed on a force plate. Key variables included jump height (JH), concentric (ConT) and eccentric (EccT) phase durations, concentric impulse (CI), mean force (CMF), mean velocity (CMV), mean power (CMP), and relative metrics. Elastic utilization ratios (EUR) were calculated to quantify stretch-shortening cycle enhancement. Load led to decrements in both jumps but with varying sensitivity. With 2% BM the CMJ significantly reduced JH (−8.6%), EccT (−7%), CMV (−4.1%), rCI (−4.1%), rPP (−4.4%), and velocity at PP (−4.8%), whereas variables in the SJ were non-significant until 4–6% BM. EURs observed the greatest differences with 2% BM with JH, CMV, rCMP, and VPP all significantly decreasing (p < 0.05). The varying sensitivity to load across variables observed in the two jumps supports the hypothesis that SJ and CMJ offer distinct diagnostic insights due to varying MTU contraction dynamics and neural factors. This has implications for WR use in training. Further, absolute metrics showed limited load sensitivity. However, when accounting for body mass, relative metrics revealed substantial declines. This indicates absolute values can misrepresent the effects of WR loading. Full article

As a zero-carbon fuel, ammonia holds significant potential for achieving the “dual carbon” strategic goals. However, its extremely low laminar burning velocity (LBV) limits its direct application in combustion systems. This work systematically reviews the research progress on the LBV of ammonia flames, focusing on three key aspects: measurement methods, effects of combustion conditions, and reaction kinetic models. In terms of measurement methods, the principles, applicability, and limitations of the spherical outwardly propagating flame method, Bunsen-burner method, counter-flow flame method, and heat flux method are discussed in detail. It is pointed out that the heat flux method and counter-flow flame method are more suitable for the accurate measurement of ammonia flame LBV due to their low stretch rate and high stability. Regarding the effects of combustion conditions, the LBV characteristics of pure ammonia flames under ambient temperature and pressure are summarized. The influence patterns of three factors on LBV are analyzed systematically: blending high-reactivity fuels (e.g., hydrogen and methane), oxygen-enriched conditions, and variations in temperature and pressure. This analysis reveals effective approaches to improve ammonia combustion performance. Furthermore, the promoting effect of high-reactivity fuel blending on liquid ammonia combustion was also summarized. For reaction kinetic models, various chemical reaction mechanisms applicable to pure ammonia and ammonia-blended fuels (ammonia/hydrogen, ammonia/methane, etc.) are sorted out. The performance and discrepancies of each model in predicting LBV are evaluated. It is noted that current models still have significant uncertainties under specific conditions, such as high pressure and moderate blending ratios. This review aims to provide theoretical references and data support for the fundamental research and engineering application of ammonia combustion, promoting the development and application of ammonia as a clean fuel. Full article

In serpentinite-related green nephrite, light-colored nephrite commonly occurs as veins or interlayers at nearly every nephrite locality. However, its characteristics have been poorly understood. In this study, samples containing both green and light-colored nephrites from the Ospa deposit in East Sayan, Russia, were selected for integrated petrographic and geochemical analyses. Petrographic observations identified three domains transitioning from green to light-colored nephrite: the green domain, the transition band, and the light-colored domain. Although both the green domain and the transition band consist of oriented tremolite fibers, the fiber orientations differ between these two domains. In contrast, the light-colored domain typically exhibits non-oriented fibers and fine grains with flow textures. Geochemical data reveal a decrease in Cr and Ni contents from the green domain to the light-colored domain, while Fe and Mn contents remain relatively stable. Additionally, significant enrichments of Hf and Zr were observed in the light-colored domain. These observations suggest that the light-colored domain precipitated from a later-stage fluid distinct from the fluid sources responsible for the green nephrite, with the transition band resulting from the late fluid reacting with syn-deformational green nephrite. Thus, a model for light-colored nephrite formation can be simplified as a process in which a late fluid, low in Cr and Ni, precipitates predominantly within the stretched structures of green nephrite. UV-Vis spectroscopy on the studied samples, combined with a comparative analysis of chromogenic complexes in nephrites of various colors, further indicates that the green hue of the specific grayish-green in light-colored nephrite is dominantly controlled by Cr, whereas its grayish hue is modified by the ratio of (Fe + Mn) to Cr. These findings elucidate the formation sequence and genetic mechanisms behind light-colored nephrite, offering a thorough comprehension of nephritization in serpentinite-related deposits. Full article

