Search Results (173)

It is of great significance for accident prevention to explore the causes and evolution laws of ship collisions at sea. The paper aims to constructs a systematic MMEM-FTA integrated analysis framework and applies the framework to analyze the causes of ship collisions in Taizhou coastal waters. Ship collision cases in Taizhou coastal waters from 2017 to 2025 are collected, and a statistical analysis is conducted on the characteristics of collision accidents. Under the MMEM frame, 16 accident influencing factors are identified from four aspects: personnel negligence, ship failure, management failure and environmental degradation. Based on FTA, a fault tree diagram of ship collision accidents in Taizhou coastal waters is constructed. Results of both quantitative and quantitative analysis show that the structural importance of ship failure, management failure and complex environment is the largest and an event with higher probabilistic and critical importance is “Unseaworthiness.” These mentioned events are main reasons for ship collision accidents. Suggestions on risk control options (RCOs) for accident prevention are put forward under the MMEM frame. The proposed MMEM-FTA integrated analysis framework is feasible for accident causation analysis. This research can provide theoretical and practical supports for identifying causes of ship collisions, for elucidating the evolution mechanism of accidents and for taking targeted measures to prevent accidental risks. Full article

Progressive collapse has become a critical concern in resilient structural design due to accidental impacts, abnormal loading scenarios, and sudden localized damage events that may lead to the sudden loss of structural elements under extreme or unforeseen actions. In this context, UFC 4-023-03 provides design approaches for improving collapse resistance, including the Alternate Path Method, Enhanced Local Resistance Method, and Tie Forces Method. This study focuses on the Tie Forces Method, which is based on mechanical interconnection but remains relatively underexamined in the literature. A six-story reinforced concrete office building was evaluated to determine the required tie reinforcement area for progressive collapse resistance according to UFC 4-023-03. Ten national building codes were considered, with office live loads ranging from approximately 2.0 to 4.8 kN/m². In this study, the selected national codes are not compared in terms of their complete progressive collapse provisions. Instead, UFC 4-023-03 is adopted as the main Tie Forces Method calculation framework, while national-code-based live load values and reinforcement properties are used as input parameters. Peripheral, longitudinal, transverse, and vertical ties were comparatively assessed. The largest percentage reduction was observed for the peripheral transverse tie reinforcement at the first floor, where the Eurocode-based input set produced a required tie reinforcement area approximately 21.7% lower than that obtained from the Russian input set. In contrast, Canadian provisions govern the highest demand at the ground floor, while South Korean provisions produce the highest demand at upper floors. Overall, the findings highlight the influence of national live load provisions and reinforcement properties on tie force requirements. Full article

Background: Acute drug poisoning is one of the leading causes of admission to pediatric emergency departments and represents a significant public health concern because of its potential severity and associated morbidity and mortality. This study aimed to describe the clinical, epidemiological, and severity characteristics of pediatric patients with acute drug poisoning treated at a tertiary care hospital in western Mexico. Methods: A retrospective, observational, descriptive study was conducted in the pediatric emergency department of Nuevo Hospital Civil de Guadalajara “Dr. Juan I. Menchaca” from January 2016 to December 2024. Results: The mean age of the patients was 77.1 months, with a predominance of females (61.9%). Most poisoning events (97.1%) occurred in the home. Accidental poisoning was the most frequent mechanism (54.5%), followed by suicide attempts (24.4%) and drug overdoses (17.6%). Regarding medical care, 50% of patients arrived at the emergency department within the first four hours after exposure, and 55.1% had a hospital stay of less than 12 h. The most involved drug groups were anxiolytics, mainly benzodiazepines (21.6%), followed by polypharmacy (17.6%) and antiemetic use (13.6%). The most frequent toxidrome was hypnotic–sedative syndrome (42.6% of cases). Multivariate analysis showed that exposure to anticonvulsants was significantly associated with a longer hospital stay (odds ratio [OR] = 7.31, p = 0.003). Most cases were classified as mild according to the Poisoning Severity Score, and no deaths were reported. Conclusions: Although pediatric drug poisoning generally has a favorable prognosis, it remains a significant public health issue. These findings highlight the need for targeted preventive strategies, including caregiver education, safe medication storage at home, and increased awareness and training programs for both families and healthcare professionals. Full article

