Toxic and Protective Compounds from Poisonous and Medicinal Plants: Toxicological, Mechanistic, Analytical, and Therapeutic Aspects

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Plant Toxins".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 807

Editors


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Guest Editor
Department of Functional Sciences, Faculty of Veterinary Medicine, Pharmacology and Toxicology, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, Sart Tilman, 4000 Liege, Belgium
Interests: poisonous plants for herbivorous; atypical myopathy; applied veterinary medicine; mitochondrial function in health and disease; comparative veterinary medicine; sport horses
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Guest Editor
Department of Pharmacy, Center of Interdisciplinary Research on Medicines (CIRM), University of Liege, 4000 Liege, Belgium
Interests: pharmacognosy; phytochemistry; phytotherapy; ethnopharmacology; plant metabolites analysis

Special Issue Information

Dear Colleagues,

Plants synthesise a remarkable diversity of natural metabolites capable of exerting toxic, protective, or therapeutic effects, often in a dose‑dependent and context‑dependent manner. This Special Issue aims to gather original research articles and reviews that advance our understanding of plant-derived phytotoxins and protective or therapeutic compounds from both poisonous and medicinal species.

We particularly welcome studies addressing the following:

  • Identification, structural characterisation, and analytical determination of plant toxins and bioactive protective molecules.
  • Toxicological evaluation (in vitro, in vivo, in silico) of phytotoxins and natural therapeutic compounds.
  • Mechanistic insights at molecular, cellular, biochemical, and physiological levels.
  • Dose–response relationships, metabolic activation, detoxification pathways, and organ-specific toxicity.
  • Protective and therapeutic effects, including cytoprotective, anti-inflammatory, antioxidant, or chemopreventive activities.
  • Profiling of toxic or protective compounds in medicinal plants, poisonous plants, herbal medicines, foods, and environmental matrices.
  • Implications for pharmacognosy, phytomedicine, herbal safety, and risk assessment. 

Review articles are expected to be submitted by authors with demonstrated expertise in the relevant field, as evidenced by prior peer-reviewed publications on the topic addressed. Articles and reviews related to veterinary medicine are particularly welcome. 

By integrating toxicology, pharmacognosy, analytical chemistry, and mechanistic biology, this Special Issue aims to advance a comprehensive understanding on the balance between plant toxicity and plant‑derived protection

Another goal of this Special Issue is to provide a comprehensive platform for advancing knowledge within the areas of toxicology, mechanism‑driven research, phytochemistry, and analytical sciences.

Dr. Dominique-Marie Votion
Dr. Olivia Jansen
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytotoxins
  • poisonous plants
  • bioactive natural compounds
  • medicinal plants
  • phytotherapy
  • phytochem-ical analysis
  • pharmacognosy
  • pathophysiology

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Published Papers (1 paper)

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Research

20 pages, 865 KB  
Article
Unveiling Hidden Aconitum Alkaloids in a Poisoning-Implicated Tincture by Untargeted Screening and Molecular Networking
by Qian He, Micong Jin, Jing Zhou, Hongshun Zhang and Chengye Sun
Toxins 2026, 18(6), 255; https://doi.org/10.3390/toxins18060255 - 5 Jun 2026
Viewed by 418
Abstract
Aconitum poisoning is a major public health concern in East Asia, and remains difficult to diagnose when the causative toxins are not covered by routine targeted assays. In a poisoning incident that occurred in 2018, 15 individuals were affected, including five fatalities, after [...] Read more.
Aconitum poisoning is a major public health concern in East Asia, and remains difficult to diagnose when the causative toxins are not covered by routine targeted assays. In a poisoning incident that occurred in 2018, 15 individuals were affected, including five fatalities, after accidentally consuming a medicinal tincture during a shared meal. The comprehensive alkaloid profile of the tincture implicated in the poisoning was achieved through the integration of targeted analysis, molecular networking, and untargeted screening based on ultra-high performance liquid chromatography coupled to time-of-flight mass spectrometry, aiming to clarify the causative agents. Targeted quantitative analysis detected nine alkaloids derived from Aconitum plants, confirming the presence of Aconitum ingredients in the medicinal tincture. However, these alkaloids were either present at low concentrations or exhibited low toxicity, and thus were not the principal causative agents of this poisoning incident. Molecular networking revealed additional hidden diester-diterpenoid alkaloids (DDAs) and monoester-diterpenoid alkaloids (MDAs) that were undetected by targeted analysis. Untargeted screening identified 58 Aconitum alkaloids, including 15 DDAs, 17 MDAs, 17 amino-diterpenoid alkaloids (ADAs), 2 C20-diterpenoid alkaloids, and seven unclassified alkaloids. The three most abundant alkaloids were structurally identified as pseudoaconitine, 8-deacetylpseudoaconitine, and 3′-methoxyacoforestinine, and were identified as the main causative agents of this poisoning. To our knowledge, this is the first detection of these alkaloids in Aconitum poisoning in China. These findings demonstrate that integrated targeted and untargeted toxicological analysis can identify undocumented toxins in poisoning events of unknown origin and clarify the chemical etiology of unusual Aconitum poisoning. Full article
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