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Search Results (8,233)

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14 pages, 2448 KiB  
Article
Study on the Semi-Interpenetrating Polymer Network Self-Degradable Gel Plugging Agent for Deep Coalbed Methane
by Bo Wang, Zhanqi He, Jin Lin, Kang Ren, Zhengyang Zhao, Kaihe Lv, Yiting Liu and Jiafeng Jin
Processes 2025, 13(8), 2453; https://doi.org/10.3390/pr13082453 (registering DOI) - 3 Aug 2025
Abstract
Deep coalbed methane (CBM) reservoirs are characterized by high hydrocarbon content and are considered an important strategic resource. Due to their inherently low permeability and porosity, horizontal well drilling is commonly employed to enhance production, with the length of the horizontal section playing [...] Read more.
Deep coalbed methane (CBM) reservoirs are characterized by high hydrocarbon content and are considered an important strategic resource. Due to their inherently low permeability and porosity, horizontal well drilling is commonly employed to enhance production, with the length of the horizontal section playing a critical role in determining CBM output. However, during extended horizontal drilling, wellbore instability frequently occurs as a result of drilling fluid invasion into the coal formation, posing significant safety challenges. This instability is primarily caused by the physical intrusion of drilling fluids and their interactions with the coal seam, which alter the mechanical integrity of the formation. To address these challenges, interpenetrating and semi-interpenetrating network (IPN/s-IPN) hydrogels have gained attention due to their superior physicochemical properties. This material offers enhanced sealing and support performance across fracture widths ranging from micrometers to millimeters, making it especially suited for plugging applications in deep CBM reservoirs. A self-degradable interpenetrating double-network hydrogel particle plugging agent (SSG) was developed in this study, using polyacrylamide (PAM) as the primary network and an ionic polymer as the secondary network. The SSG demonstrated excellent thermal stability, remaining intact for at least 40 h in simulated formation water at 120 °C with a degradation rate as high as 90.8%, thereby minimizing potential damage to the reservoir. After thermal aging at 120 °C, the SSG maintained strong plugging performance and favorable viscoelastic properties. A drilling fluid containing 2% SSG achieved an invasion depth of only 2.85 cm in an 80–100 mesh sand bed. The linear viscoelastic region (LVR) ranged from 0.1% to 0.98%, and the elastic modulus reached 2100 Pa, indicating robust mechanical support and deformation resistance. Full article
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32 pages, 17593 KiB  
Review
Responsive Therapeutic Environments: A Dual-Track Review of the Research Literature and Design Case Studies in Art Therapy for Children with Autism Spectrum Disorder
by Jing Liang, Jingxuan Jiang, Jinghao Hei and Jiaqi Zhang
Buildings 2025, 15(15), 2735; https://doi.org/10.3390/buildings15152735 (registering DOI) - 3 Aug 2025
Abstract
Art therapy serves as a crucial intervention modality for children with autism spectrum disorder (ASD), demonstrating unique value in emotional expression, sensory integration, and social communication. However, current practice presents critical challenges, including the disconnect between design expertise and clinical needs, unclear mechanisms [...] Read more.