Aconitum poisoning is a major public health concern in East Asia, and remains difficult to diagnose when the causative toxins are not covered by routine targeted assays. In a poisoning incident that occurred in 2018, 15 individuals were affected, including five fatalities, after accidentally consuming a medicinal tincture during a shared meal. The comprehensive alkaloid profile of the tincture implicated in the poisoning was achieved through the integration of targeted analysis, molecular networking, and untargeted screening based on ultra-high performance liquid chromatography coupled to time-of-flight mass spectrometry, aiming to clarify the causative agents. Targeted quantitative analysis detected nine alkaloids derived from Aconitum plants, confirming the presence of Aconitum ingredients in the medicinal tincture. However, these alkaloids were either present at low concentrations or exhibited low toxicity, and thus were not the principal causative agents of this poisoning incident. Molecular networking revealed additional hidden diester-diterpenoid alkaloids (DDAs) and monoester-diterpenoid alkaloids (MDAs) that were undetected by targeted analysis. Untargeted screening identified 58 Aconitum alkaloids, including 15 DDAs, 17 MDAs, 17 amino-diterpenoid alkaloids (ADAs), 2 C20-diterpenoid alkaloids, and seven unclassified alkaloids. The three most abundant alkaloids were structurally identified as pseudoaconitine, 8-deacetylpseudoaconitine, and 3′-methoxyacoforestinine, and were identified as the main causative agents of this poisoning. To our knowledge, this is the first detection of these alkaloids in Aconitum poisoning in China. These findings demonstrate that integrated targeted and untargeted toxicological analysis can identify undocumented toxins in poisoning events of unknown origin and clarify the chemical etiology of unusual Aconitum poisoning. Full article

Fatal free falls (FFF) represent a distinct form of blunt force trauma and pose a significant challenge in forensic investigations, particularly in estimating fall height and differentiating between accidental and suicidal events. Postmortem computed tomography (PMCT) enables detailed assessment of skeletal injuries, including quantitative evaluation of skull fracture patterns. Total Cranial Fracture Length (TCFL), derived from three-dimensional CT skull fracture scoring (3D-CT-SF), has been proposed as an objective indicator of impact severity; however, available evidence remains limited. This study aimed to assess the relationship between TCFL and fall height in fatal free falls and to evaluate the influence of selected anthropometric and biomechanical variables on cranial fracture severity. A retrospective analysis of 76 fatal free-fall cases examined between 2016 and 2024 was conducted using PMCT and autopsy data. TCFL was measured on three-dimensional volume-rendered CT reconstructions of calvarial fractures. Statistical analyses were performed for the entire cohort and separately for accidental and suicidal falls. No significant correlation between TCFL and fall height was observed in the overall cohort or among suicide cases. In contrast, a significant negative correlation between TCFL and fall height category was identified in accidental falls. TCFL showed significant positive correlations with body mass, body mass index (BMI), and kinetic energy, particularly in the suicide subgroup. TCFL is a promising objective parameter for assessing the severity of cranial injury in fatal free-fall cases. While its utility in estimating fall height appears limited in suicidal falls, TCFL may support forensic interpretation of fall dynamics and contribute to distinguishing the manner of death, especially in accidental cases. Further studies in larger, more diverse populations are warranted. Full article

Dioxins are highly persistent organic pollutants that exist in soil. Their hydrophobic and lipophilic characteristics facilitate long-term stability, posing high risks to the ecosystem and human health. They can be released by different sources, such as the incineration of waste materials, industrial activities, the production of pesticides, and natural or accidental events like forest fires. Dioxins accumulate in food chains and persist in the environment because dioxins are less volatile as well as chemically stable and can strongly bind to organic matter. The accumulation and persistence of dioxins in aquatic and terrestrial systems make them a significant threat to the environment, even at very low concentrations. This review explains the key sources of dioxin-contaminated soil, including industrial emissions and atmospheric deposition, and assesses the associated risks. The transport, places of contamination, and overall status of dioxins are also highlighted in this study. The review also examines the mechanisms of dioxin toxicity, focusing on their interference with hormonal functions and gene expression, as mediated through the aryl hydrocarbon receptor (AhR). This AhR activation leads to gene responses and causes immunotoxicity, endocrine disruption, and oxidative stress. Furthermore, various remediation strategies like biological, physical, and chemical remediation are discussed here as effective approaches for reducing ecological and health risks and promoting soil sustainability. Full article

