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Review

188 Citations

18,958 Views

35 Pages

Trends and Challenges in Tumor Anti-Angiogenic Therapies

József Jászai and
Mirko H.H. Schmidt

Cells2019, 8(9), 1102;https://doi.org/10.3390/cells8091102

18 September 2019

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a hallmark of solid tumors. This process is driven by an imbalance between pro- and anti-angiogenic factors dominated by the tissue hypoxia-triggered overproduction of v...

(This article belongs to the Special Issue Angiogenesis in Cancer)

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Review

30 Citations

9,008 Views

31 Pages

Advancing Treatment of Bone Metastases through Novel Translational Approaches Targeting the Bone Microenvironment

Nan Sethakorn,
Erika Heninger,
Cristina Sánchez-de-Diego,
Adeline B. Ding,
Ravi Chandra Yada,
Sheena C. Kerr,
David Kosoff,
David J. Beebe and
Joshua M. Lang

Cancers2022, 14(3), 757;https://doi.org/10.3390/cancers14030757

1 February 2022

Bone metastases represent a lethal condition that frequently occurs in solid tumors such as prostate, breast, lung, and renal cell carcinomas, and increase the risk of skeletal-related events (SREs) including pain, pathologic fractures, and spinal co...

(This article belongs to the Special Issue Understanding the Role of the Microenvironment in the Progression of Tumors)

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