Search Results (973)

We present state-of-the-art kinetic theory determination of the neutron abundance available for the Big-Bang nucleosynthesis (BBN). This paper is motivated by the study of the neutron lifespan measured in the laboratory and the unknown strength of weak interactions coupling constant $G_{\mathrm{F}}$ at finite temperature in the primordial Universe. We draw attention to the relevant dependence of $G_{\mathrm{F}}$ on the symmetry breaking Weinberg angle $s_{\mathrm{W}}^2$, which is a free parameter in the standard model of particle physics. We establish how the value of $s_{\mathrm{W}}^2$ by way of $G_{\mathrm{F}}$ modification influences the neutron abundance available for BBN and neutron lifetime. Full article

Purpose: Lymphopenia is a common adverse event following radiotherapy, but its prognostic relevance following comprehensive involved-site radiation (ISRT) for oligometastatic disease is unknown. We evaluated lymphocyte kinetics after ISRT for oligometastases and tested whether treatment-related lymphopenia was associated with overall survival (OS) and modified progression-free survival (mPFS). Patients and Methods: We performed a single-institution registry study of consecutive patients with 1 to 5 distant metastases treated with comprehensive ISRT by a single radiation oncologist from 2014 to 2023. Systemic therapy was administered at clinician discretion. Absolute lymphocyte count (ALC) was collected at baseline, during radiation and at 1, 3 and 12 months after radiotherapy. Lymphopenia was graded using CTCAE v5.0 (grade 1, ALC < 1000 cells/µL; grade ≥ 3, ALC < 500 cells/µL). OS and mPFS (defined as death or metastatic progression not salvageable with further local therapy) were estimated by the Kaplan–Meier method. Associations were evaluated using univariable and multivariable Cox proportional hazards models. Results: Among 177 patients, the 5-year OS was 39.6% and the median OS was 42.8 months. Median ALC declined from 1400 cells/µL at baseline to 800 cells/µL during radiotherapy (p < 0.01) and 700 cells/µL at a median of 0.7 months after radiation (p < 0.01). Partial recovery was observed at 1000 cells/µL at 3 months (p < 0.001) and 1000 cells/µL at 1 year (p < 0.01). Baseline ALC <1000 cells/µL was associated with worse OS on univariable analysis (p = 0.04) but not on multivariable analysis. Although 27% developed grade ≥ 3 lymphopenia within 3 months of radiation, the 5-year overall survival was 41.4% without lymphopenia versus 31.9% with lymphopenia (p = 0.60). On multivariable analysis, ECOG performance status (HR 1.9, p < 0.01), age (HR 1.04, p < 0.01), albumin (HR 0.6, p = 0.03), and pre-radiation chemotherapy (HR 3.1, p < 0.01) independently predicted overall survival. Conclusions: Comprehensive ISRT for oligometastatic disease was associated with a sustained decrease in median ALC. Treatment-related lymphopenia was not independently associated with OS in this heterogeneous cohort. The disease control benefit of metastasis-directed therapy may outweigh potential detrimental immunologic effects of radiation-induced lymphopenia. Full article