Urban water distribution systems (WDSs) face increasing threats from accidental or intentional contaminant intrusion events. While contamination warning systems using water quality sensors enable early detection and rapid response to contamination events, traditional sensor placement approaches often rely on a single or limited performance metric, overlooking the multidimensional nature of system resilience. This study presents a multidimensional resilience-based framework for the optimal placement of water quality sensors in urban WDSs, integrating hydraulic and water quality simulations using the EPANET-MATLAB toolkit with a genetic algorithm (GA) optimization process. For Anytown Water Distribution Network, four distinct functionalities were formulated to capture different aspects of system performance during contamination events, and an integrated-multidimensional resilience metric was proposed as a collective measure. Results demonstrated that the optimal sensor configurations varied significantly depending on the selected functionality. However, the integrated multidimensional resilience-based approach yielded more balanced and effective sensor placements, simultaneously enhancing resilience levels for all individual functionalities. Furthermore, the findings indicated that adding more sensors beyond a certain number offers marginal improvements in system resilience, suggesting that sensor deployment should be guided by monitoring objectives (e.g., resilience) rather than simply increasing sensor numbers. The findings and discussion suggest practical insights for utilities to enhance water supply services with safe quality and system security against contamination threats in urban WDSs. Full article

This study examines the chronic continuity and multi-layered structure of poisoning cases observed in the Ottoman Empire between the 1845 and 1912. The primary aim is to reveal how the central administration perceived these events, which seriously threatened food safety and public health, and the administrative, medical, and legal defence mechanisms developed in response. The scope of the research encompasses Ottoman Archive documents ranging from accidental poisonings to consumption of spoiled food, use of untinned vessel, and large-scale military poisonings. Conducted using qualitative methods, the study involved transcribing, classifying, and interpreting archival data. These records confirm that the administrators of the period considered poisoning to be a significant and challenging threat. Consequently, this study evaluates the information in the archival documents at the intersection of forensic epidemiology and political toxicology, substantiating with data the risk management capacity of the central administration of the period and its institutional adaptation to crises. By analysing poisoning cases through the lens of food safety and public health policies, the research offers a new academic contribution to Ottoman history, medical history, public health history, and food safety literature. Full article

The skin, the largest organ in the human body, serves as a crucial barrier against external stimuli. With the acceleration of social industrialization and the worsening of global climate change, the risk of physical, chemical and biological damage to the skin has significantly increased. Among these, surgical wounds, accidental injuries, diabetic wounds, and ultraviolet (UV)-radiation-induced photoaging are particularly common. Cutaneous wound healing is a complex and dynamic process that requires precise coordination of numerous molecular events to effectively repair damaged skin. Skin photoaging, a phenomenon of premature aging caused by long-term UV exposure, is characterized by pigmentary abnormalities, telangiectasia, epidermal roughness, wrinkle formation, and precancerous lesions, all of which seriously affect skin health and appearance. Extracellular vesicles (EVs), a class of nano-sized vesicles secreted by various cells, play important regulatory roles in tissue regeneration. Although cell-culture-medium-derived EVs (C-EVs) have been proven to effectively promote skin wound healing and photodamage repair, their origin from a single cell type and challenges in large-scale production severely limit their broad application. In contrast, EVs derived from natural biological resources, including tissue-derived EVs (Ti-EVs) and plant-derived EVs (PDEVs), have emerged as novel therapeutic strategies for skin wounds and photoaging. These EVs better reflect the physiological microenvironment and demonstrate considerably higher production efficiencies. Ti-EVs, obtained from mammalian tissues composed of multiple cell types and extracellular matrix, contain more abundant regulatory factors, thus exhibiting superior bioactivity compared with C-EVs. PDEVs have also garnered significant attention due to their favorable stability, low immunogenicity, unique natural antioxidant components, and feasibility of large-scale extraction. This review will systematically elaborate on the characteristics and isolation methods of both Ti-EVs and PDEVs, as well as their therapeutic roles and underlying mechanism in wound healing and skin photoaging. Full article

