Next Article in Journal
JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance
Previous Article in Journal
The Antitumor Role of Incomptine A in a Breast Cancer Murine Model: Impairment of Hexokinase II Expression and Apoptosis Induction
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 14
Issue 15
10.3390/cells14151193
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA

by
Andrea Bayona-Hernandez
1,
Ana Miladinović
2,
Ludovica Antiga
2,
Pavel Hozak
2,
Martin Sztacho
3 and
Enrique Castano
1,*
1
Unidad de Biologia Integrativa, Centro de Investigación Científica de Yucatán, A.C., Mérida 97205, Yucatan, Mexico
2
Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic
3
Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Cells 2025, 14(15), 1193; https://doi.org/10.3390/cells14151193 (registering DOI)
Submission received: 9 July 2025 / Revised: 26 July 2025 / Accepted: 30 July 2025 / Published: 2 August 2025
(This article belongs to the Section Cell Microenvironment)
Review Reports Versions Notes

Abstract

Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area. Both lipids and lncRNAs play central roles in cellular regulation, and growing evidence reveals a complex interplay between these molecules. These interactions contribute to key biological functions, such as cancer progression, lipid droplet transport, autophagy, liquid−liquid phase separation, and the formation of organelles without membranes. Understanding the lipid−lncRNA interface opens new avenues for unraveling cellular regulation and disease mechanisms, holding great potential not only for elucidating the fundamental aspects of cellular biology but also for identifying innovative therapeutic targets for metabolic disorders and cancer. This review highlights the biological relevance of lipid–lncRNA interactions by exploring their roles in cellular organization, regulation, and diseases, including metabolic and cancer-related disorders.
Keywords: lncRNA; phospholipids; phase separation lncRNA; phospholipids; phase separation

Share and Cite

MDPI and ACS Style

Bayona-Hernandez, A.; Miladinović, A.; Antiga, L.; Hozak, P.; Sztacho, M.; Castano, E. Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA. Cells 2025, 14, 1193. https://doi.org/10.3390/cells14151193

AMA Style

Bayona-Hernandez A, Miladinović A, Antiga L, Hozak P, Sztacho M, Castano E. Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA. Cells. 2025; 14(15):1193. https://doi.org/10.3390/cells14151193

Chicago/Turabian Style

Bayona-Hernandez, Andrea, Ana Miladinović, Ludovica Antiga, Pavel Hozak, Martin Sztacho, and Enrique Castano. 2025. "Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA" Cells 14, no. 15: 1193. https://doi.org/10.3390/cells14151193

APA Style

Bayona-Hernandez, A., Miladinović, A., Antiga, L., Hozak, P., Sztacho, M., & Castano, E. (2025). Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA. Cells, 14(15), 1193. https://doi.org/10.3390/cells14151193

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop