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Article

8 Citations

2,665 Views

12 Pages

Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine

Alexey Noev,
Natalia Morozova,
Nikita Suvorov,
Yuriy Vasil’ev and ,
Andrei Pankratov and
Mikhail Grin
+ 1 author+ 0 author

Pharmaceuticals2023, 16(10), 1398;https://doi.org/10.3390/ph16101398

2 October 2023

The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body. A possible way to increase the selectivity of the acti...

(This article belongs to the Section Pharmaceutical Technology)

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Article

3 Citations

2,046 Views

27 Pages

Structure–Property Relationships in Novel Series of Photoswitchable Local Anesthetic Ethercaine Derivatives: Emphasis on Biological and Photophysical Properties

Alexey Noev,
Daria Likhobabina,
Janna Sutemieva,
Anna Plyutinskaya and ,
Dmitry Cheshkov,
Natalia Morozova,
Aleksandra Vinokurova,
Yuriy Vasil’ev,
Nikita Suvorov and
Mikhail Grin
+ 10 authors+ 5 authors

Int. J. Mol. Sci.2025, 26(7), 3244;https://doi.org/10.3390/ijms26073244

31 March 2025

The insufficient selectivity of existing local anesthetics can lead to serious adverse effects. Considering the widespread use of this class of drugs, the development of new local anesthetics that do not cause side effects is an important task. One a...

(This article belongs to the Special Issue Ion Channels as Therapeutic Target: Drug Design and Pharmacological Investigation 2.0)

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Article

15 Citations

5,106 Views

16 Pages

A Novel Photoswitchable Azobenzene-Containing Local Anesthetic Ethercaine with Light-Controlled Biological Activity In Vivo

Alexey Noev,
Nikita Kuznetsov,
Georgiy Korenev,
Natalia Morozova and ,
Yuriy Vasil’ev,
Nikita Suvorov,
Ekaterina Diachkova,
Maksim Usachev,
Andrei Pankratov and
Mikhail Grin
+ 5 authors+ 0 author

Int. J. Mol. Sci.2022, 23(10), 5352;https://doi.org/10.3390/ijms23105352

11 May 2022

Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity p...

(This article belongs to the Special Issue Advances in Photopharmacology)

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