Airborne iodine-131 plays a pivotal role in both nuclear medicine and nuclear safety due to its radiotoxicity, volatility, and affinity for the thyroid gland. Although the total exhaled activity after medical I-131 therapy is minimal, over 95% of this activity appears in volatile organic forms, which evade standard filtration and reflect metabolic pathways of iodine turnover. Our experimental work in patients and mice confirms the metabolic origin of these species, modulated by thyroidal function. In nuclear reactor environments, both under routine operation and during accidents, organic iodides such as [¹³¹I]CH₃I have also been identified as major airborne components, often termed “penetrating iodine” due to their low adsorption to conventional filters. This review compares the molecular speciation, environmental persistence, and dosimetric impact of airborne I-131 across clinical, technical, and accidental release scenarios. While routine reactor emissions yield negligible doses (<0.1 µSv/year), severe nuclear incidents like Chernobyl and Fukushima have resulted in significant thyroid exposures. Doses from these events ranged from tens of millisieverts to several Sieverts, particularly in children. We argue that a deeper understanding of chemical forms is essential for effective risk assessment, filtration technology, and emergency preparedness. Iodine-131 exemplifies the dual nature of radioactive substances: in nuclear medicine its radiotoxicity is therapeutically harnessed, whereas in industrial or reactor contexts it represents an unwanted hazard. The same physicochemical properties that enable therapeutic efficacy also determine, in the event of uncontrolled release, the range, persistence, and the potential for unwanted radiotoxic exposure in the general population. In nuclear medicine, exhaled activity after radioiodine therapy is minute but largely organically bound, reflecting enzymatic and metabolic methylation processes. During normal reactor operation, airborne iodine levels are negligible and dominated by inorganic vapors efficiently captured by filtration systems. In contrast, major accidents released large fractions of volatile iodine, primarily as elemental [¹³¹I]I₂ and organically bound iodine species like [¹³¹I]CH₃I. The chemical nature of these compounds defined their atmospheric lifetime, transport distance, and deposition pattern, thereby governing the thyroid dose to exposed populations. Chemical speciation is the key determinant across all scenarios. Exhaled iodine in medicine is predominantly organic; routine reactor releases are negligible; severe accidents predominantly release elemental and organic iodine that drive environmental transport and exposure. Integrating these domains shows how chemical speciation governs volatility, mobility, and bioavailability. The novelty of this review lies not in introducing new iodine chemistry, but in the systematic comparative synthesis of airborne radioiodine speciation across medical therapy, routine nuclear operation, and severe accident scenarios, identifying chemical form as the unifying determinant of volatility, environmental transport, and dose. Full article

A better understanding of cultivation of microorganisms in mixed culture is needed to identify the relationships between different bacterial strains. Lactobacillus acidophilus (ATCC 4796) Gram-positive bacteria and Escherichia coli (K12-MG1655) Gram-negative bacteria are two microorganisms that can interact accidentally in the dairy food chain process or in different human pathologies. This work focused on how bacterial populations evolve in batch culture, depending on the nature of the carbon source, by monitoring cell viability using flow cytometry and substrate concentration. The experiments monitored the time evolution of bacterial populations grown on two different cultivation media (single source of carbon—SSCM and de Man, Rogosa and Sharpe—MRS broth media) which stimulated different proliferation conditions. Experimental data were used to calibrate a segregated mathematical model (accounting for two bacterial strains—biological clusters—with their individual birth time, an event that creates a new timeline cluster to which daughters belong) that highlights in silico the various interactions that can occur between two bacterial species. Full article

Vibrations of unknown origin can cause fear and confusion when their sources are unrecognized. In modern construction environments, such vibrations may result not only from earthquakes but also from accidental impacts during industrial operations. However, due to the absence of established safety standards, evaluating and compensating for the effects of short-duration, high-intensity vibrations has remained difficult. This study investigates the characteristics of ground motions induced by accidental impact loads through finite element-based numerical simulations. The analyses identify key factors that control vibration propagation under various subsurface conditions. The results show that an impact load produces a single impulsive motion dominated by a vertical component, which decays exponentially with time. The amplitude of vibration increases with drop height and girder mass, confirming the relationship between potential energy and vibration intensity. The attenuation of peak particle velocity (PPV) follows a logarithmic pattern with distance, and the variation in attenuation depends on soil thickness and the presence of a weathered-rock layer. These results demonstrate that both the magnitude of impact and the ground composition control the amplitude, frequency content, and duration of impact-induced vibrations, providing a basis for assessing unmonitored accidental events. Full article

