Pharmacokinetic Modeling and Optimal Experimental Design: Applications and Prospects
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 555
Special Issue Editors
Interests: antimicrobial agents; pharmacokinetics; pharmacodynamics; PK/PD integration; residues; veterinary pharmacology
Special Issues, Collections and Topics in MDPI journals
Interests: PKPD models; antimicrobial agents; pharmacokinetics; pharmacodynamics; residues; veterinary pharmacology; pharmacobotany
Special Issue Information
Dear Colleagues,
In recent years, pharmacokinetic (PK) modeling has become an essential tool in drug development, clinical pharmacology, veterinary medicine, and regulatory science. From defining optimal dosing regimens to understanding variability across populations and species, pharmacokinetic (PK) modeling provides a mechanistic framework for interpreting drug concentration-time profiles and predicting therapeutic outcomes.
This Special Issue aims to bring together high-quality original research and critical reviews that advance the field of pharmacokinetic modeling and its integration with optimal experimental design (OED). Optimal design methods enable researchers to maximize the efficiency and informativeness of experiments, minimize the use of animals and humans, and accelerate the translation of science. These approaches are especially relevant in light of regulatory, ethical, and economic constraints in both human and veterinary drug development.
We welcome submissions covering a wide range of topics, including but not limited to:
- Novel PK modeling strategies (compartmental, non-compartmental, and physiologically based);
- Bayesian and population modeling approaches;
- Optimal experimental design in preclinical and clinical pharmacokinetics;
- Applications of PK models to antimicrobial stewardship and resistance mitigation;
- Integration of PK/PD models and simulation tools;
- Applications of modeling in One Health contexts, translational pharmacology, and personalized medicine;
- Machine learning and AI in pharmacokinetic modeling;
- Ethical and regulatory perspectives on model-informed approaches.
This Special Issue aims to explore how advanced pharmacometric tools can optimize drug use, inform regulatory decisions, and foster interdisciplinary collaboration across pharmaceutical, clinical, and veterinary sciences.
We encourage both theoretical and applied contributions. Join us in shaping the future of model-informed drug development and precision therapeutics.
Prof. Dr. Nora Mestorino
Dr. Daniel Buldain
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacokinetic modelling
- optimal experimental design
- PK/PD integration
- model-informed drug development
- bayesian pharmacometrics
- translational pharmacology
- veterinary pharmacology
- precision dosing
- machine learning in pharmacology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
