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Review

9 Citations

5,291 Views

19 Pages

Dextro-Transposition of Great Arteries and Neurodevelopmental Outcomes: A Review of the Literature

Kalliopi Kordopati-Zilou,
Theodoros Sergentanis,
Panagiota Pervanidou,
Danai Sofianou-Petraki,
Konstantinos Panoulis,
Nikolaos Vlahos and
Makarios Eleftheriades

Children2022, 9(4), 502;https://doi.org/10.3390/children9040502

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2 April 2022

Background: Arterial switch operation (ASO) is the gold-standard surgical approach for dextro-transposition of the great arteries (D-TGA). It is performed during the neonatal period and has almost diminished the previously high mortality rate (from 9...

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Article

3 Citations

2,870 Views

13 Pages

Long-Term Outcomes After Arterial Switch Operation for dextro-Transposition of the Great Arteries—30-Year Single-Center Experience

Johanna Schlein,
Clemens Ungerböck,
Daniela Tertschnig,
Alexandra Kaider,
Barbara Karner,
Clemens Atteneder,
Erhan Urganci,
Paul Werner,
Eva Base and
Daniel Zimpfer

J. Clin. Med.2025, 14(9), 3160;https://doi.org/10.3390/jcm14093160

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2 May 2025

Background/Objectives: The arterial switch operation (ASO) has been performed in the neonatal period as an anatomical correction for d-transposition of the great arteries since the 1980s. As the population of adult congenital heart disease patients g...

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Review

5 Citations

11,149 Views

39 Pages

Pathogenesis and Surgical Treatment of Dextro-Transposition of the Great Arteries (D-TGA): Part II

Marek Zubrzycki,
Rene Schramm,
Angelika Costard-Jäckle,
Michiel Morshuis,
Jan F. Gummert and
Maria Zubrzycka

J. Clin. Med.2024, 13(16), 4823;https://doi.org/10.3390/jcm13164823

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15 August 2024

Dextro-transposition of the great arteries (D-TGA) is the second most common cyanotic heart disease, accounting for 5–7% of all congenital heart defects (CHDs). It is characterized by ventriculoarterial (VA) connection discordance, atrioventric...

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Article

954 Views

20 Pages

Evaluation of Operated Dextro-Transposition of Great Arteries Patients in Follow-Up: Comparison of Transthoracic Echocardiography and Cardiac CT Angiography

Ali Nazım Güzelbağ,
İsa Özyılmaz,
Demet Kangel,
Osman Nuri Bayrak,
Hatice Dilek Özcanoğlu,
Behzat Tüzün,
Ali Can Hatemi,
Erkut Öztürk and
Serap Baş

Diagnostics2025, 15(19), 2419;https://doi.org/10.3390/diagnostics15192419

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23 September 2025

Background: Arterial switch operation (ASO) is the standard surgical treatment for dextro-transposition of great arteries (d-TGA). Long-term complications affecting pulmonary arteries, coronary arteries, and aortic root necessitate detailed surveilla...

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Article

4 Citations

2,602 Views

9 Pages

Left Atrial Volumetric and Deformation Analysis in Adult Patients with Dextro-Transposition of the Great Arteries (Insights from the CSONGRAD Registry and MAGYAR-Path Study)

Attila Nemes,
Gergely Rácz,
Árpád Kormányos,
Péter Domsik,
Anita Kalapos,
Nándor Gyenes,
Nóra Ambrus,
Gábor Bogáts,
István Hartyánszky and
Kálmán Havasi

J. Clin. Med.2020, 9(2), 463;https://doi.org/10.3390/jcm9020463

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7 February 2020

Background: In complete or dextro-transposition of the great arteries (dTGA), the aorta and the pulmonary artery are transposed. The present study was designed to examine dTGA-associated left atrial (LA) volumetric and functional abnormalities in adu...

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Article

2 Citations

3,653 Views

18 Pages

Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries

Manuela Cucerea,
Maria-Livia Ognean,
Alin-Constantin Pinzariu,
Marta Simon,
Laura Mihaela Suciu,
Dana-Valentina Ghiga,
Elena Moldovan and
Mihaela Moscalu

Biomedicines2024, 12(9), 2018;https://doi.org/10.3390/biomedicines12092018

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4 September 2024

Dextro-transposition of the great arteries (D-TGA) is a critical congenital heart defect that can impact neurodevelopment due to cerebral perfusion and oxygenation disorders followed by alterations in synaptogenesis, gyrification, sulcation, and the...