Approximately 27.6% of Italian beaches are currently affected by erosion, despite the widespread implementation of coastal defence structures. Around 10,500 installations—mainly groins and detached breakwaters—occupy nearly 24.6% of the national shoreline. Although primarily designed to protect tourist beaches, these hard-engineered structures often degrade coastal landscapes, alter nearshore circulation, and pose risks to swimmers. Nevertheless, beaches remain a fundamental asset for the “3S” (Sun, Sea, Sand) tourism sector, which contributes approximately 2.2% to Italy’s GDP, accounting for over 175 million tourists’ overnight stays in 2024, frequently concentrated near protected coastal zones. In this study, drowning incidents along the Italian coastline were analyzed using press reports complemented by official statistics. Between 2016 and 2021, an average of 145 fatalities occurred per bathing season. Sudden drownings following medical emergencies accounted for 41% of cases, non-swimmers for 18%, accidental falls into the water for 3%, and water sports activities for an additional 3%. Rip currents on natural beaches were responsible for 22% of drownings, whereas those generated by coastal defence structures accounted for 12%. A further 12% of non-swimmer fatalities are suspected to have resulted from falls into depressions or channels formed in proximity to these structures. Evidence from previous studies and seabed morphology analyses indicates that coastal defence structures can generate rip currents through two main mechanisms: (1) hydraulic pressure exerted against groins, which drives offshore flow, and (2) water outflow between pairs of breakwaters resulting from wave setup behind them. Both processes, though often less intense, are also observed near submerged structures. The erosional channels formed by these currents may persist well beyond storm events, maintaining dangerous conditions for bathers. As Italy continues to rely predominantly on hard coastal protection measures, improving the understanding of drowning dynamics associated with these structures is crucial. This should be accompanied by regulatory updates requiring designers and coastal managers to systematically assess related hazards and to propose effective mitigation and safety strategies. Full article

Although the accidental or intentional explosions produced in industrial facilities or in urban areas are events with low probability, they have a high destructive potential and potential for human injuries and/or fatalities. One of the types of such events is given by detonation of improvised explosive devices (IEDs)—dirty bombs for terrorist purposes—which may produce a high number of metallic fragments. Studying mass and spatial distributions of these fragments is useful for evaluating their lethality and destructive potential and may help to implement adequate protective measures. This work brings a closer insight into the fragment dispersion around the detonation of a steel-enclosed C4 charge with cylindrical symmetry. In this respect a specific approach involving both detonation experiments and numerical simulations performed by home-made and commercial software packages for investigation of the fragmentation process and accompanying angular scattering of the fragments was proposed. Special algorithms, which allow the estimation of the spatial distributions of fragments from the numerical analysis of perforations made by the metallic fragments generated by such IEDs on surrounding material walls, are developed. Further, numerical simulations of a similar IED device provided output parameters related to the statistical distributions of mass, kinetic energy and position of the fragments. Experimental fragmentation generated a recovered mass distribution (94 fragments of 67.5 g) that was compared with that extracted from simulation, revealing a reasonable agreement on the 0.3–1 g range. In the case of simulations, 300 fragments from a total number of 374 showed a mass ranging from 0.004 to 0.3 g. The simulations showed that the middle part of the steel case generated fragments of kinetic energy over 4 kJ and its ends generated fragments of kinetic energy under 1 kJ. Experimental fragment scattering distributions were investigated with specific home-made numerical algorithms, which, based on a set of images, analysed the correlations between spatial coordinates of perforations made by fragments on surrounding special panels and provided histograms that are discussed in relation with the fragment-induced lethality degree. Full article

Liquefied petroleum gas (LPG), composed mainly of propane and butane, is widely used as an energy source in residential, commercial, and industrial sectors; however, its high flammability poses a critical risk in the event of accidental leaks. In Peru, where LPG constitutes the main domestic energy source, leakage emergencies affect thousands of households each year. This pattern is replicated in developing countries with limited energy infrastructure. Early quantitative detection of propane, the predominant component of Peruvian LPG (~60%), is essential to prevent explosions, poisoning, and greenhouse gas emissions that hinder climate change mitigation strategies. This study presents PropNet-R, a convolutional neural network (CNN) designed to estimate propane concentrations (ppm) from thermal images. A dataset of 3574 thermal images synchronized with concentration measurements was collected under controlled conditions. PropNet-R, composed of four progressive convolutional blocks, was compared with SqueezeNet, VGG19, and ResNet50, all fine-tuned for regression tasks. On the test set, PropNet-R achieved MSE = 0.240, R² = 0.614, MAE = 0.333, and Pearson’s r = 0.786, outperforming SqueezeNet (MSE = 0.374, R² = 0.397), VGG19 (MSE = 0.447, R² = 0.280), and ResNet50 (MSE = 0.474, R² = 0.236). These findings provide empirical evidence that task-specific CNN architectures outperform generic transfer learning models in thermal image-based regression. By enabling continuous and quantitative monitoring of gas leaks, PropNet-R enhances safety in industrial and urban environments, complementing conventional chemical sensors. The proposed model contributes to the development of sustainable infrastructure by reducing gas-related risks, promoting energy security, and strengthening resilient, safe, and environmentally responsible urban systems. Full article