Search Results (31)

Prostate cancer (PCa) is one of the leading causes of cancer-related morbidity and mortality in men worldwide, and early detection remains crucial for ensuring effective treatment and improving patient outcomes. In this context, the development of non-invasive, accurate, and cost-effective screening strategies is of paramount importance. One particularly promising and innovative approach is the analysis of volatile organic compounds (VOCs), a field known as volatolomics. VOCs, which are metabolic by products released by the body, reflect underlying biochemical processes and offer a valuable, non-invasive source of diagnostic information. Recent advances have highlighted the potential of VOC profiling in PCa detection. A variety of biological systems have demonstrated remarkable sensitivity and specificity in recognizing disease-associated VOC signatures. Notably, trained dogs, selected invertebrates, and artificial sensing platforms have all shown the ability to identify PCa-related olfactory patterns. Among technological approaches, electronic noses (eNoses), which combine chemical sensor arrays with pattern recognition algorithms such as neural networks, represent a rapidly evolving diagnostic tool. Together, these biologically inspired and technology-driven strategies are reshaping the landscape of cancer diagnostics. They offer a compelling foundation for the development of rapid, non-invasive, and clinically translatable methods for PCa detection. This narrative review summarizes recent advances in using VOCs for PCa diagnosis and evaluates the reproducibility and clinical robustness of these approaches, focusing on challenges such as standardizing sampling, storage, and analysis, small cohort sizes, and the need for external validation and regulatory integration. Full article

Odor detection underpins food safety, environmental monitoring, medical diagnostics, and many more fields. Current artificial sensors developed for odor detection struggle with complex mixtures, while non-invasive recordings lack reliable single-trial fidelity. To develop a general system for odor detection, in this study we present preliminary work where we test two hypotheses: (i) that spectral features of local field potentials (LFPs) are sufficient for robust single-trial odor detection and (ii) that signals from the olfactory bulb alone are adequate. To test these hypotheses, we propose an ensemble of complementary one-dimensional convolutional networks (ResCNN and AttentionCNN) that decodes the presence of odor from multichannel olfactory bulb LFPs. Tested on 2349 trials from seven awake mice, our final ensemble model supports both hypotheses, achieving a mean accuracy of 86.2%, an F1-score of 85.3%, and an AUC of 0.942, substantially outperforming previous benchmarks. The t-SNE visualization confirms that our framework captures biologically significant signatures. These findings establish the feasibility of robust single-trial detection of odor presence from extracellular LFPs and demonstrate the potential of deep learning models to provide deeper understanding of olfactory representations. Full article

The exceptional olfactory capabilities of trained detection dogs demonstrate high potential for identifying infectious diseases. However, safe and standardized canine training requires specific chemical targets rather than infectious biological samples. This study presents an analytical proof-of-concept combining untargeted metabolomics and machine learning (ML) to decode the specific odor profile of SARS-CoV-2 infection. Using headspace solid-phase microextraction gas chromatography coupled with time-of-flight mass spectrometry (HS-SPME-GC/MS-ToF), axillary sweat samples from 76 individuals (SARS-CoV-2 positive and negative) were analyzed. Data preprocessing and dimensionality reduction were performed to feed a Partial Least Squares-Discriminant Analysis (PLS-DA) model. The optimized model achieved an overall accuracy of 79%, with a specificity of 89% and sensitivity of 70% in external validation, identifying a specific panel of Volatile Organic Compounds (VOCs) as discriminant biomarkers. The optimized model achieved robust classification performance, effectively distinguishing infected individuals from healthy controls based solely on their volatilome. Six VOCs were found to be consistently presented in COVID-19-positive individuals. These compounds were proposed as candidate odor signatures for constructing artificial training aids to standardize and accelerate the training of detection dogs. This study establishes a framework where machine learning-driven metabolomic profiling directly informs biological sensor training, offering a novel synergy between ML and biological intelligence in disease detection. This study establishes a scalable computational framework to translate biological samples into chemical data, providing the scientific basis for designing safe, synthetic K9 training aids for future infectious disease outbreaks without the biosafety risks associated with handling live pathogens. Full article