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Article

5 Citations

4,473 Views

15 Pages

High-Throughput Genomics Identify Novel FBN1/2 Variants in Severe Neonatal Marfan Syndrome and Congenital Heart Defects

Gloria K. E. Zodanu,
John H. Hwang,
Zubin Mehta,
Carlos Sisniega,
Alexander Barsegian,
Xuedong Kang,
Reshma Biniwale,
Ming-Sing Si,
Gary M. Satou and
Marlin Touma
+ 4 authors

Int. J. Mol. Sci.2024, 25(10), 5469;https://doi.org/10.3390/ijms25105469

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17 May 2024

Fibrillin-1 and fibrillin-2, encoded by FBN1 and FBN2, respectively, play significant roles in elastic fiber assembly, with pathogenic variants causing a diverse group of connective tissue disorders such as Marfan syndrome (MFS) and congenital contra...

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Opinion

1,591 Views

7 Pages

Prenatal Alcohol Exposure and Congenital Heart Defects: Retinoic Acid Deficiency as a Potential Mechanism in Dextro-Type Transposition of the Great Arteries

Roberto Paparella,
Carolina Putotto,
Marco Fiore,
Fiorenza Colloridi,
Paolo Versacci,
Mauro Ceccanti,
Bruno Marino and
Luigi Tarani

Pathophysiology2025, 32(3), 35;https://doi.org/10.3390/pathophysiology32030035

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10 July 2025

Fetal alcohol spectrum disorder (FASD) is a preventable cause of developmental disabilities linked to prenatal alcohol exposure (PAE). Congenital heart defects (CHDs) are frequently observed in FASD, with a notable association between PAE and dextro-...

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Article

4 Citations

3,604 Views

15 Pages

Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells

Imelda Ontoria-Oviedo,
Gabor Földes,
Sandra Tejedor,
Joaquín Panadero,
Tomoya Kitani,
Alejandro Vázquez,
Joseph C. Wu,
Sian E. Harding and
Pilar Sepúlveda

Int. J. Mol. Sci.2021, 22(24), 13270;https://doi.org/10.3390/ijms222413270

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9 December 2021

The dextro-transposition of the great arteries (d-TGA) is one of the most common congenital heart diseases. To identify biological processes that could be related to the development of d-TGA, we established induced pluripotent stem cell (iPSC) lines...

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Article

6 Citations

2,623 Views

10 Pages

Early Cerebrovascular Autoregulation in Neonates with Congenital Heart Disease

Celina L. Brunsch,
Mirthe J. Mebius,
Rolf M. F. Berger,
Arend F. Bos and
Elisabeth M. W. Kooi

Children2022, 9(11), 1686;https://doi.org/10.3390/children9111686

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3 November 2022

Neonates with congenital heart disease (CHD) display delayed brain development, predisposing them to impaired cerebrovascular autoregulation (CAR) and ischemic brain injury. For this paper, we analyzed the percentage of time with impaired CAR (%time...

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10 Results Found

Dextro-Transposition of Great Arteries and Neurodevelopmental Outcomes: A Review of the Literature

Long-Term Outcomes After Arterial Switch Operation for dextro-Transposition of the Great Arteries—30-Year Single-Center Experience

Pathogenesis and Surgical Treatment of Dextro-Transposition of the Great Arteries (D-TGA): Part II

Evaluation of Operated Dextro-Transposition of Great Arteries Patients in Follow-Up: Comparison of Transthoracic Echocardiography and Cardiac CT Angiography

Left Atrial Volumetric and Deformation Analysis in Adult Patients with Dextro-Transposition of the Great Arteries (Insights from the CSONGRAD Registry and MAGYAR-Path Study)

Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries

High-Throughput Genomics Identify Novel FBN1/2 Variants in Severe Neonatal Marfan Syndrome and Congenital Heart Defects

Prenatal Alcohol Exposure and Congenital Heart Defects: Retinoic Acid Deficiency as a Potential Mechanism in Dextro-Type Transposition of the Great Arteries

Modeling Transposition of the Great Arteries with Patient-Specific Induced Pluripotent Stem Cells

Early Cerebrovascular Autoregulation in Neonates with Congenital Heart Disease