Art therapy serves as a crucial intervention modality for children with autism spectrum disorder (ASD), demonstrating unique value in emotional expression, sensory integration, and social communication. However, current practice presents critical challenges, including the disconnect between design expertise and clinical needs, unclear mechanisms of environmental factors’ impact on therapeutic outcomes, and insufficient evidence-based support for technology integration. Purpose: This study aimed to construct an evidence-based theoretical framework for art therapy environment design for children with autism, clarifying the relationship between environmental design elements and therapeutic effectiveness. Methodology: Based on the Web of Science database, this study employed a dual-track approach comprising bibliometric analysis and micro-qualitative content analysis to systematically examine the knowledge structure and developmental trends. Research hotspots were identified through keyword co-occurrence network analysis using CiteSpace, while 24 representative design cases were analyzed to gain insights into design concepts, emerging technologies, and implementation principles. Key Findings: Through keyword network visualization analysis, this study identified ten primary research clusters that were systematically categorized into four core design elements: sensory feedback design, behavioral guidance design, emotional resonance design, and therapeutic support design. A responsive therapeutic environment conceptual framework was proposed, encompassing four interconnected components based on the ABC model from positive psychology: emotional, sensory, environmental, and behavioral dimensions. Evidence-based design principles were established emphasizing child-centeredness, the promotion of multisensory expression, the achievement of dynamic feedback, and appropriate technology integration. Research Contribution: This research establishes theoretical connections between environmental design elements and art therapy effectiveness, providing a systematic design guidance framework for interdisciplinary teams, including environmental designers, clinical practitioners, technology developers, and healthcare administrators. The framework positions technology as a therapeutic mediator rather than a driver, ensuring technological integration supports rather than interferes with children’s natural creative impulses. This contributes to creating more effective environmental spaces for art therapy activities for children with autism while aligning with SDG3 goals for promoting mental health and reducing inequalities in therapeutic access. Full article
(This article belongs to the Special Issue Art and Design for Healing and Wellness in the Built Environment)
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26 pages, 7634 KiB  
Article
Research on the Preparation and Performance of Wood with High Negative Oxygen Ion Release Induced by Moisture
by Min Yin, Yuqi Zhang, Yun Lu, Zongying Fu, Haina Mi, Jianfang Yu and Ximing Wang
Coatings 2025, 15(8), 905; https://doi.org/10.3390/coatings15080905 (registering DOI) - 2 Aug 2025
Abstract
With the growing severity of environmental pollution, people are paying increasing attention to their health. However, naturally occurring wood with health benefits and applications in human healthcare is still scarce. Natural wood exhibits a limited negative oxygen ion release capacity, and this release [...] Read more.
With the growing severity of environmental pollution, people are paying increasing attention to their health. However, naturally occurring wood with health benefits and applications in human healthcare is still scarce. Natural wood exhibits a limited negative oxygen ion release capacity, and this release has a short duration, failing to meet practical application requirements. This study innovatively developed a humidity-responsive, healthy wood material with a high negative oxygen ion release capacity based on fast-growing poplar. Through vacuum cyclic impregnation technology, hexagonal stone powder was infused into the pores of poplar wood, endowing it with the ability to continuously release negative oxygen ions. The healthy wood demonstrated a static average negative oxygen ion release rate of 537 ions/cm3 (peaking at 617 ions/cm3) and a dynamic average release rate of 3,170 ions/cm3 (peaking at 10,590 ions/cm3). The results showed that the particle size of hexagonal stone powder in suspension was influenced by the dispersants and dispersion processes. The composite dispersion process demonstrated optimal performance when using 0.5 wt% silane coupling agent γ-(methacryloxy)propyltrimethoxysilane (KH570), achieving the smallest particle size of 8.93 μm. The healthy wood demonstrated excellent impregnation performance, with a weight gain exceeding 14.61% and a liquid absorption rate surpassing 165.18%. The optimal impregnation cycle for vacuum circulation technology was determined to be six cycles, regardless of the type of dispersant. Compared with poplar wood, the hygroscopic swelling rate of healthy wood was lower, especially in PEG-treated samples, where the tangential, radial, longitudinal, and volumetric swelling rates decreased by 70.93%, 71.67%, 69.41%, and 71.35%, respectively. Combining hexagonal stone powder with fast-growing poplar wood can effectively enhance the release of negative oxygen ions. The static average release of negative oxygen ions from healthy wood is 1.44 times that of untreated hexagonal stone powder, and the dynamic release reaches 2 to 3 times the concentration of negative oxygen ions specified by national fresh air standards. The water-responsive mechanism revealed that negative oxygen ion release surged when ambient humidity exceeded 70%. This work proposes a sustainable and effective method to prepare healthy wood with permanent negative oxygen ion release capability. It demonstrates great potential for improving indoor air quality and enhancing human health. Full article
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37 pages, 3618 KiB  
Review
Lithium Slag as a Supplementary Cementitious Material for Sustainable Concrete: A Review
by Sajad Razzazan, Nuha S. Mashaan and Themelina Paraskeva
Materials 2025, 18(15), 3641; https://doi.org/10.3390/ma18153641 (registering DOI) - 2 Aug 2025
Abstract
The global cement industry remains a significant contributor to carbon dioxide (CO2) emissions, prompting substantial research efforts toward sustainable construction materials. Lithium slag (LS), a by-product of lithium extraction, has attracted attention as a supplementary cementitious material (SCM). This review synthesizes [...] Read more.