Lead (Pb²⁺) and cadmium (Cd²⁺) are among the most hazardous heavy metal pollutants in wastewater owing to their high toxicity, environmental persistence, and detrimental impacts on human health and aquatic ecosystems. In this study, a novel ternary magnetic composite, SnFe₂O₄/activated carbon/polypyrrole (SnFe₂O₄/AC/PPy), was effectively synthesized and tested as an effective adsorbent in the removal of Pb²⁺ and Cd²⁺ from aqueous water. The composite was prepared by depositing spinel SnFe₂O₄ nanoparticles on activated carbon, followed by in situ polymerization of polypyrrole to enhance surface functionality and adsorption affinity. The successful fabrication of the porous SnFe₂O₄/AC/PPy hybrid composite was confirmed through FTIR, XRD, SEM–EDS, BET, XPS, and VSM characterization. The composite demonstrated a relatively high surface area (352.3 m²/g) and adequate magnetic responsiveness (12.33 emu/g), ensuring facile magnetic separation following wastewater treatment. Batch adsorption experiments showed great removal efficiency of 95.02 and 92.48% for Pb²⁺ and Cd²⁺ ions, respectively, at optimum conditions. The adsorption equilibrium data followed the Langmuir isotherm model with maximum adsorption capacities of 187.07 mg/g for Pb²⁺ and 96.45 mg/g for Cd²⁺ ions, which were attributed to monolayer adsorption on homogenous active sites. The kinetic and isothermal model indicated that the adsorption process was controlled by the combination of physical and chemical interactions. Thermodynamic parameters showed negative Gibbs free energy and enthalpy changes (ΔH° = −49.74 kJ/mol for Pb²⁺ and −38.82 kJ/mol for Cd²⁺ ions), confirming the spontaneous and exothermic nature of adsorption. Furthermore, the increasingly negative ΔG° values at lower temperatures indicated that the adsorption was thermodynamically more favorable under cooler conditions. According to the regeneration studies, the composite maintained a high removal efficiency after five consecutive cycles. In general, SnFe₂O₄/AC/PPy composite has good potential as a stable, reusable, and high-performance adsorbent to treat heavy metal wastewater. Full article

Fiber-reinforced polymer (FRP) composites are extensively used in aerospace, civil engineering, and defense applications because of their low density, high specific strength, corrosion resistance, and structural design flexibility. However, prolonged exposure to hygrothermal conditions, ultraviolet (UV) radiation, and thermo-oxidative environments can progressively damage these materials, leading to mechanical degradation and shortened service life. This review examines environmental aging in FRP composites at the levels of the polymer matrix, fiber/matrix interface, and reinforcing fibers. Representative predictive models, finite element methods, and experimental characterization techniques are summarized, together with the evolution of mechanical properties under different aging conditions. Hygrothermal degradation is mainly associated with moisture diffusion, matrix swelling, and interfacial debonding, whereas UV and thermo-oxidative aging are largely governed by photo-oxidation and thermally activated free-radical reactions. These processes may induce chain scission, crosslinking, matrix embrittlement, and interface damage. Under coupled environmental exposure, degradation is not simply additive because moisture transport, oxidation kinetics, and failure pathways may interact. Future research should emphasize multiscale characterization, anti-aging modification, interface engineering, protective coatings, and reliability-oriented lifetime prediction. Full article

Poor aqueous solubility and consequently low bioavailability of various NSAIDs (non-steroidal anti-inflammatory drugs) usually result in high and multiple dosing with potentially serious side effects. Therefore, systems for the effective transport of NSAIDs through the GIT (gastrointestinal tract), ensuring enhanced bioavailability, remain in high demand. In the present work, we studied chitosan (CS) hydrogel lyophilizates as carrier systems for a model NSAID, namely ibuprofen (IBU). The CS-IBU lyophilizates were prepared from homogeneous or heterogeneous CS-IBU hydrogels to assess their influence on the resulting lyophilizate microstructure and IBU dissolution profiles. To gain a complex view of the CS-IBU behavior and its practical consequences, dissolution profiles of free IBU (reference) and CS-associated IBU (CS-IBU) were examined and compared to each other at variable pH (1.2 and 6.5) in two separate dissolution systems and in one discontinuous dissolution system mimicking GIT conditions. The results of dissolution experiments were supported by kinetic model data. This study demonstrated that the dissolution of IBU from the CS-IBU lyophilizates is affected by two main pH-dependent competitive effects; i.e., dissolved CS acts as an IBU solubilizer and the undissolved CS matrix serves as an IBU trap, which could be used in the rational design of innovative stimuli (pH)-responsive oral dosage forms of IBU. Full article

