Search Results (199)

Several studies have investigated counterflow and concurrent flow in channels separated by a membrane to simulate mass transfer through membranes; however, few of them have used computational fluid dynamics (CFD). The current study aimed to numerically simulate and physically describe the distribution of pressure and velocity in counter-current flow by solving Navier-Stokes (N-S) equations in the channel and membrane pores (vertical channels). This is in contrast to most previous studies, in which the channel flow was simulated using N-S equations while ultra-filtration membrane flow was simulated using Darcy’s law. Consequently, the current study was executed using a CFD simulation to achieve several significant features: avoiding the execution of experimental tests, reducing the effort of model design and the expense and time consumption of fabrication, and facilitating the easy observation of variations in the pressure and the horizontal and vertical velocity for each point in the model. Two-dimensional CFD methods directly simulated the flow in channels and membrane pores to solve the N-S equations for each point in the whole domain, for which the velocity (horizontal and vertical) and pressure were calculated. In the current study, it was found that the pressure decreased from the inlet to the outlet of the channel, the horizontal velocity decreased from the inlet to the middle of the channel length and then increased to the outlet of the channel, and the vertical velocity decreased from the inlet to the middle of the channel length (L/2) with an upward direction (positive) and from L/2 to the outlet of the channel with a downward direction (negative). The analytical solution (1D model) was used to validate a numerical simulation (CFD) for the current study, but there were slight differences in the results between them. The results were perfectly explored and displayed the flow distribution patterns inside the channels and the membrane pores (vertical channels). The current study model represents the hemodialysis process. Full article

This work presents the development and validation of a 1D finite-volume model for the simulation of planar solid oxide cells (SOCs), developed for integration in more complex systems and process simulations. The model allows to investigate the temperature, composition, and current density profiles along the channel. In this work, the Fick’s equations typically used to calculate the concentration overpotential due to H₂ and H₂O diffusion in the electrode are improved compared to 1D SOC models available in the literature. In particular, the approximate analytical solution of the dusty gas model (DGM) equations allows for a better definition of H₂ and H₂O mixture diffusion coefficients, which are relevant, for instance, in the case of solid oxide fuel cells (SOFCs) fed with reformate gas mixtures. Differently from other 1D models available in the literature, the model developed is validated using experimental SOFC polarization curves covering a wide range of operating conditions in terms of molar fraction of H₂ (21–93%) and H₂O (7–50%) in the fuel, temperature (550–750 °C), and fuel utilization factor (exceeding 90%), demonstrating that 1D SOC models retain a good description of the physical processes occurring within the cell. While this work focuses on a co-flow SOFC configuration, the model can simulate a counter-flow configuration and electrolysis operation without modifying the model equations. Full article

Countercurrent electrophoresis (CCEP) is a technology that forms a steady focus in the separation channel through the coupling of electric field migration and reverse fluid flow, so as to realize the synchronous concentration and separation of substances. This paper reviews the evolution of CCEP from its theoretical origin, device design to microfluidic integration and optimization. Compared with traditional capillary electrophoresis, CCEP has higher processing flux, continuous operation ability and separation resolution, and has been successfully applied to isotope enrichment, protein recovery and complex matrix analysis. This paper further discusses the methods derived from it, such as isoelectric focusing (CACE), conductance gradient focusing (CGF) and electric field gradient focusing (EFGF), which expand the analysis ability and application scenarios of CCEP. Although the technology still faces challenges such as system stability, operation complexity and detection dependence, with the development of microfluidic, intelligent control and new material technology, CCEP shows broad development prospects in biomedicine, environmental monitoring and nuclide separation. Full article

We investigate the flow over a breached dam through combined measurements and numerical simulations, revealing key topological features of the mean flow, including separation and stagnation surfaces, attached vortices, secondary currents, and boundary layer development. PIV measurements of velocities are complemented with simulations with the interFoam solver of OpenFOAM-v2106 (URANS with k-ω SST closure model and rough-wall corrections). We show the development of the boundary layer over the crest, influenced by the breach crest wall curvature and strong lateral flow convergence. Three-dimensional separation is observed in the plunging pool. Two different attached vortices develop along the bottom and side walls of the breach, where underscouring is known to be strong. The first is associated with an adverse pressure gradient while the second results from the flow curvature imposed by the evolving geometry of the plunging pool. A counter rotating vortex pair is observed in the flow exiting the dam breach channel. We discuss the significance of these structures for hydraulic erosion and underscouring. We also provide recommendations for CFD modeling of dam breaches. Full article