The global cement industry remains a significant contributor to carbon dioxide (CO2) emissions, prompting substantial research efforts toward sustainable construction materials. Lithium slag (LS), a by-product of lithium extraction, has attracted attention as a supplementary cementitious material (SCM). This review synthesizes experimental findings on LS replacement levels, fresh-state behavior, mechanical performance (compressive, tensile, and flexural strengths), time-dependent deformation (shrinkage and creep), and durability (sulfate, acid, abrasion, and thermal) of LS-modified concretes. Statistical analysis identifies an optimal LS dosage of 20–30% (average 24%) for maximizing compressive strength and long-term durability, with 40% as a practical upper limit for tensile and flexural performance. Fresh-state tests show that workability losses at high LS content can be mitigated via superplasticizers. Drying shrinkage and creep strains decrease in a dose-dependent manner with up to 30% LS. High-volume (40%) LS blends achieve up to an 18% gain in 180-day compressive strength and >30% reduction in permeability metrics. Under elevated temperatures, 20% LS mixes retain up to 50% more residual strength than controls. In advanced systems—autoclaved aerated concrete (AAC), one-part geopolymers, and recycled aggregate composites—LS further enhances both microstructural densification and durability. In particular, LS emerges as a versatile SCM that optimizes mechanical and durability performance, supports material circularity, and reduces the carbon footprint. Full article
17 pages, 1399 KiB  
Review
Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA
by Andrea Bayona-Hernandez, Ana Miladinović, Ludovica Antiga, Pavel Hozak, Martin Sztacho and Enrique Castano
Cells 2025, 14(15), 1193; https://doi.org/10.3390/cells14151193 (registering DOI) - 2 Aug 2025
Abstract
Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central roles in [...] Read more.
Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central roles in cellular regulation, and growing evidence reveals a complex interplay between these molecules. These interactions contribute to key biological functions, such as cancer progression, lipid droplet transport, autophagy, liquid−liquid phase separation, and the formation of organelles without membranes. Understanding the lipid−lncRNA interface opens new avenues for unraveling cellular regulation and disease mechanisms, holding great potential not only for elucidating the fundamental aspects of cellular biology but also for identifying innovative therapeutic targets for metabolic disorders and cancer. This review highlights the biological relevance of lipid–lncRNA interactions by exploring their roles in cellular organization, regulation, and diseases, including metabolic and cancer-related disorders. Full article
(This article belongs to the Section Cell Microenvironment)
21 pages, 6618 KiB  
Article
Comparison of Deep Learning Models for LAI Simulation and Interpretable Hydrothermal Coupling in the Loess Plateau
by Junpo Yu, Yajun Si, Wen Zhao, Zeyu Zhou, Jiming Jin, Wenjun Yan, Xiangyu Shao, Zhixiang Xu and Junwei Gan
Plants 2025, 14(15), 2391; https://doi.org/10.3390/plants14152391 (registering DOI) - 2 Aug 2025
Abstract
As the world’s largest loess deposit region, the Loess Plateau’s vegetation dynamics are crucial for its regional water–heat balance and ecosystem functioning. Leaf Area Index (LAI) serves as a key indicator bridging canopy architecture and plant physiological activities. Existing studies have made significant [...] Read more.