Confounding factors in olfactory aroma data, such as high humidity levels, substantially affect sensor outputs, masking subtle volatile organic compound (VOC) patterns and hindering generalizable machine learning models. Traditional representation learning methods often require large datasets to mitigate confounder-induced variance, a resource unavailable in specialized sensor applications with limited data. This study presents Confounder-Invariant Representation Learning (CIRL), a method designed to mitigate confounding influences in data-scarce settings by leveraging explicit confounder information, such as relative humidity. CIRL enhances learned representations by reducing confounder effects, improving data purity and model robustness. Applied to three breath aroma datasets—acetone, ketosis, and peppermint-oil breath, all affected by high humidity—CIRL was integrated with standard autoencoder models. Evaluated within the same framework, CIRL improved generalization performance by 10–15% in classification accuracy across all three datasets. These results demonstrate CIRL’s potential to advance reliable artificial olfaction for applications like breath-based diagnostics in challenging real-world conditions. Full article

Food quality assessment is a critical aspect of food production and safety, ensuring that products meet both regulatory and consumer standards. Traditional methods such as sensory evaluation, chromatography, and spectrophotometry are widely used but often suffer from limitations, including subjectivity, high costs, and time-consuming procedures. In recent years, the development of electronic nose (e-nose) and electronic tongue (e-tongue) technologies has provided rapid, objective, and reliable alternatives for food quality monitoring. These bio-inspired sensing systems mimic human olfactory and gustatory functions through sensor arrays and advanced data processing techniques, including artificial intelligence and pattern recognition algorithms. The e-nose is primarily used for detecting volatile organic compounds (VOCs) in food, making it effective for freshness evaluation, spoilage detection, aroma profiling, and adulteration identification. Meanwhile, the e-tongue analyzes liquid-phase components and is widely applied in taste assessment, beverage authentication, fermentation monitoring, and contaminant detection. Both technologies are extensively used in the quality control of dairy products, meat, seafood, fruits, beverages, and processed foods. Their ability to provide real-time, non-destructive, and high-throughput analysis makes them valuable tools in the food industry. This review explores the principles, advantages, and applications of e-nose and e-tongue systems in food quality assessment. Additionally, it discusses emerging trends, including IoT-based smart sensing, advances in nanotechnology, and AI-driven data analysis, which are expected to further enhance their efficiency and accuracy. With continuous innovation, these technologies are poised to revolutionize food safety and quality control, ensuring consumer satisfaction and compliance with global standards. Full article

Monitoring the quality of engine oil improves engine efficiency and reduces engine maintenance costs. Several methods have been proposed for this purpose; however, most of them take too long to test oil quality. This paper introduces a fast, simple, and accurate method to determine oil quality using an electronic nose and artificial intelligence. The TU5 engine and 10-40W “Behran Super Pishtaz” engine oil were used in the experiments. Tests were conducted at six different quality levels. Oil properties such as viscosity, density, flash point, and freezing point were measured at each level. Additionally, oil smell signals were recorded using an olfactory machine at these quality levels. The fraction method was employed to adjust the sensors’ responses. Five statistical features were extracted from each signal, and these features were used to train and test a support vector machine (SVM) for classifying oil quality using the five-fold cross-validation method. The results indicated a statistically significant change in viscosity and density with variations in oil quality. The density increased as the quality decreased. Viscosity, however, initially decreased and then increased at later stages. An analysis of the sensory outputs revealed that changes in oil quality also affected these outputs, with the most pronounced sensitivity observed in the MQ135 and MQ138 sensors. The final accuracies of the SVM in classifying oil quality were 68.22%, 85.86%, and 95.44% for linear, radial basis function (RBF), and polynomial kernels, respectively. The SVM sensitivities for oil qualities A, B, C, D, E, and F were 97.99%, 97.37%, 95.51%, 92.67%, 94.48%, and 94.59%, respectively. Full article