Skin meshing facilitates the greater expansion of donor skin through patterned slits and is widely used for treating extensive burn injuries. However, the actual expansion often falls below manufacturers’ claims. Previous computational analyses using the isotropic Yeoh model have shown that Langer’s line orientation and slit direction significantly affect induced stress and meshing ratios, yet the use of nonlinear anisotropic models that represent collagen fiber alignment corresponding to Langer’s lines remains unexplored. This study employs a nonlinear anisotropic Gasser–Ogden–Holzapfel (GOH) model with slit orientations of 0°, 45°, and 90°, consistent with geometries reported in the literature, to quantify induced stress in skin meshing by incorporating collagen fibers within the dermis layer. The GOH parameters were calibrated to human back skin data uniaxially stretched parallel and perpendicular to Langer’s lines using Levenberg–Marquardt optimization in the GIBBON toolbox (MATLAB R2023a) coupled with FEBio v4.0, achieving a standard deviation of 3% relative to experimental data. The GOH model predicted the highest induced stress at 100% strain for the 45° slit parallel to Langer’s lines and the lowest for the 90° slit perpendicular, exceeding 40 MPa due to absence of damage and rupture modeling but accurately representing anisotropic mesh behavior. Full article

Chronic heart failure (CHF) carries high morbidity and mortality. Circulating biomarkers of myocardial stretch, injury, and remodelling aids diagnosis and prognosis, but utility varies, especially in HFpEF, where natriuretic peptide (NP) values may be lower or normal in obesity. We systematically searched PubMed, Scopus, and Web of Science (2010–2025) for primary adult chronic-HF studies evaluating blood-based biomarkers: NPs, high-sensitivity troponins (hs-cTn), galectin-3, soluble ST2 (sST2), and microRNAs. Secondary sources (reviews/meta-analyses/guidelines) informed context only. Acute-HF studies were not pooled with chronic-HF analyses. Where appropriate, log hazard ratios were meta-analysed with random effects models. Twenty-nine studies met criteria. NT-proBNP remained the diagnostic/prognostic reference; across five prognostic cohorts, the pooled HR was 1.68 (95% CI 1.54–1.82; I² ≈ 55%). hs-cTn consistently improved risk stratification. Galectin-3 and sST2 were associated with adverse outcomes but typically provided modest incremental value beyond NPs/hs-cTn; galectin-3 is influenced by renal function, and sST2 is commonly interpreted around ~28–35 ng/mL. MicroRNAs (e.g., miR-21, miR-210-3p, miR-22-3p) showed promising yet heterogeneous signals across platforms and preanalytical workflows; therefore, findings were synthesised narratively without pooling. NT-proBNP and hs-cTn form the evidence-based backbone for biomarker-guided assessment in chronic HF. Galectin-3 and sST2 add adjunct prognostic information, while microRNAs remain investigational, pending standardised methods and external validation. Overall, evidence supports a multimarker, phenotype-tailored approach, with core NPs + hs-cTn and selective adjunct use of sST2/galectin-3 in context (HFrEF vs. HFpEF, obesity, renal function) to refine risk stratification and guide clinical decision-making. Full article

We present a combined experimental and modeling study of premixed atmospheric-pressure tetralin flames. Chemical speciation in near-stoichiometric (φ = 0.8–1.0) tetralin/O₂/Ar flames was characterized by probe-sampling molecular-beam mass spectrometry (MBMS) with soft ionization (12.3–18 eV). Total ionization cross-sections (TICSs) for heavy intermediates were computed ab initio to enable quantitative MBMS processing. Laminar burning velocities (LBVs) of tetralin/air flames were measured in a range of equivalence ratios (φ = 0.75–1.5) on a nozzle burner via the stretch-corrected total area method. This is the first reported LBV data for tetralin/air flames (maximum LBV was 47.3 ± 2 cm/s at φ = 1.1). The experimental mole fraction profiles and LBVs were interpreted using three detailed mechanisms. None of the mechanisms were able to correctly describe the LBV profile, and a number of discrepancies were observed in the mole fraction profiles. Reaction network and sensitivity analyses were performed to identify specific sub-mechanisms requiring refinement. In particular, the subchemistry of naphthalene and indene strongly affects the accuracy of model predictions, whereas the flame speciation data indicate large uncertainties in the simulated concentrations of these species. Full article