As the world’s largest loess deposit region, the Loess Plateau’s vegetation dynamics are crucial for its regional water–heat balance and ecosystem functioning. Leaf Area Index (LAI) serves as a key indicator bridging canopy architecture and plant physiological activities. Existing studies have made significant advancements in simulating LAI, yet accurate LAI simulation remains challenging. To address this challenge and gain deeper insights into the environmental controls of LAI, this study aims to accurately simulate LAI in the Loess Plateau using deep learning models and to elucidate the spatiotemporal influence of soil moisture and temperature on LAI dynamics. For this purpose, we used three deep learning models, namely Artificial Neural Network (ANN), Long Short-Term Memory (LSTM), and Interpretable Multivariable (IMV)-LSTM, to simulate LAI in the Loess Plateau, only using soil moisture and temperature as inputs. Results indicated that our approach outperformed traditional models and effectively captured LAI variations across different vegetation types. The attention analysis revealed that soil moisture mainly influenced LAI in the arid northwest and temperature was the predominant effect in the humid southeast. Seasonally, soil moisture was crucial in spring and summer, notably in grasslands and croplands, whereas temperature dominated in autumn and winter. Notably, forests had the longest temperature-sensitive periods. As LAI increased, soil moisture became more influential, and at peak LAI, both factors exerted varying controls on different vegetation types. These findings demonstrated the strength of deep learning for simulating vegetation–climate interactions and provided insights into hydrothermal regulation mechanisms in semiarid regions. Full article
(This article belongs to the Section Plant Modeling)
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22 pages, 24500 KiB  
Article
Ambient to Elevated Temperature: Ecotribology of Water-Based Lubricants Incorporating hBN/TiO2 Nanoadditives
by Afshana Morshed, Fei Lin, Hui Wu, Zhao Xing, Sihai Jiao and Zhengyi Jiang
Lubricants 2025, 13(8), 344; https://doi.org/10.3390/lubricants13080344 (registering DOI) - 1 Aug 2025
Abstract
Ecotribology focuses on both saving energy resources and reducing environmental pollution. Considering environmental concerns, water-based nanolubricants have gained significant attention over conventional oil-based ones. Non-ecotoxic and highly environmentally friendly nanoadditives were chosen for nanolubricant synthesis, especially considering their use at elevated temperatures. In [...] Read more.
Ecotribology focuses on both saving energy resources and reducing environmental pollution. Considering environmental concerns, water-based nanolubricants have gained significant attention over conventional oil-based ones. Non-ecotoxic and highly environmentally friendly nanoadditives were chosen for nanolubricant synthesis, especially considering their use at elevated temperatures. In this study, hexagonal boron nitride nanosheets (hBNNSs) and titanium dioxide nanoparticles (TiO2 NPs) were used to prepare water-based lubricants with glycerol and surfactant sodium dodecyl benzene sulfonate (SDBS) in water under ultrasonication. An Rtec ball-on-disk tribometer was used to investigate the tribological performance of the synthesised water-based lubricants containing different nano-hBN/TiO2 concentrations, with dry and water conditions used as benchmarks. The results indicated that the water-based nanolubricant containing 0.5 wt% hBN and 0.5 wt% TiO2 exhibited the best tribological performance at both ambient (25 °C) and elevated (500 °C) temperatures. This optimal concentration leads to a reduction in the coefficient of friction (COF) by 72.9% and 37.5%, wear of disk by 62.5% and 49%, and wear of ball by 74% and 69% at ambient and elevated temperatures, respectively, compared to that of distilled water. Lubrication mechanisms were attributed to the rolling, mending, tribofilm, solid layer formation, and synergistic effects of hBNNSs and TiO2 NPs. Full article
(This article belongs to the Special Issue Tribology in Manufacturing Engineering)
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11 pages, 6279 KiB  
Communication
Low-Profile Broadband Filtering Antennas for Vehicle-to-Vehicle Applications
by Shengtao Chen and Wang Ren
Sensors 2025, 25(15), 4747; https://doi.org/10.3390/s25154747 (registering DOI) - 1 Aug 2025
Viewed by 44
Abstract
This paper proposes a compact, broadband, and low-profile filtering antenna designed for Sub-6 GHz communication. By applying characteristic mode analysis to the radiating elements, the operational mechanism of the antenna is clearly elucidated. The current cancellation among different radiating elements results in two [...] Read more.
