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Feature Paper
Article

4 Citations

3,108 Views

21 Pages

Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems

Huan Yu,
Yanfei Zhang,
Yinghui Ma,
Huifeng Zhang and ,
Chengyi Hao,
Yong Zhang,
Zhengqiang Li,
Xianrong Qi and
Nianqiu Shi
+ 4 authors+ 0 author

Pharmaceutics2022, 14(4), 765;https://doi.org/10.3390/pharmaceutics14040765

31 March 2022

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs gene...

(This article belongs to the Section Drug Delivery and Controlled Release)

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Article

6 Citations

3,024 Views

24 Pages

Tailored Supersaturable Immediate Release Behaviors of Hypotensive Supersaturating Drug-Delivery Systems Combined with Hot-Melt Extrusion Technique and Self-Micellizing Polymer

Huan Yu,
Yinghui Ma,
Yanfei Zhang,
Huifeng Zhang and ,
Lili Zuo,
Chengyi Hao,
Weilun Yu,
Xiaoying Lin,
Yong Zhang and
Nianqiu Shi
+ 6 authors+ 1 author

Polymers2022, 14(22), 4800;https://doi.org/10.3390/polym14224800

8 November 2022

The short-term immediate release of supersaturated drug-delivery systems (SDDSs) presents an interesting process that can be tailored to multi-stage release events including initial release after dosing and dissolution, evolved release over longer di...

(This article belongs to the Special Issue Advanced Properties in Amorphous Polymers)

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