Excessive application of chemical preservatives has raised increasing concerns regarding food safety and human health, prompting the search for safer natural alternatives. Lavender essential oil (LEO), a plant-derived antimicrobial agent, has been considered a promising substitute for synthetic preservatives, but its high volatility and poor water solubility limit its practical application. In this study, LEO nanoemulsions were fabricated via high-pressure homogenization using sodium caseinate (SC) and tea polyphenols (TPs) as composite emulsifiers. The preparation process was optimized using a three-factor, three-level orthogonal design, and the physicochemical properties, storage stability, and antibacterial activity were systematically investigated. The optimal preparation conditions were determined as an SC/TP mass ratio of 2:1, homogenization pressure of 70 MPa, and 7 homogenization cycles. The optimized nanoemulsion exhibited a droplet size of 130–210 nm, zeta potential of −30.89 mV, and encapsulation efficiency of 98.61%, with typical shear-thinning behavior and excellent storage stability. The percentage of free LEO remained below 7.5% within 15 days, indicating high stability, and the release behavior followed a zero-order kinetic model. The prepared nanoemulsion showed significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with a minimum inhibitory concentration (MIC) of 62.5 μg/mL for both strains. This study confirms that the SC/TP composite interface can effectively stabilize LEO nanoemulsions, providing a theoretical basis for the development of natural and efficient food preservatives. Full article

The consumption of vegetable oils is steadily increasing, especially in Asian countries. Once used, the utilized cooking oils are either thrown into landfills or dumped there, endangering both the environment and people. One common method is to convert waste cooking oil (WCO) into biofuel; however, since WCO contains many free radicals, burning it releases large quantities of pollutants, meaning that disposal of WCO poses significant environmental risks. To stabilize the WCO (Cocos nucifera) before converting it into biofuel, this study analyzed the extraction, optimization, and use of antioxidant-rich bio-oil from Anisomeles malabarica leaves as a natural additive. Solvent screening revealed that a hexane–ethanol ratio of 4:2 was optimal for generating 76.7% bio-oil at room temperature. A maximum yield of 77% was attained by temperature and time optimization, which determined that 50 °C and 20 min were ideal. The extraction exhibits zero-order kinetics during the increasing phase, according to kinetic studies, with rate constants ranging from 0.54 to 1.44% min⁻¹ (R² = 0.950–0.997). The Peleg equilibrium model (average R² = 0.806) was used to describe the extraction profile. The regression equation ln(k) = 1799.3 × (1/T) − 10.828 (R² = 0.9748, p = 0.0002) was obtained using Arrhenius analysis. It was found that the compounds responsible for the antioxidant scavenging activity were found to be phytol, hexadecenoic acid, and tocopherol (vitamin E). The DPPH (2,2-diphenyl-1-picrylhydrazyl) test confirmed that 3% (v/v) bio-oil scavenged about 95% of free radicals, whereas the conjugated diene experiment demonstrated that over 90% of lipid oxidation in WCO was prevented. The combustion and emission properties of biofuel (WCB), which was created by transesterifying bio-oil-treated WCO, were compared to those of neat diesel and untreated WCO-derived biofuel (WC). In comparison to both WC50 and neat diesel, WCB50 demonstrated an equivalent in-cylinder pressure and heat release rate, but significantly reduced emissions of NO_x, CO, hydrocarbons, and smoke. These results show that Anisomeles malabarica bio-oil works well as a natural antioxidant addition for clean combustion and biodiesel stabilization. Full article

Background and Objectives: Metastatic castration-resistant prostate cancer (mCRPC) remains a clinically heterogeneous condition despite ongoing advances in systemic treatment. Androgen receptor pathway inhibitors (ARPIs), including abiraterone acetate and enzalutamide, have been associated with improved clinical outcomes; however, early identification of patients deriving limited benefit continues to be challenging. Prostate-specific antigen (PSA) kinetics may serve as a practical indicator of treatment response over time. This study aimed to examine the prognostic significance of achieving a ≥50% reduction in PSA levels at three months in patients with mCRPC treated with ARPIs in routine clinical practice. Materials and Methods: In this retrospective single-center study, patients with mCRPC who received abiraterone acetate or enzalutamide between February 2015 and March 2024 were included. Patients were stratified according to PSA decline at three months (≥50% vs. <50%). Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method and compared with the log-rank test. Prognostic variables were subsequently examined using univariate and multivariate Cox proportional hazards models. Results: A total of 60 patients were included. At three months, 44 patients (73.3%) achieved a ≥50% decline in PSA levels. Patients reaching this level had longer PFS and OS than those with <50% decline, and the differences between groups were statistically significant. In multivariate analysis, early PSA decline remained significantly associated with improved survival outcomes. Conclusions: A ≥50% decline in PSA levels at three months represents a simple and clinically meaningful indicator of treatment response in patients with mCRPC receiving ARPIs. Early PSA kinetics may assist in timely risk stratification and closer clinical monitoring in routine clinical practice. Full article

Rapid dissolution of conventional fertilizers causes low nutrient-use efficiency and serious leaching losses, contributing to agricultural non-point source pollution. In this study, biomass-based slow-release fertilizer beads were prepared by ionic crosslinking of potato starch (ST), chitosan (CS), and corn-straw biochar (BC), using potassium nitrate (KNO₃) as the model nutrient. The effects of ST/CS ratio and BC incorporation on bead structure, swelling, nutrient loading, release kinetics, and soil-column leaching were systematically investigated. Biochar incorporation formed a more compact and interconnected porous network and reduced the equilibrium swelling ratios of ST90/CS10, ST80/CS20, and ST70/CS30 from 188%, 176%, and 164% to 168%, 136%, and 104%, respectively. Although BC slightly decreased KNO₃ loading capacity, it markedly slowed nutrient release; ST80/CS20/BC20 released 31.09%, 50.09%, and 81.82% of loaded KNO₃ at 24, 72, and 504 h, respectively, which were 28.40%, 25.27%, and 11.30% lower than those of ST80/CS20. Kinetic fitting indicated that BC reduced the apparent release rate and promoted diffusion-controlled release behavior. Soil-column experiments further showed that the beads reduced NO₃⁻-N and K⁺ leaching compared with free KNO₃, with ST80/CS20/BC20 showing the best balance between nutrient loading and release control. These results suggest that starch–chitosan–biochar beads are a promising biodegradable matrix for slow-release fertilizer applications. Full article

The nucleation and growth mechanisms of copper electrodeposition from Cu(I)-containing-reline, a deep eutectic solvent, were investigated through a combination of electrochemical techniques and surface characterization. Cyclic voltammetry revealed the characteristic nucleation loop associated with an overpotential-driven electrocrystallization process, from which the equilibrium potential of the Cu(I)/Cu(0) redox couple was determined to be −0.35 V vs. a Ag quasi-reference electrode. Experimental potentiostatic current density transients were analyzed using nucleation models capable of accounting for both adsorption and three-dimensional (3D) diffusion-controlled growth, thereby allowing deconvolution of the individual contributions to the overall current response. The kinetic parameters, including the nucleation frequency and the number density of active sites, exhibited an exponential dependence on the applied overpotential, thus indicating enhanced nucleation kinetics at greater driving forces, while determining a Cu(I) diffusion coefficient of (3.39 + 0.09) × 10⁻⁷ cm² s⁻¹. Thermodynamic analysis showed that the Gibbs free energy of the formation of the critical nucleus decreases with increasing overpotential and follows the expected dependence on the inverse square of the overpotential, in agreement with classical nucleation theory. The estimated critical nucleus size was found to be smaller than one atom, suggesting that nucleation occurs at highly active surface sites. Furthermore, an exchange current density of (3 ± 1) μA cm⁻² was estimated for the Cu(I) electrochemical reduction. Scanning electron microscopy revealed a high density of copper nanoparticles (~20 nm) distributed across the electrode surface, along with larger aggregates (~100 nm) formed by coalescence and growth, consistent with a progressive nucleation mechanism. X-ray photoelectron spectroscopy confirmed that the deposits consist exclusively of metallic copper, with no evidence of oxidized species. These results demonstrate that copper electrodeposition in reline is governed by a complex interplay between the thermodynamic driving force, the interfacial kinetics, and mass transport, comprehensively providing fundamental insight into the electrocrystallization processes in deep eutectic solvents. Full article