We use 29 years of altimeter-derived sea level anomalies and geostrophic velocities (1993–2021) from the Copernicus Marine Service to identify the Mexican Coastal Current (MCC) and to examine how it interacts with the coastline. Variance-ellipse and empirical orthogonal function analyses isolate a narrow alongshore jet with a mean width of about 95 km and average speeds near 0.3 m ${\mathrm{s}}^{-1}$ that reverses direction semiannually: poleward in June and July and equatorward in the rest of the year. When the MCC impinges on broad concavities in the coast, the boundary layer separates, forming recirculation cells that intensify and detach as coherent eddies. These near-shore eddies have similar radii (from ∼30 km) and relative vorticity of $\pm 0.5\times {10}^{-5}$${\mathrm{s}}^{-1}$ at the beginning of their generation, and they propagate offshore once the current weakens. A simple numerical model reproduces the observed behavior and suggests that eddy formation is controlled by flow separation rather than generic instability. The semiannual change in direction of the MCC indicate a link with the larger-scale North Equatorial Countercurrent and Costa Rica Coastal Current systems of the eastern tropical Pacific. Full article

A new DCMD module design that introduces an insulation barrier of negligible thickness to divide the open duct of the hot-saline feed into two subchannels for dual-flow operation was investigated. This configuration enables one subchannel to operate in a cocurrent-flow mode and the other in a countercurrent-flow recycling mode, thereby significantly enhancing the permeate flux. Theoretical and experimental investigations were conducted to develop modeling equations capable of predicting the permeate flux in DCMD modules. These studies demonstrated the technical feasibility of minimizing temperature polarization effects while improving flow characteristics to boost permeate flux. Results indicated that increasing both convective heat-transfer coefficients and residence time generally improved device performance. The dual-flow operation increased fluid velocity and extended residence time, leading to reduced heat-transfer resistance and enhanced heat-transfer efficiency. Theoretical predictions and experimental results consistently showed that the absorption flux improved by up to 40.77% under the double-flow operation with internal recycling configuration compared to a single-pass device of identical dimensions. The effects of inserting the insulation barrier on permeate flux enhancement, power consumption, and overall economic feasibility were also discussed. Full article

Lagrangian Coherent Structures (LCSs) in the mesoscale circulation of the Western Equatorial Atlantic (WEA), a region governed by the North Brazil Current (NBC) and its retroflection, are analyzed. Observations from 63 surface drifters deployed between 2018 and 2019 were combined with ocean analysis/forecast fields. The Finite-Time Lyapunov Exponent (FTLE) was computed using 15- and 90-day integrations to identify transport barriers and persistent structures. FTLE ridges showed strong seasonal correspondence with drifter trajectories, with 34–74% of drifter positions lying within 0.25° of attracting or repelling LCSs. Characteristic FTLE magnitudes reached ~0.3 d⁻¹, implying particle separation e-folding times of approximately 3.3 days. Spatial agreement between drifter-derived and model-based FTLE fields exhibited similar variability across seasons, with the highest correspondence during periods of intensified frontal activity. These results indicate that a substantial portion of the observed drifter motion follows or remains close to FTLE-defined pathways, supporting the robustness of the Lagrangian structures identified in the WEA. Overall, the study provides the first quantitative LCS-based characterization of mesoscale transport in this region, revealing recurrent eddies, instability zones, and flow boundaries associated with the NBC system and its interaction with the North Equatorial Countercurrent. Full article