This paper proposes a compact, broadband, and low-profile filtering antenna designed for Sub-6 GHz communication. By applying characteristic mode analysis to the radiating elements, the operational mechanism of the antenna is clearly elucidated. The current cancellation among different radiating elements results in two radiation nulls in the primary radiation direction, effectively enhancing the filtering effect. The antenna achieves a wide operational bandwidth (S1110 dB) of 35.9% (4.3–6.4 GHz), making it highly suitable for Sub-6 GHz communication systems. Despite its compact size of 25 × 25 mm2, the antenna consistently maintains stable broadside radiation patterns, with a peak gain of 6.14 dBi and a minimal gain fluctuation of less than 1 dBi at 4.6–6.45 GHz. This design ensures reliable and robust communication performance for V2V systems operating in the designated frequency band. Full article
(This article belongs to the Section Communications)
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36 pages, 1921 KiB  
Article
Policy Synergies for Advancing Energy–Environmental Productivity and Sustainable Urban Development: Empirical Evidence from China’s Dual-Pilot Energy Policies
by Si Zhang and Xiaodong Zhu
Sustainability 2025, 17(15), 6992; https://doi.org/10.3390/su17156992 (registering DOI) - 1 Aug 2025
Viewed by 98
Abstract
Achieving synergies between government-led and market-based policy instruments is critical to advancing Energy–Environmental Productivity and Sustainable Urban Development. This study investigates the effects of China’s dual-pilot energy policies (New Energy Demonstration Cities (NEDCs) and Energy Consumption Permit Trading (ECPT)) on urban environmental productivity [...] Read more.
Achieving synergies between government-led and market-based policy instruments is critical to advancing Energy–Environmental Productivity and Sustainable Urban Development. This study investigates the effects of China’s dual-pilot energy policies (New Energy Demonstration Cities (NEDCs) and Energy Consumption Permit Trading (ECPT)) on urban environmental productivity (UEP) across 279 prefecture-level cities from 2006 to 2023. Utilizing a Non-Radial Directional Distance Function (NDDF) approach, combined with Difference-in-Differences (DID) estimation and spatial econometric models, the analysis reveals that these synergistic policies significantly enhance both comprehensive and net measures of UEP. Mechanism analysis highlights the roles of industrial restructuring, technological innovation, and energy transition in driving these improvements, while heterogeneity analysis indicates varying effects across different city types. Spatial spillover analysis further demonstrates that policy impacts extend beyond targeted cities, contributing to broader regional gains in UEP. These findings offer important insights for the design of integrated energy and environmental policies and support progress toward key Sustainable Development Goals (SDG 7, SDG 11, and SDG 12). Full article
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18 pages, 6409 KiB  
Article
MICP-Treated Coral Aggregate and Its Application in Marine Concrete
by Rui Xu, Baiyu Li, Xiaokang Liu, Ben Peng, Guanghua Lu, Changsheng Yue and Lei Zhang
Materials 2025, 18(15), 3619; https://doi.org/10.3390/ma18153619 (registering DOI) - 1 Aug 2025
Viewed by 151
Abstract
In marine engineering applications, substituting conventional crushed stone coarse aggregates with coral aggregates offers dual advantages: reduced terrestrial quarrying operations and minimized construction material transportation costs. However, the inherent characteristics of coral aggregates—low bulk density, high porosity, and elevated water absorption capacity—adversely influence [...] Read more.
