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9 Results Found

  • Article
  • Open Access
3 Citations
1,877 Views
13 Pages

Roseoside Is a Bioactive Compound in Kirengeshoma koreana Nakai Extract with Potent In Vitro Antiviral Activity Against Hepatitis C Virus

  • Jun-Kyu Lee,
  • Ji-Wan Choi,
  • InWha Park,
  • Na-Eun Kim,
  • Hak Cheol Kwon,
  • Jaeyoung Kwon and
  • Yoon-Jae Song

30 October 2024

Hepatitis C virus (HCV) is a pathogen that causes cirrhosis and hepatocellular carcinoma through chronic hepatitis C. This study focused on the anti-HCV activity of a 70% ethanol extract of Kirengeshoma koreana Nakai (KKE) and its bioactive chemical...

  • Article
  • Open Access
21 Citations
5,492 Views
13 Pages

Inhibitory Effects of Roseoside and Icariside E4 Isolated from a Natural Product Mixture (No-ap) on the Expression of Angiotensin II Receptor 1 and Oxidative Stress in Angiotensin II-Stimulated H9C2 Cells

  • Eun Young Hong,
  • Tae Yang Kim,
  • Gwan Ui Hong,
  • Hanna Kang,
  • Jung-Yun Lee,
  • Jae Yeo Park,
  • Se-Chan Kim,
  • Young Ho Kim,
  • Myung-Hee Chung and
  • Jai Youl Ro

23 January 2019

Hypertension is a major risk factor for the development of cardiovascular diseases. This study aimed to elucidate whether the natural product mixture No-ap (NA) containing Pine densiflora, Annona muricate, and Monordica charantia, or its single compo...

  • Article
  • Open Access
482 Views
18 Pages

Phytochemical Profile, Toxicity Evaluation and Antinociceptive Effect of the n-Butanolic Fraction from the Leaves of Calotropis procera (Aiton) W.T Aiton (Apocynaceae)

  • Kailane Lourenço Araújo,
  • Natanael Teles Ramos de Lima,
  • Pedro Artur Ferreira Marinho,
  • Dara Rayanne da Silva Guedes,
  • Marcelo Sobral da Silva,
  • Yuri Mangueira do Nascimento,
  • Josean Fechine Tavares,
  • José Maria Barbosa Filho,
  • Cinthya Maria Pereira de Souza and
  • Alisson Macário de Oliveira
  • + 2 authors

27 November 2025

Calotropis procera, known as “Silk cotton”, stands out for the presence of various classes of bioactive compounds responsible for its ethnopharmacological properties. The study aimed to conduct a phytochemical investigation, evaluating th...

  • Article
  • Open Access
5 Citations
5,110 Views
25 Pages

Improved Skin Barrier Function Along with Hydration Benefits of Viola yedoensis Extract, Aesculin, and Schaftoside and LC-HRMS/MS Dereplication of Its Bio-Active Components

  • Sreelatha Thonthula,
  • Sandra De Sousa,
  • Alexis Dubuis,
  • Samia Boudah,
  • Richa Mehta,
  • Akanksha Singh,
  • Joan Eilstein,
  • Jean-Claude Tabet,
  • Sherluck John and
  • Steve Thomas Pannakal

27 November 2024

The skin hydration level is a key factor that influences the physical and mechanical properties of the skin. The stratum corneum (SC), the outermost layer of the epidermis, is responsible for the skin’s barrier function. In this study, we inves...

  • Article
  • Open Access
18 Citations
5,059 Views
11 Pages

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

  • Almir Ribeiro de Carvalho Junior,
  • Rafaela Oliveira Ferreira,
  • Michel de Souza Passos,
  • Samyra Imad da Silva Boeno,
  • Lorena de Lima Glória das Virgens,
  • Thatiana Lopes Biá Ventura,
  • Sanderson Dias Calixto,
  • Elena Lassounskaia,
  • Mario Geraldo de Carvalho and
  • Ivo Jose Curcino Vieira

15 March 2019

A phytochemical study of leaves and twigs of Psychotria nuda resulted in 19 compounds, including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, and 5α-carboxystrictosidine; two flavonolignans, cinchon...

  • Article
  • Open Access
1 Citations
1,976 Views
19 Pages

Cytotoxic Natural Products from Cryptomeria japonica (Thunb. ex L.) D.Don

  • Bjørn Tobiassen Heieren,
  • Anja Strandvoll Dyrdal,
  • Lars Herfindal,
  • Bjarte Holmelid,
  • Cato Brede,
  • Heidi Lie Andersen and
  • Torgils Fossen

23 December 2024

Cryptomeria japonica is a commercially important tree native to Japan. The tree belongs to the ancient genus Cryptomeria and has found important uses as a medicinal plant, as well as a main source of timber in Japan. In recent years, there has been a...

  • Article
  • Open Access
2 Citations
1,532 Views
14 Pages

Lactuca racemosa Willd., Source of Antioxidants with Diverse Chemical Structures

  • Klaudia Michalska,
  • Danuta Jantas,
  • Janusz Malarz,
  • Klaudia Jakubowska,
  • Wojciech Paul and
  • Anna Stojakowska

18 December 2024

Ethanolic extracts from the roots and aerial parts of the hitherto chemically uninvestigated lettuce species Lactuca racemosa Willd. (Cichorieae, Asteraceae) were chromatographically separated to obtain eight sesquiterpenoids, two apocarotenoids (lol...

  • Article
  • Open Access
32 Citations
5,608 Views
23 Pages

Phenolic Profile, Toxicity, Enzyme Inhibition, In Silico Studies, and Antioxidant Properties of Cakile maritima Scop. (Brassicaceae) from Southern Portugal

  • Chloé Placines,
  • Viana Castañeda-Loaiza,
  • Maria João Rodrigues,
  • Catarina G. Pereira,
  • Azzurra Stefanucci,
  • Adriano Mollica,
  • Gokhan Zengin,
  • Eulogio J. Llorent-Martínez,
  • Paula C. Castilho and
  • Luísa Custódio

22 January 2020

Cakile maritima Scop. (sea rocket) is an edible halophyte plant with several ethnomedicinal uses. This work reports the chemical profile and bioactivities of food grade extracts from sea rocket organs. Toxicity was determined on mammalian cells, and...

  • Article
  • Open Access
2 Citations
1,565 Views
24 Pages

Phytochemical Profiling of Processed Açaí Pulp (Euterpe oleracea) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats

  • Jefferson Romáryo Duarte da Luz,
  • Eder Alves Barbosa,
  • Rubiamara Mauricio de Sousa,
  • Maria Lúcia de Azevedo Oliveira,
  • Marcela Fabiani Silva Dias,
  • Ingrid Reale Alves,
  • Gisele Custódio de Souza,
  • Elenilze Figueiredo Batista Ferreira,
  • Carla Guzmán-Pincheira and
  • Gabriel Araujo-Silva

The antioxidant capacity and modulation of oxidative stress by industrially processed açaí pulp extract from the Amazon (APEA) and its major anthocyanins, cyanidin 3-glucoside (C3G) and cyanidin-3-O-rutinoside (C3R), were evaluated as p...