A high quality factor, denoted as the Q-factor, is crucial for micromachined disk resonator gyroscopes, commonly referred to as DRGs, to suppress thermomechanical noise and improve bias stability. However, the coupled energy dissipation mechanisms under low-pressure conditions impose significant limitations on further Q-factor enhancement. This paper establishes a rigorous multiphysics damping analysis framework for DRGs and quantitatively investigates the contributions of air damping, thermoelastic damping, and anchor loss. A free-molecular squeeze-film damping model is derived based on kinetic gas theory and molecular energy transfer mechanisms, avoiding the continuous fluid assumption of the classical Reynolds equation, which fails in low-pressure regimes. Due to the highly symmetric ring structure and central anchor design, finite element method simulations reveal an extremely high anchor-loss-limited quality factor, Q_anchor, of approximately 1.85 × 10¹², indicating negligible anchor-induced dissipation. Under an operating pressure of 0.1 Pa, air damping is validated as the absolute dominant energy dissipation mechanism with a gas quality factor, Q_air, of approximately 1.105 × 10⁵, which is significantly lower than the thermoelastic damping quality factor, Q_TED, evaluated at 8.98 × 10⁵. To break the classical trade-off between squeeze-film damping suppression and capacitive drive efficiency, a decoupled gap optimization strategy is proposed. By maintaining the drive electrode gap, gap_e, at 7.2 µm while increasing only the parasitic ring-to-suspended-mass gap, gap_m, to 12 µm, the squeeze-film-damping-limited Q-factor is improved by approximately 25% to 1.381 × 10⁵ without degrading electromechanical coupling efficiency. In addition, the optimal anchor radius is determined to be approximately 160 µm. The proposed framework provides practical design guidance for high-Q DRGs and other MEMS resonant inertial sensors. Full article

Traditional solid-contact ion-selective electrodes (SC-ISEs) are severely constrained by a long-standing thermodynamic bottleneck, which requires hours of pre-conditioning and stabilization to establish a stable phase-boundary potential. To fundamentally bypass this limitation, we present a paradigm shift in electrochemical ion sensing that exploits dynamic kinetics rather than waiting for thermodynamic equilibrium. In this paper, we report a transient potential profiling method that eliminates the need for equilibration by analyzing the open-circuit voltage decay during the first 60 s of polarization. A discharge step on indicator electrode returns the membrane to a reproducible initial state, allowing for the extraction of a concentration correlated coefficient. Using a calcium ISE with an optimized membrane, the early-stage polarization dynamics were fitted to a single exponential saturation model, predicting the steady state response with an average error of 1.6%. The method achieved high repeatability (intra-day RSD 3.22%), batch to batch reproducibility (4.57%), and recovery rates from 90.7% to 115.0% in real water samples. Validation against ion chromatography showed high agreement (R² = 0.997). This strategy enabled conditioning free, disposable ISEs for point of care and environmental monitoring. Full article

We propose an exploratory framework for a Bohmian model of quantum matter propagating on a classical curved spacetime background. The gravitational sector is governed by classical Einstein field equations throughout; no quantisation of spacetime is attempted. The wave function emerges as the scalar contraction $\mathrm{\Psi }={\psi }_{\nu }{\psi }^{\nu }\in \mathbb{C}$ of a complex-valued tensorial field ${\psi }^{\mu }$, encoding quantum dynamics in a geometric object. The wave tensor interacts with spacetime via the stress–energy tensor $T_{\mu \nu }$, mediated by a real scalar field a of dimension volume, so that $a{T}_{\mu \nu }{\psi }^{\mu }{\psi }^{\nu }$ yields the correct potential energy. We derive a covariant Adapted Schrödinger Equation as the unique minimal covariant lift of the standard equation, justify it from four guiding principles, and verify three internal consistency checks. Under seven explicit approximations the framework reproduces the Schrödinger equation with Coulomb potential for the hydrogen atom. We also derive a dynamical equation for ${\psi }^{\mu }$ that entails the Adapted Schrödinger Equation by contraction. Two open problems are then resolved. First, a complete Lagrangian formulation is provided: a real-valued action for $\mathrm{\Psi }$ yields the Adapted Schrödinger Equation via the Euler–Lagrange equations; a separate action for ${\psi }^{\mu }$, extended by a non-polynomial term, yields the full dynamical equation variationally. Second, two experimental predictions are derived. Expanding to first post-Newtonian order, the perturbation Hamiltonian has coefficients $(3, 1)$ on the kinetic and potential operators; via the virial theorem these produce a coordinate-time blueshift, which after photon propagation yields the universal Einstein gravitational redshift $\delta \nu /\nu =\mathrm{\Phi }/c^2$, confirming consistency with the equivalence principle. The same kinetic coefficient independently predicts that free quantum wave packets spread more slowly by the fractional amount $3\left|\mathrm{\Phi }\right|/c^2$, a correction absent in standard non-relativistic quantum mechanics. Full article