Background: Human adenovirus type 4 (HAdV-4), the sole member of species Human mastadenovirus E (HAdV-E), is of zoonotic origin and has established stable human transmission through recombination, conferring distinctive host adaptation and pathogenicity. It causes respiratory and ocular diseases, with a significant risk of severe pneumonia in children. No targeted antivirals are approved for routine use, leaving supportive care as the primary management. China bears a relatively high HAdV-4 disease burden in Asia. Methods: To generate neutralizing nanobodies (Nbs) against HAdV-4, we employed an alpaca immunization strategy using hexon protein from Ad4-RI67 strain, followed by the isolation of hexon-specific nanobodies. The epitope competition and molecular docking was employed to analysis the binding site of the Nbs’. We engineered VHH-Fc fusions by conjugating VHH domains to human IgG1 Fc. The lead candidate, NVA17, showed efficacy in both in vitro and in vivo (Stat1^+/− mouse model). Flow cytometric analysis was employed to assess the downstream immune effects of NVA17 in vivo. Its intracellular neutralization mechanism was further investigated through confocal microscopy by examining co-localization in TRIM21-overexpressing and knockdown cells. Results: The isolated nanobodies revealed epitopes distinct from those targeted by known antibodies. The lead candidate NVA17 demonstrated potent neutralizing activity in vitro (IC₅₀ < 10 ng/mL). In the Stat1^+/− mouse model, NVA17 provided complete protection against lethal challenge, significantly reduced viral load in the lungs, and ameliorated pathological damage. NVA17 treatment dose-dependently reversed the virus-induced reduction in immune cell counts and enhanced cytotoxicity, suggesting a systemic immunomodulatory effect. Mechanistic studies indicated that the antiviral activity of NVA17 partly depends on the TRIM21-mediated antibody-dependent intracellular neutralization (ADIN) pathway, whereby TRIM21 terminates the viral life cycle by promoting viral degradation via K48-linked ubiquitination. Conclusions: We have identified multiple antibody candidates, particularly NVA17, with significant therapeutic potential for developing antibody-based treatments against HAdV-4. This offers a targeted intervention strategy to counter the current lack of specific antiviral therapies. Full article

As a zero-carbon fuel, ammonia holds significant potential for achieving the “dual carbon” strategic goals. However, its extremely low laminar burning velocity (LBV) limits its direct application in combustion systems. This work systematically reviews the research progress on the LBV of ammonia flames, focusing on three key aspects: measurement methods, effects of combustion conditions, and reaction kinetic models. In terms of measurement methods, the principles, applicability, and limitations of the spherical outwardly propagating flame method, Bunsen-burner method, counter-flow flame method, and heat flux method are discussed in detail. It is pointed out that the heat flux method and counter-flow flame method are more suitable for the accurate measurement of ammonia flame LBV due to their low stretch rate and high stability. Regarding the effects of combustion conditions, the LBV characteristics of pure ammonia flames under ambient temperature and pressure are summarized. The influence patterns of three factors on LBV are analyzed systematically: blending high-reactivity fuels (e.g., hydrogen and methane), oxygen-enriched conditions, and variations in temperature and pressure. This analysis reveals effective approaches to improve ammonia combustion performance. Furthermore, the promoting effect of high-reactivity fuel blending on liquid ammonia combustion was also summarized. For reaction kinetic models, various chemical reaction mechanisms applicable to pure ammonia and ammonia-blended fuels (ammonia/hydrogen, ammonia/methane, etc.) are sorted out. The performance and discrepancies of each model in predicting LBV are evaluated. It is noted that current models still have significant uncertainties under specific conditions, such as high pressure and moderate blending ratios. This review aims to provide theoretical references and data support for the fundamental research and engineering application of ammonia combustion, promoting the development and application of ammonia as a clean fuel. Full article