In marine engineering applications, substituting conventional crushed stone coarse aggregates with coral aggregates offers dual advantages: reduced terrestrial quarrying operations and minimized construction material transportation costs. However, the inherent characteristics of coral aggregates—low bulk density, high porosity, and elevated water absorption capacity—adversely influence concrete workability and mechanical performance. To address these limitations, this investigation employed microbial-induced carbonate precipitation (MICP) for aggregate modification. The experimental design systematically evaluated the impacts of substrate concentration (1 mol/L) and mineralization period (14 days) on three critical parameters, mass gain percentage, water absorption reduction, and apparent density enhancement, across distinct particle size fractions (4.75–9.5 mm, 9.5–20 mm) and density classifications. Subsequent application trials assessed the performance of MICP-treated aggregates in marine concrete formulations. Results indicated that under a substrate concentration of 1 mol/L and mineralization period of 14 days, lightweight coral aggregates and coral aggregates within the 4.75–9.5 mm size fraction exhibited favorable modification effects. Specifically, their mass gain rates reached 11.75% and 11.22%, respectively, while their water absorption rates decreased by 32.22% and 34.75%, respectively. Apparent density increased from initial values of 1764 kg/m3 and 1930 kg/m3 to 2050 kg/m3 and 2207 kg/m3. Concrete mixtures incorporating modified aggregates exhibited enhanced workability and strength improvement at all curing ages. The 28-day compressive strengths reached 62.1 MPa (11.69% increment), 46.2 MPa (6.94% increment), and 60.1 MPa (14.91% increment) for the 4.75–9.5 mm, 9.5–20 mm, and continuous grading groups, respectively, compared to untreated counterparts. Full article
(This article belongs to the Section Construction and Building Materials)
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26 pages, 1337 KiB  
Article
Design of Logistics Platform Business Models in the View of Value Co-Creation
by Ke Huang, Fang Wang and Jie Bai
Systems 2025, 13(8), 640; https://doi.org/10.3390/systems13080640 (registering DOI) - 1 Aug 2025
Viewed by 139
Abstract
The effective design of logistics platform business models is an important means for platform-type logistics enterprises to gain a competitive advantage. This study employs RRS Logistics as a case study to clarify the dynamic environmental mechanisms of logistics platform business models from the [...] Read more.
The effective design of logistics platform business models is an important means for platform-type logistics enterprises to gain a competitive advantage. This study employs RRS Logistics as a case study to clarify the dynamic environmental mechanisms of logistics platform business models from the perspective of value co-creation and build a novel structural framework for logistics platform business models with community at their core. The research findings are as follows: First, guided by the idea of “value positioning–value co–creation–value support–value maintenance–value capture”, the conceptual framework of business models is redefined. The key steps in designing logistics platform business models, which can provide guidance and assistance for different logistics platforms, are proposed. Second, the design process for logistics platform business models should be dynamically adjusted in real time according to changes and environmental uncertainty. Third, in the process of transitioning to an ecological platform, logistics platforms’ ecosystem service clusters and ecosystem envelope are key factors in achieving a win–win scenario for all the stakeholders in the community. The case studies show that in logistics platform business model design, methods and key steps based on value co-creation could enhance the core competitiveness of logistics platforms. Full article
(This article belongs to the Section Supply Chain Management)
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36 pages, 17913 KiB  
Article
Manufacturing, Microstructure, and Mechanics of 316L SS Biomaterials by Laser Powder Bed Fusion
by Zhizhou Zhang, Paul Mativenga and Shi-Qing Huang
J. Funct. Biomater. 2025, 16(8), 280; https://doi.org/10.3390/jfb16080280 (registering DOI) - 31 Jul 2025
Viewed by 110
Abstract
Laser powder bed fusion (LPBF) is an advanced additive manufacturing technology that is gaining increasing interest for biomedical implants because it can produce dense, patient-specific metallic components with controlled microstructures. This study investigated the LPBF fabrication of 316L stainless steel, which is widely [...] Read more.