This study used an odor sensing system with a 16-channel electrochemical sensor array to measure beef odors, aiming to distinguish odors under different storage days and processing temperatures for quality monitoring. Six storage days ranged from purchase (D0) to eight days (D8), with three temperature conditions: no heat (RT), boiling (100 °C), and frying (180 °C). Gas chromatography–mass spectrometry (GC-MS) analysis showed that odorants in the beef varied under different conditions. Compounds like acetoin and 1-hexanol changed significantly with the storage days, while pyrazines and furans were more detectable at higher temperatures. The odor sensing system data were visualized using principal component analysis (PCA) and uniform manifold approximation and projection (UMAP). PCA and unsupervised UMAP clustered beef odors by storage days but struggled with the processing temperatures. Supervised UMAP accurately clustered different temperatures and dates. Machine learning analysis using six classifiers, including support vector machine, achieved 57% accuracy for PCA-reduced data, while unsupervised UMAP reached 49.1% accuracy. Supervised UMAP significantly enhanced the classification accuracy, achieving over 99.5% with the dimensionality reduced to three or above. Results suggest that the odor sensing system can sufficiently enhance non-destructive beef quality and safety monitoring. This research advances electronic nose applications and explores data downscaling techniques, providing valuable insights for future studies. Full article

Artificial olfaction, also known as an electronic nose, is a gas identification device that replicates the human olfactory organ. This system integrates sensor arrays to detect gases, data acquisition for signal processing, and data analysis for precise identification, enabling it to assess gases both qualitatively and quantitatively in complex settings. This article provides a brief overview of the research progress in electronic nose technology, which is divided into three main elements, focusing on gas-sensitive materials, electronic nose applications, and data analysis methods. Furthermore, the review explores both traditional MOS materials and the newer porous materials like MOFs for gas sensors, summarizing the applications of electronic noses across diverse fields including disease diagnosis, environmental monitoring, food safety, and agricultural production. Additionally, it covers electronic nose pattern recognition and signal drift suppression algorithms. Ultimately, the summary identifies challenges faced by current systems and offers innovative solutions for future advancements. Overall, this endeavor forges a solid foundation and establishes a conceptual framework for ongoing research in the field. Full article

Artificial scent screening systems, inspired by the mammalian olfactory system, hold promise for fruit ripeness detection, but their commercialization is limited by low sensitivity or pattern recognition inaccuracy. This study presents a portable fruit ripeness prediction system based on colorimetric sensing combinatorics and deep convolutional neural networks (DCNN) to accurately identify fruit ripeness. Using the gas chromatography–mass spectrometry (GC-MS) method, the study discerned the distinctive gases emitted by mango, peach, and banana across various ripening stages. The colorimetric sensing combinatorics utilized 25 dyes sensitive to fruit volatile gases, generating a distinct scent fingerprint through cross-reactivity to diverse concentrations and varieties of gases. The unique scent fingerprints can be identified using DCNN. After capturing colorimetric sensor image data, the densely connected convolutional network (DenseNet) was employed, achieving an impressive accuracy rate of 97.39% on the validation set and 82.20% on the test set in assessing fruit ripeness. This fruit ripeness prediction system, coupled with a DCNN, successfully addresses the issues of complex pattern recognition and low identification accuracy. Overall, this innovative tool exhibits high accuracy, non-destructiveness, practical applicability, convenience, and low cost, making it worth considering and developing for fruit ripeness detection. Full article

The technological advancements in sensory systems and robotics over the past decade have facilitated the innovation of centralized systems for optimizing resource utilization and monitoring efficiency in inspection applications. This paper presents a novel system designed for gas concentration sensing in environments by implementing a modular artificial nose (emulating the inhalation and exhalation process) equipped with a strategically designed air capture centralization system based on computational fluid dynamics analysis (CFD). The system incorporates three gas identification sensors distributed within the artificial nose, and their information is processed in real-time through embedded systems. The artificial nose is hardware–software integrated with a quadruped robot capable of traversing the environment to collect samples, maximizing coverage area through its mobility and locomotion capabilities. This integration provides a comprehensive perspective on gas distribution in a specific area, enabling the efficient detection of substances in the surrounding environment. The robotic platform employs a graphical interface for real-time gas concentration data map visualization. System integration is achieved using the Robot Operating System (ROS), leveraging its modularity and flexibility advantages. This innovative robotic approach offers a promising solution for enhanced environmental inspection and monitoring applications. Full article