This study presents comprehensive experimental, analytical, and numerical analyses of heat transfer during countercurrent flow of Fluorinert FC-72 and distilled water within a multi-mini-channel (MMCH) module under steady-state conditions. The experimental investigation was conducted in a test section inclined at an angle of 165 degrees relative to the horizontal plane, utilizing an infrared camera to measure the external temperature of the heated mini-channel (MCH) wall. The test module comprised twelve MCHs: six hot (HMCH) and six cold mini-channels (CMCH), each with a rectangular cross-section. The dimensions of each MCH are 140 mm in length, 18.3 mm in width, and 1.5 mm in depth, with a hydraulic diameter of d_h = 2.77 mm. The heating system on the top wall of the external heated copper comprises a halogen heating lamp. Results include infrared thermographs, temperature distributions, and heat transfer coefficients (HTCs) along the channels. Local HTCs were calculated using a one-dimensional (1D) approach, a simple analytical method, at interfaces such as the heated plate—HMCHs, HMCHs—separating plate, separating plate—CMCHs, and CMCHs—closing plate. CFD simulations conducted with Simcenter STAR-CCM+ incorporated empirical data from experiments, using parameters like temperature, pressure, velocity profiles, and heat flux density to determine HTCs. The maximum difference between the 1D method and CFD results was 29% at the HMCHs/separating plate interface. In comparison, the minimum was 13.5% at the separating plate/CMCHs interface, with an average across all channels and heat flux densities. Full article

This study developed an automated multistage countercurrent extraction device and applied it to the separation and extraction of phenolic acids—including neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid A, isochlorogenic acid B, and isochlorogenic acid C—from an aqueous extract of Lonicera japonica Thunb. The extraction process was optimized by systematically evaluating critical parameters such as liquid–liquid equilibrium pH, internal diameter of the tee connector, phase flow rate ratio, and the number of extraction stages. The apparent partition coefficients of all six phenolic acids increased with decreasing aqueous pH, with fitted pKa values ranging from 3.7 to 4.3. A reduction in tee diameter (0.75 mm) was found to enhance mass transfer efficiency. Increasing the flowrate of both phases (20 mL/min), the organic-to-aqueous phase ratio (4:1), and the number of extraction stages (3 stages) significantly improved both stage efficiency and overall extraction yield. Under optimized conditions, the target chlorogenic acids were efficiently enriched, with their total content increasing from 50.3 mg/g to 70.1 mg/g in the solid residue after three countercurrent stages. The automated multistage countercurrent extraction system demonstrated robust performance, suggesting promising potential for applications in the preparation of traditional Chinese medicine ingredients or as an automated sample pretreatment method in analytical workflows. This study provides a novel and green technological solution for efficient separation of complex TCM systems. Full article

Collar structures are widely used to protect monopile foundations from scour, but their geometric obstruction hinders direct observation of the surrounding flow in physical experiments. To overcome this limitation, this study employs large-eddy simulation (LES) to investigate the flow characteristics around a monopile with collar protection. The LES model was validated against well-documented experimental data of pile-induced flow, confirming its reliability. Simulations under flat-bed and equilibrium scour conditions were conducted to evaluate the effects of the collar on time-averaged velocity, vortex dynamics, and turbulence intensity. The results show that the collar substantially weakens the upstream accelerated flow, suppresses horseshoe vortex formation, and reduces both the strength and extent of sidewall currents. Under flatbed conditions, the side-flow intensity decreases by 24.3% and the accelerated flow area is reduced by 93.3%. A counter-rotating vortex beneath the collar dissipates kinetic energy and simplifies the near-bed vortex system, thereby mitigating scour. However, the protective effect diminishes with increasing inflow velocity, with turbulence intensity rising by 159% for a 14% velocity increase. Overall, this study provides deeper insights into the protective mechanisms of collar structures, advancing the understanding of their effectiveness and limitations in monopile scour protection. Full article

Accurately simulating immiscible counter-current flow is crucial for applications from geological ${\mathrm{CO}}_2$ storage to shale gas production, yet it remains a major challenge for conventional pore network models (PNMs), which are unable to handle the numerical instability of opposing flows. To address this critical gap, we developed a novel dynamic PNM that incorporates a ‘transition state’ algorithm. This method successfully eliminates the spurious meniscus oscillations that hinder traditional models, enabling robust simulation of the complete counter-current process. Using this model, we quantify the profound impact of pore structure on flow efficiency. Our results demonstrate that increasing the pore size distribution uniformity (Weibull shape factor k from 0.5 to 3.0) extends the persistence of continuous air outflow pathways by more than six-fold (from 359 to over 2300 simulation steps). This leads to a quantifiable increase in the initial fluid exchange rate by nearly 10 times (from ${10}^{-11}$ to ${10}^{-10}$${\mathrm{m}}^3$/s) and a reduction in final residual air saturation by 53% (from 0.91 to 0.43). This work provides a tool for predicting and optimizing counter-current flow efficiency in subsurface engineering applications. Full article