Background/Objectives: Lipid-based nanocarriers have emerged as promising systems for improving the delivery of poorly soluble drugs by enhancing stability, bioavailability, and controlled release. This work aimed to formulate solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) containing ciprofloxacin (CIP) using solvent-free procedures. Methods: The systems were extensively characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), and atomic force microscopy (AFM) to study the nanoparticles in the solid state. Furthermore, in vitro drug release was evaluated, and mathematical modeling was applied to analyze the resulting release kinetics. Additionally, storage stability was assessed at 4 °C and 25 °C over a period of 8 months. Results: The results indicated that SLN with an average size of ~50 nm (SLN 50) and NLC with mean diameters of ~25, 50, and 100 nm (NLC 25, NLC 50 and NLC 100 respectively) were successfully prepared. DLS measurements showed narrow particle size distributions (PdI ≤ 0.2) and negative zeta potentials ranging from −3.7 to −7.7 mV. Encapsulation efficiencies were remarkably high for most systems, reaching ~98% for SLN 50, NLC 50, and NLC 100, while the smallest formulation (NLC 25) showed a lower efficiency (~80%). Both TEM and AFM confirmed the formation of spherical nanoscale structures consistent with the sizes determined by DLS. Release studies revealed a strong influence of particle size on kinetics: NLC 25 exhibited rapid release (~95% within 30 min), whereas NLC 100 showed a sustained profile (<20% after 6 h). Dissolution profiles were accurately described by the Lumped-Gonzo kinetic model (R² > 0.98), enabling estimation of dissolution efficiency. Conclusions: These findings confirm that lipid-based nanocarriers can be engineered to precisely control CIP release. Full article

Background: Uncontrolled hemorrhage, especially at non-compressible sites, remains a major cause of preventable trauma deaths. This study reports the development of fibrinogen-loaded calcium carbonate (CaCO₃) microparticles that combine hemostatic activity with self-propelling capability for targeted delivery against blood flow, with a focus on understanding formulation-dependent trade-offs among particle yield, protein loading, clotting performance, and transport behavior. Methods: Microparticles were synthesized via a precipitation method using different carbonate sources and characterized for yield, morphology, size, and fibrinogen encapsulation. Hemostatic function was assessed using rotational thromboelastometry (ROTEM) in fibrinogen-deficient plasma. Propulsion behavior was evaluated following exposure to protonated tranexamic acid (TXA⁺), which triggers CO₂ generation. Particle size and encapsulation were examined by microscopy and fluorescence imaging. Results: The precipitation method produced spherical micrometer-sized particles, with fibrinogen inclusion reducing yield and particle size relative to unload controls. Fluorescence microscopy confirmed successful encapsulation. Encapsulation efficiency varied with formulation, with sodium carbonate-based particles showing higher relative fibrinogen loading. ROTEM analysis demonstrated that fibrinogen-loaded particles significantly improved clot formation, increasing maximum clot firmness compared to fibrinogen-free particles, although performance remained formulation-dependent. TXA⁺-triggered propulsion achieved maximum speeds up to 4.221 cm/s. Fibrinogen-loaded particles exhibited longer activation lag times than unloaded particles, indicating a trade-off between hemostatic functionality and propulsion kinetics. Conclusions: Fibrinogen-loaded CaCO₃ microparticles exhibit both hemostatic activity and chemically triggered motion in vitro. The study identifies key formulation-dependent trade-offs between particle yield, fibrinogen loading, clotting performance, and propulsion behavior. While these findings support the feasibility of combining localization and clot stabilization mechanisms, further studies under physiologically relevant flow conditions and in vivo models are required to evaluate their potential for active delivery in non-compressible hemorrhage. Full article