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Keywords = cyclazine

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34 pages, 9851 KB  
Review
Indolizines and Their Hetero/Benzo Derivatives in Reactions of [8+2] Cycloaddition
by Eugene V. Babaev and Ivan A. Shadrin
Molecules 2021, 26(7), 2050; https://doi.org/10.3390/molecules26072050 - 3 Apr 2021
Cited by 9 | Viewed by 6156
Abstract
Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. [...] Read more.
Peculiarities of [8+2] cycloaddition of acetylenes to indolizines are reviewed. Especially mentioned are indolizines with leaving groups at positions 3 and 5. Cycloaddition to aza- and benzo derivatives are reviewed, as well as 1,10-cyclizations and processes leading to cyclazines where indolizines are intermediates. Mechanistic features (adducts and cycloadducts) and theoretical aspects (one- or two-steps mechanism) are reviewed. Full article
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