Laser powder bed fusion (LPBF) is an advanced additive manufacturing technology that is gaining increasing interest for biomedical implants because it can produce dense, patient-specific metallic components with controlled microstructures. This study investigated the LPBF fabrication of 316L stainless steel, which is widely used in orthopedic and dental implants, and examined the effects of laser power and scanning speed on the microstructure and mechanical properties relevant to biomedical applications. The study achieved 99.97% density and refined columnar and cellular austenitic grains, with optimized molten pool morphology. The optimal LPBF parameters, 190 W laser power and 700 mm/s, produced a tensile strength of 762.83 MPa and hardness of 253.07 HV0.2, which exceeded the values of conventional cast 316L stainless steel. These results demonstrated the potential of optimized LPBF 316L stainless steel for functional biomedical applications that require high mechanical integrity and biocompatibility. Full article
(This article belongs to the Special Issue Bio-Additive Manufacturing in Materials Science)
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17 pages, 960 KiB  
Article
Medium-Frequency Neuromuscular Electrical Stimulation in Critically Ill Patients Promoted Larger Functional Capacity Improvement During Recovery than Low-Frequency Neuromuscular Electrical Stimulation: Randomized Clinical Trial
by Pablo Guerra-Vega, Rodrigo Guzmán, Claudio Betancourt, Mario Grage, Cristian Vera, Macarena Artigas-Arias, Rodrigo Muñoz-Cofré, Kaio F. Vitzel and Gabriel Nasri Marzuca-Nassr
J. Clin. Med. 2025, 14(15), 5407; https://doi.org/10.3390/jcm14155407 (registering DOI) - 31 Jul 2025
Viewed by 155
Abstract
Background/Objectives: This study aimed to compare the effects of low- and medium-frequency NMES, combined with a standard physical therapy (SPT) program, on functional capacity in critically ill patients. Methods: Fifty-four critically ill patients admitted into Intensive Care Unit (ICU) and on mechanical ventilation [...] Read more.
Background/Objectives: This study aimed to compare the effects of low- and medium-frequency NMES, combined with a standard physical therapy (SPT) program, on functional capacity in critically ill patients. Methods: Fifty-four critically ill patients admitted into Intensive Care Unit (ICU) and on mechanical ventilation participated in this randomized, single-blinded, experimental study. Participants were randomly assigned to a Control group, who received a lower limb SPT program; the Low-frequency NMES group received lower limb SPT + NMES at 100 Hz; and the Medium-frequency NMES group received lower limb SPT + NMES at 100 Hz with a carrier frequency of 2500 Hz. The outcomes, encompassing functional capacity in the hospital, included muscle strength, handgrip strength, functional status, degree of independence for activities of daily living, functional and dynamic mobility, quality of life, and total days hospitalized. Results: Both NMES protocols combined with SPT improved functional capacity compared to the control group. Medium-frequency NMES provided additional benefits on dynamic balance, in the degree of independence to perform activities of daily living and quality of life (all p < 0.001) prior to hospital discharge. It also promoted larger gains on functional status prior to ICU discharge and on knee extension strength (both p < 0.05) prior to intermediate care unit discharge. Medium-frequency NMES also enhanced handgrip strength earlier than low-frequency NMES when compared to the control group. Notably, medium-frequency NMES was the only intervention associated with a significant reduction in total hospital stay duration (p < 0.05). Conclusions: Medium-frequency NMES, along with an SPT program in critically ill patients, showed greater benefits on functional capacity during recovery than low-frequency NMES. (Trial registration: This trial is registered on ClinicalTrials.gov: NCT05287919). Implications for rehabilitation: 1. Medium-frequency NMES may enhance physical functionality and quality of life in critically ill patients with ICU-acquired weakness. 2. Medium-frequency NMES can reduce the number of hospitalization days. 3. NMES combined with SPT represents a feasible and effective option for patients unable to engage in active rehabilitation during critical illness. Full article
(This article belongs to the Section Clinical Neurology)
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10 pages, 1555 KiB  
Article
Lithium-Decorated C26 Fullerene in DFT Investigation: Tuning Electronic Structures for Enhanced Hydrogen Storage
by Jiangang Yu, Lili Liu, Quansheng Li, Zhidong Xu, Yujia Shi and Cheng Lei
Molecules 2025, 30(15), 3223; https://doi.org/10.3390/molecules30153223 (registering DOI) - 31 Jul 2025
Viewed by 161
Abstract
Hydrogen energy holds immense potential to address the global energy crisis and environmental challenges. However, its large-scale application is severely hindered by the lack of efficient hydrogen storage materials. This study systematically investigates the H2 adsorption properties of intrinsic C26 fullerene [...] Read more.