The artificial olfactory image was proposed by Lundström et al. in 1991 as a new strategy for an electronic nose system which generated a two-dimensional mapping to be interpreted as a fingerprint of the detected gas species. The potential distribution generated by the catalytic metals integrated into a semiconductor field-effect structure was read as a photocurrent signal generated by scanning light pulses. The impact of the proposed technology spread beyond gas sensing, inspiring the development of various imaging modalities based on the light addressing of field-effect structures to obtain spatial maps of pH distribution, ions, molecules, and impedance, and these modalities have been applied in both biological and non-biological systems. These light-addressing technologies have been further developed to realize the position control of a faradaic current on the electrode surface for localized electrochemical reactions and amperometric measurements, as well as the actuation of liquids in microfluidic devices. Full article

With the development of the field of e-nose research, the potential for application is increasing in various fields, such as leak measurement, environmental monitoring, and virtual reality. In this study, we characterize electronic nose data as structured data and investigate and analyze the learning efficiency and accuracy of deep learning models that use unstructured data. For this purpose, we use the MOX sensor dataset collected in a wind tunnel, which is one of the most popular public datasets in electronic nose research. Additionally, a gas detection platform was constructed using commercial sensors and embedded boards, and experimental data were collected in a hood environment such as used in chemical experiments. We investigated the accuracy and learning efficiency of deep learning models such as deep learning networks, convolutional neural networks, and long short-term memory, as well as boosting models, which are robust models on structured data, using both public and specially collected datasets. The results showed that the boosting models had a faster and more robust performance than deep learning series models. Full article

In order to improve the precision of gas detection and develop valid search strategies, the improved quantitative identification algorithm in odor source searching was researched based on the gas sensor array. The gas sensor array was devised corresponding to the artificial olfactory system, and the one-to-one response mode to the measured gas was set up with its inherent cross-sensitive properties. The quantitative identification algorithms were researched, and the improved Back Propagation algorithm was proposed combining cuckoo algorithm and simulated annealing algorithm. The test results prove that using the improved algorithm to obtain the optimal solution −1 at the 424th iteration of the Schaffer function with 0% error. The gas detection system designed with MATLAB was used to obtain the detected gas concentration information, then the concentration change curve may be achieved. The results show that the gas sensor array can detect the concentration of alcohol and methane in the corresponding concentration detection range and show a good detection performance. The test plan was designed, and the test platform in a simulated environment in the laboratory was found. The concentration prediction of experimental data selected randomly was made by the neural network, and the evaluation indices were defined. The search algorithm and strategy were developed, and the experimental verification was carried out. It is testified that the zigzag searching stage with an initial angle of 45° is with fewer steps, faster searching speed, and a more exact position to discover the highest concentration point. Full article

Biomedical receptors such as cutaneous receptors or intelligent cells with tactile, auditory, gustatory, and olfactory sensations function in the five senses of the human body. Investigations focusing on the configuration of such receptors are useful in the fields of robotics and sensors in the food industry, among others, which involve artificial organs or sensory machines. In the present study, we aimed to produce the receptors for four senses (excepting vision) by morphologically mimicking virtual human ones. The mimicked receptors were categorized into eight types of configured structure. Our proposed magnetic-responsive hybrid fluid (HF) in elastic and soft rubber and proposed electrolytic polymerization technique gave the solidified HF rubber electric characteristics of piezoelectricity and piezo-capacity, among others. On the basis of these electric characteristics, the mimicked receptors were configured in various types of electric circuits. Through experimental estimation of mechanical force, vibration, thermal, auditory, gustatory, and olfactory responses of each receptor, the optimum function of each was specified by comparison with the actual sensations of the receptors. The effect of hairs fabricated in the receptors was also clarified to viably reproduce the distinctive functions of these sensations. Full article

In the past 20 years, the development of an artificial olfactory system has made great progress and improvements. In recent years, as a new type of sensor, nanoelectronic smelling has been widely used in the food and drug industry because of its advantages of accurate sensitivity and good selectivity. This paper reviews the latest applications and progress of nanoelectronic smelling in animal-, plant-, and microbial-based foods. This includes an analysis of the status of nanoelectronic smelling in animal-based foods, an analysis of its harmful composition in plant-based foods, and an analysis of the microorganism quantity in microbial-based foods. We also conduct a flavor component analysis and an assessment of the advantages of nanoelectronic smelling. On this basis, the principles and structures of nanoelectronic smelling are also analyzed. Finally, the limitations and challenges of nanoelectronic smelling are summarized, and the future development of nanoelectronic smelling is proposed. Full article