Background/Objectives: Long-term obesity management consistently fails due to two major barriers: poor adherence, exacerbated by ultra-processed foods with addictive potential, and post-weight loss metabolic adaptation that reduces energy expenditure by approximately 500 kcal/day. Current paradigms—static diets and GLP-1 receptor agonists—address these barriers only partially. The objectives of this thesis-driven review are: (1) to conduct a focused evidence-mapping of Ketogenic–Mediterranean Diet (KMD) protocols; (2) to analyze why existing protocols have not explicitly countered metabolic adaptation; and (3) to present the Adaptive Ketogenic–Mediterranean Protocol (AKMP). Methods: Hybrid methodology—an argumentative narrative review anchored by a structured evidence-mapping search (PRISMA-style flow for transparency). Results: We identified 29 studies implementing KMD protocols with significant weight loss and superior adherence. However, none of the published protocols explicitly implement anti-adaptive strategies, despite an estimated ketogenic metabolic advantage (≈100–300 kcal/day), context-dependent and more consistently observed in longer trials and during weight-maintenance settings. Conclusions: Unlike GLP-1 receptor agonists—which primarily suppress appetite, require ongoing pharmacotherapy, and do not directly mitigate the decline in energy expenditure—the AKMP couples a Mediterranean foundation for adherence with a ketogenic metabolic advantage and a biomarker-guided adjustment system explicitly designed to counter metabolic adaptation, aiming to improve the durability of weight loss and patient self-management. As a theoretical construct, the AKMP requires confirmation in prospective, controlled studies; accordingly, we outline a pragmatic 24-week pilot design in “Pragmatic Pilot Trial to Validate the AKMP–Incretin Sequencing”. Full article

Addressing the technological bottlenecks in the efficient utilization of clay-type Li deposits in China, this study systematically investigates Li occurrence states and develops clean extraction processes using the Jinyinshan clay-type Li deposit in southern Hubei as a case study. The research aims to provide technical guidance for subsequent geological exploration and development of such deposits. Analytical techniques, including AMICS, EPMA, and LA-ICP-MS, reveal that Li primarily occurs in structurally bound forms within cookeite (82.55% of total Li), illite (6.65%), and rectorite (5.20%), with mineral particle sizes concentrated in fine-grained fractions (<45 μm). Leveraging process mineralogical insights, two industrially adaptable blank roasting–acid leaching processes were innovatively developed. Process I employs a full flow of blank roasting–hydrochloric acid leaching–Li-Al separation–Ca/Mg removal–concentration for Li precipitation–three-stage counter-current washing. Optimizing roasting temperature (600 °C), hydrochloric acid concentration (18 wt%), and leaching parameters achieved a 92.37% Li leaching rate. Multi-step purification yielded lithium carbonate with >99% Li₂CO₃ purity and an overall Li recovery of 73.89%. Process II follows blank roasting–sulfuric acid leaching–Al removal via alum precipitation–Al/Fe removal–freeze crystallization for sodium sulfate removal–Ca/Mg removal–concentration for Li precipitation–three-stage counter-current washing. Parameter optimization and freezing impurity removal achieved an 89.11% Li leaching rate, producing lithium carbonate with >98.85% Li₂CO₃ content alongside by-products like crude sodium chloride and ammonium alum. Both processes enable resource utilization of Al-rich residues, with the hydrochloric acid-based method excelling in stability and the sulfuric acid-based approach offering superior by-product valorization potential. This low-energy, high-yield clean extraction system provides critical theoretical and technical foundations for scaling clay-type Li deposit utilization, advancing green Li extraction and industrial chain development. Full article