Hydrogen energy holds immense potential to address the global energy crisis and environmental challenges. However, its large-scale application is severely hindered by the lack of efficient hydrogen storage materials. This study systematically investigates the H2 adsorption properties of intrinsic C26 fullerene and Li-decorated C26 fullerene using density functional theory (DFT) calculations. The results reveal that Li atoms preferentially bind to the H5-5 site of C26, driven by significant electron transfer (0.90 |e|) from Li to C26. This electron redistribution modulates the electronic structure of C26, as evidenced by projected density of states (PDOS) analysis, where the p orbitals of C atoms near the Fermi level undergo hybridization with Li orbitals, enhancing the electrostatic environment for H2 adsorption. For Li-decorated C26, the average adsorption energy and consecutive adsorption energy decrease as more H2 molecules are adsorbed, indicating a gradual weakening of adsorption strength and signifying a saturation limit of three H2 molecules. Charge density difference and PDOS analyses further demonstrate that H2 adsorption induces synergistic electron transfer from both Li (0.89 |e| loss) and H2 (0.01 |e| loss) to C26 (0.90 |e| gain), with orbital hybridization between H s orbitals, C p orbitals, and Li orbitals stabilizing the adsorbed system. This study aimed to provide a comprehensive understanding of the microscopic mechanism underlying Li-enhanced H2 adsorption on C26 fullerene and offer insights into the rational design of metal-decorated fullerene-based systems for efficient hydrogen storage. Full article
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28 pages, 1804 KiB  
Article
The Penetration of Digital Currency for Sustainable and Inclusive Urban Development: Evidence from China’s e-CNY Pilot Using SDID-SCM
by Ying Chen and Ke Zhang
Sustainability 2025, 17(15), 6981; https://doi.org/10.3390/su17156981 (registering DOI) - 31 Jul 2025
Viewed by 113
Abstract
Against the backdrop of China’s fast-growing digital economy and its financial inclusion agenda, there is still little city-level evidence on whether the e-CNY pilot accelerates financial deepening at the grassroots. Using a balanced panel of 271 prefecture-and-above cities for 2016–2022, this study employs [...] Read more.
Against the backdrop of China’s fast-growing digital economy and its financial inclusion agenda, there is still little city-level evidence on whether the e-CNY pilot accelerates financial deepening at the grassroots. Using a balanced panel of 271 prefecture-and-above cities for 2016–2022, this study employs a staggered difference-in-differences (SDID) design augmented by the synthetic control method (SCM) to rigorously identify the policy effect of the e-CNY pilot. The results show that the pilot program significantly improves urban financial inclusion, contributing to more equitable access to financial services and supporting inclusive socio-economic development. Mechanism analysis suggests that the effect operates mainly through two channels, a merchant-coverage channel and a transaction-scale channel, with the former contributing the majority of the overall effect. Incorporating a migration-based mobility index shows that most studies’ focus on the merchant-coverage effect is amplified in cities under tight mobility restrictions but wanes where commercial networks are already saturated, whereas the transaction-scale channel is largely insensitive to mobility shocks. Heterogeneity tests further indicate stronger gains in non-provincial capital cities and in the eastern and central regions. Overall, the study uncovers a “penetration-inclusion” network logic and provides policy insights for advancing sustainable financial inclusion through optimized terminal deployment, merchant incentives, and diversified scenario design. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
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