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7 Results Found

  • Article
  • Open Access
18 Citations
3,886 Views
36 Pages

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Steady-State Blood Flow in Microtubes

  • Konstantinos Giannokostas,
  • Yannis Dimakopoulos,
  • Andreas Anayiotos and
  • John Tsamopoulos

13 January 2021

The present work focuses on the in-silico investigation of the steady-state blood flow in straight microtubes, incorporating advanced constitutive modeling for human blood and blood plasma. The blood constitutive model accounts for the interplay betw...

  • Communication
  • Open Access
1 Citations
18,887 Views
11 Pages

Observable Metabolites and Metabolomic Sampling Protocols for Managed African Savanna Elephant (Loxodonta africana) Whole Blood Using H-NMR Spectroscopy

  • Jordan Wood,
  • David R. Morgan,
  • Kimberly Ange-van Heugten,
  • Maria Serrano,
  • Larry J. Minter,
  • Vivek Fellner and
  • Michael K. Stoskopf

28 April 2022

We used nuclear magnetic spectroscopy (NMR) to evaluate the metabolomics of heparinized whole blood drawn from six African savanna elephants (Loxodonta africana) maintained on a well characterized diet. Whole blood samples obtained under behavioral r...

  • Review
  • Open Access
21 Citations
13,629 Views
25 Pages

25 February 2022

Rouleaux (stacked clumps) of red blood cells (RBCs) observed in the blood of COVID-19 patients in three studies call attention to the properties of several enveloped virus strains dating back to seminal findings of the 1940s. For COVID-19, key such p...

  • Article
  • Open Access
16 Citations
8,394 Views
19 Pages

Continuous Percoll Gradient Centrifugation of Erythrocytes—Explanation of Cellular Bands and Compromised Age Separation

  • Felix Maurer,
  • Thomas John,
  • Asya Makhro,
  • Anna Bogdanova,
  • Giampaolo Minetti,
  • Christian Wagner and
  • Lars Kaestner

11 April 2022

(1) Background: When red blood cells are centrifuged in a continuous Percoll-based density gradient, they form discrete bands. While this is a popular approach for red blood cell age separation, the mechanisms involved in banding were unknown. (2) Me...

  • Article
  • Open Access
40 Citations
7,931 Views
43 Pages

Advanced Constitutive Modeling of the Thixotropic Elasto-Visco-Plastic Behavior of Blood: Description of the Model and Rheological Predictions

  • Konstantinos Giannokostas,
  • Pantelis Moschopoulos,
  • Stylianos Varchanis,
  • Yannis Dimakopoulos and
  • John Tsamopoulos

20 September 2020

This work focuses on the advanced modeling of the thixotropic nature of blood, coupled with an elasto-visco-plastic formulation by invoking a consistent and validated model for TEVP materials. The proposed model has been verified for the adequate des...

  • Case Report
  • Open Access
4,800 Views
12 Pages

Waldenström’s Macroglobulinemia in a Normoproteinemic Dog with Atypical Bimorphic Plasmacytoid Differentiation and Monoclonal Gammopathy

  • Maud Guerlin,
  • Kévin Mourou,
  • Valeria Martini,
  • Nicolas Soetart,
  • Stefano Comazzi,
  • Catherine Trumel and
  • Fanny Granat

A 2-year-old neutered female Small Munsterlander dog was presented for an insect bite. Physical examination revealed a poor body condition, a peripheral lymphadenomegaly, and suspected splenomegaly. A complete blood count (Sysmex XN-V) revealed marke...

  • Article
  • Open Access
13 Citations
4,215 Views
10 Pages

Red Blood Cell Morphodynamics in Patients with Polycythemia Vera and Stroke

  • Polina I. Kuznetsova,
  • Anton A. Raskurazhev,
  • Alla A. Shabalina,
  • Anait L. Melikhyan,
  • Irina N. Subortseva and
  • Marine M. Tanashyan

17 February 2022

Polycythemia vera (PV) is a Ph-negative myeloproliferative neoplasm (MPN) which is characterized by erythrocytosis and a high incidence of thrombotic complications, including stroke. The study aimed to evaluate red blood cell (RBC) morphodynamic prop...