In recent years, lab-grown diamonds have become more popular in both domestic and international markets for their rich color palette. Research on yellow lab-grown diamonds has primarily focused on spectroscopic and defect characteristics currently, while the study has largely focused on nitrogen content and related color-causing mechanisms, such as NV series defects. However, the relationship between nitrogen content and defects and color is limited. In this study, eight lab-grown diamonds with varying yellow shades were selected as samples to be studied by photoluminescence spectra, infrared spectra, Raman spectra, and colorimetry testing. Based on the colorimetric parameters L*, a*, and b*, the standard formula for the yellowness index, the intensities of the NV⁰ and NV⁻ peaks in the photoluminescence spectra and the absorptivity in the infrared spectra, the hue angle h, the yellowness index YI E313, the concentration ratio of NV⁻ defect in NV color centers R, and the nitrogen content N_C were calculated. Results indicate that characteristic peaks of NV series defects as a specific photoluminescence signature, notably the absence of [Si-V]⁻ defect, demonstrate that the samples are high-temperature, high-pressure diamonds derived from graphite that underwent post-growth irradiation. The specific infrared signature indicates that the type of samples is type Ib, attributed to isolated nitrogen (C aggregate). The intrinsic peak of diamond is detected in Raman spectra, with symmetric stretching vibrations of C and N and the ‘D’ peak of graphite is detected as well. Meanwhile, the yellowness index shows a negative correlation with hue angle, a positive correlation with concentration ratio, and a positive linear correlation with nitrogen content, the equation $y=0.17x+124.40$. The yellowness index is divided into three levels: 70–80, 80–90, and 90–100. The yellow hue of samples is light between 70–80, intense between 80–90, and deep between 90–100. Full article

Chlamydomonas reinhardtii serves as a sustainable and high-quality protein source. In this study, Chlamydomonas reinhardtii powder (CRP) was used to replace wheat flour at proportions of 0% (C0), 2.5% (C2.5), 5% (C5), 7.5% (C7.5), and 10% (C10) for the production of soda crackers and cookies. The study compared the pasting and farinographic properties of wheat flour with that of CRP and found that C2.5 demonstrated optimal performance in terms of stretching energy and stretching ratio. Regarding the expansion ratios of soda crackers and cookies, C2.5 achieved the highest value compared to C5, C7.5, C10, and had no significant difference compared to C0. The incorporation of CRP resulted in an increase in the L* value and whiteness index (WI), a reduction in the chromaticity value (C*), and a noticeable shift towards a greener hue in the overall color. This study offers a thorough exploration and establishes a robust theoretical foundation for baked foods enriched with CRP. Full article

Background/Objectives: Ultra-processed food consumption has been shown to be linked with clinical cardiovascular disease. This study aims to examine the associations of ultra-processed food consumption with biomarkers for subclinical-level myocardial damage [high-sensitivity cardiac troponin I and T (hs-cTnI and hs-cTnT)] and myocardial stretch (NT-proBNP) in U.S. adults. Methods: We used data from 6615 U.S. adults aged ≥20 years without prevalent cardiovascular disease from the National Health and Nutrition Examination Survey 2001–2004. We identified ultra-processed food by applying the Nova classification to dietary recall data, and we divided participants into quartiles based on their consumption, expressed as a proportion of total daily energy (%kcal) and gram intakes (%grams). We defined elevated cardiac biomarkers as hs-cTnI > 12 ng/L in men and >10 ng/L in women, hs-cTnT ≥ 14 ng/L for all participants, and NT-proBNP ≥ 125 pg/mL for age < 75 y and ≥450 pg/mL for age ≥ 75 y. We used multivariable logistic regression with adjustment for socio-demographic, total energy intake, behavioral, and clinical characteristics. Results: Higher ultra-processed food intake in %grams was associated with elevated NT-proBNP [odds ratio (OR) for quartile 4 vs. 1: 1.27, 95% CI: 1.00–1.61] when socio-demographic characteristics and total energy intake were adjusted for, but this was not the case with hs-cTnI or hs-cTnT. Further adjusting for clinical characteristics attenuated the association with NT-proBNP (OR: 1.26, 95% CI: 0.98, 1.61). There was no consistent association between ultra-processed food in %kcal and elevated NT-proBNP, hs-cTnT, or hs-cTnI. Conclusions: Ultra-processed food consumption is associated with subclinical myocardial stretch, a precursor to early heart failure. This supports the potential risks of subclinical cardiovascular disease associated with consuming ultra-processed food. Full article