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Article

1 Citations

1,210 Views

22 Pages

Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia

Kang Li,
Xiaomei Ge,
Wei Liu,
Lei Huang,
Xinye Lv,
Yuhui Tang,
Zhehao He,
Yingxue Yang,
Miaofen Chen and
Pi Cheng
+ 1 author

Int. J. Mol. Sci.2025, 26(6), 2727;https://doi.org/10.3390/ijms26062727

18 March 2025

B-cell lymphoma-2 (Bcl-2) family proteins are fundamental regulators of intrinsic cell apoptosis, and overexpression of apoptotic proteins (Bcl-2 and Mcl-1) is a characteristic of many haematological malignancies. Thus, it is necessary to discover no...

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Article

27 Citations

5,568 Views

13 Pages

Chemical Characterization of Plant Extracts and Evaluation of their Nematicidal and Phytotoxic Potential

Raúl Velasco-Azorsa,
Héctor Cruz-Santiago,
Ignacio Cid del Prado-Vera,
Marco Vinicio Ramirez-Mares,
María del Rocío Gutiérrez-Ortiz,
Norma Francenia Santos-Sánchez,
Raúl Salas-Coronado,
Claudia Villanueva-Cañongo,
Karla Isabel Lira-de León and
Beatriz Hernández-Carlos

Molecules2021, 26(8), 2216;https://doi.org/10.3390/molecules26082216

12 April 2021

Nacobbus aberrans ranks among the “top ten” plant-parasitic nematodes of phytosanitary importance. It causes significant losses in commercial interest crops in America and is a potential risk in the European Union. The nematicidal and phytotoxic acti...

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Article

9 Citations

3,261 Views

14 Pages

Constituents of Pulicaria inuloides and Cytotoxic Activities of Two Methoxylated Flavonols

Janusz Malarz,
Klaudia Michalska,
Agnieszka Galanty,
Anna Karolina Kiss and
Anna Stojakowska

Molecules2023, 28(2), 480;https://doi.org/10.3390/molecules28020480

4 January 2023

Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roo...

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Article

50 Citations

8,745 Views

15 Pages

Phytochemical Profile, Antioxidant Activity, and Cytotoxicity Assessment of Tagetes erecta L. Flowers

Ana Flavia Burlec,
Łukasz Pecio,
Solomiia Kozachok,
Cornelia Mircea,
Andreia Corciovă,
Liliana Vereștiuc,
Oana Cioancă,
Wiesław Oleszek and
Monica Hăncianu

Molecules2021, 26(5), 1201;https://doi.org/10.3390/molecules26051201

24 February 2021

Tagetes erecta L. is a popular ornamental plant of the Asteraceae family, which is widely cultivated not only for its decorative use, but also for the extraction of lutein. Besides carotenoid representatives, which have been extensively studied, othe...

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Article

12 Citations

2,951 Views

27 Pages

Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae)

Reneta Gevrenova,
Ivanka Kostadinova,
Alexandra Stefanova,
Vessela Balabanova,
Gokhan Zengin,
Dimitrina Zheleva-Dimitrova and
Georgi Momekov

Plants2023, 12(15), 2755;https://doi.org/10.3390/plants12152755

25 July 2023

This study aimed at the evaluation of the antioxidant and cognitive-enhancing effect of methanol–aqueous extract from Helichrysum italicum ssp. italicum aerial parts. Significant radical scavenging activity (110.33 ± 3.47 and 234.70 &plu...

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Article

13 Citations

3,355 Views

16 Pages

Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway

Emre Sahin,
Cemal Orhan,
Nurhan Sahin,
Muralidhara Padigaru,
Abhijeet Morde,
Mohan Lal,
Nanasaheb Dhavan,
Fusun Erten,
Ahmet Alp Bilgic and
Kazim Sahin
+ 1 author

Pharmaceuticals2023, 16(11), 1543;https://doi.org/10.3390/ph16111543

1 November 2023

Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise in supporting eye health. In this study, the impact of...

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