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Article

15 Citations

5,214 Views

21 Pages

Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney

Paul E. Squires,
Gareth W. Price,
Ulrik Mouritzen,
Joe A. Potter and ,
Bethany M. Williams and
Claire E. Hills
+ 1 author+ 0 author

Int. J. Mol. Sci.2021, 22(6), 2809;https://doi.org/10.3390/ijms22062809

10 March 2021

Chronic kidney disease (CKD) is a global health problem associated with a number of comorbidities. Recent evidence implicates increased hemichannel-mediated release of adenosine triphosphate (ATP) in the progression of tubulointerstitial fibrosis, th...

(This article belongs to the Special Issue Therapeutic Potential of Targeting Connexins in Managing Disease Onset and Progression)

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Article

23 Citations

5,401 Views

12 Pages

Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice

Moises Freitas-Andrade,
John Bechberger,
Jasmine Wang,
Ken K.C. Yeung and ,
Shawn N. Whitehead,
Rie Shultz Hansen and
Christian C. Naus
+ 2 authors+ 0 author

Biomolecules2020, 10(3), 353;https://doi.org/10.3390/biom10030353

26 February 2020

Ischemic stroke is a complex and devastating event characterized by cell death resulting from a transient or permanent arterial occlusion. Astrocytic connexin43 (Cx43) gap junction (GJ) proteins have been reported to impact neuronal survival in ische...

(This article belongs to the Special Issue Connexins, Innexins, and Pannexins: From Biology to Clinical Targets)

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